Our Mission

We envision a world in which there is free and unrestricted access to information on malaria, independent of geographical locality or socio-economic status. No matter who you are, where you are, or what you do, access to information is the key to knowledge.
 
Knowledge empowers. Empowered people prevent and control malaria better.

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Last week at MalariaWorld... Our silence, post-doc fellowships, and blogs!

Yesterday I was thinking how I should inform you all about our silence over the last three weeks. There were no weekly 'Last week at MalariaWorld...' items after all. Well, let me be open about this. Our daughter has been seriously ill in hospital with complications following a ruptured appendix. This has taken most of our time and energy. Fortunately she is on her way up again, and so will our involvement with MalariaWorld.
 
This week a call for post-doc fellowships from Colorado State University to work on endectocides for malaria parasite transmission control. An exciting project with field work in Senegal, so if this interests you, click here.
 
Also this week a Guest Editorial from Dr. Lotte Van Dijk about counterfeit drugs and the awful reality of this trade. Read her story here.
 
And finally a very interesting and thought-provoking contribution from Dr. Ricardo Ataide about 'us': MalariaWorld. For instance, why is nobody responding to Giana Gomes' call for help? He also wonders why there isn't more debate and interaction on the platform and has some interesting explanations. Read his words here.
 
Enjoy this week's MalariaWorld - the MW team.

Open Access | A Vectorial Capacity Product to Monitor Changing Malaria Transmission Potential in Epidemic Regions of Africa

Author(s): 
Pietro Ceccato,Christelle Vancutsem, Robert Klaver, James Rowland, and Stephen J. Connor
Reference: 
Journal of Tropical Medicine, Volume 2012 (2012)
Contact email: 
pceccato@iri.columbia.edu

MalariaWorldIn this study, the vectorial capacity model (VCAP) was expanded to include the influence of rainfall and temperature variables on malaria transmission potential.

Assembly of the Eukaryotic PLP-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme

Author(s): 
Gabriela Guédez, Katharina Hipp, Volker Windeisen, Bianca Derrer, Martin Gengenbacher, Bettina Böttcher, Irmgard Sinning, Barbara Kappes, Ivo Tews
Reference: 
Structure, Volume 20, Issue 1, 11 January 2012, Pages 172–184
Contact email: 
ivo_tews@yahoo.com

MalariaWorldThe EM analysis shown here reveals a random association pattern of up to 12 Pdx2 glutaminase subunits to the dodecameric Pdx1 core complex.

Open Access | A Plasma Survey Using 38 PfEMP1 Domains Reveals Frequent Recognition of the Plasmodium falciparum Antigen VAR2CSA among Young Tanzanian Children

Author(s): 
Andrew V. Oleinikov, Valentina V. Voronkova, Isaac Tyler Frye, Emily Amos, Robert Morrison, Michal Fried, Patrick E. Duffy
Reference: 
PLoS ONE 7(1): e31011

MalariaWorldPfEMP1 proteins comprise a family of variant antigens that appear on the surface of P. falciparum-infected erythrocytes and bind to multiple host receptors.

Open Access | Inhibitory Potential of Prodomain of Plasmodium falciparum Protease Serine Repeat Antigen 5 for Asexual Blood Stages of Parasite

Author(s): 
Asrar Alam, Virander S. Chauhan
Reference: 
PLoS ONE 7(1): e30452
Contact email: 
virander@icgeb.res.in

MalariaWorldPlasmodium falciparum serine repeat antigen 5 (SERA5) is a target for both drug and vaccine intervention against malaria.

Open Access | Peripheral hemophagocytosis in malaria infection

Author(s): 
Emilie Klein and Emily Ronez
Reference: 
Blood January 26, 2012 vol. 119 no. 4 910
Contact email: 
emily.ronez@lrp.aphp.fr

MalariaWorldA 46-year-old man with stable HIV and hepatitis C virus chronic infection was seen for unexplained fever, headache, and vomiting after a trip to Cameroon.

Open Access | Comparing changes in haematologic parameters occurring in patients included in randomized controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa

Author(s): 
Zwang J, Ndiaye J, Djimde A, Dorsey G, Martensson A, Karema C, Olliaro P
Reference: 
Malaria Journal 2012, 11:25 (25 January 2012)
Contact email: 
zwang@free.fr

MalariaWorldThe effects of AS&AQ on haematologic parameters were not different from those of other anti-malarial treatments used in sub-Saharan Africa.

Postdoctoral Fellows: Malaria research

Deadline for applications: February 13, 2012 (position open until filled)
Organisation: Colorado State University
Location: USA
4.333335
Average: 4.3 (3 votes)

Open Access | Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children

Tags:
Author(s): 
Diana Quelhas, Laura Puyol, Carlota Dobano, et al.
Reference: 
BMC Immunology 2012, 13:5
Contact email: 
dianaquelhas@yahoo.co.uk

MalariaWorldMultiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months.

Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae

Author(s): 
Maureen J. Gorman, Lucinda I. Sullivan, Thi D.T. Nguyen, Huaien Dai, Yasuyuki Arakane, Neal T. Dittmer, Lateef U. Syed, Jun Li, Duy H. Hua, Michael R. Kanost
Reference: 
Insect Biochemistry and Molecular Biology, Volume 42, Issue 3, March 2012, Pages 193-202
Contact email: 
mgorman@ksu.edu

MalariaWorldThese results support the hypothesis that dopamine, NADA and NBAD are endogenous substrates for both isoforms of laccase-2. Catalytic efficiencies associated with dopa oxidation were low, ranging from 8 to 30 min−1 mM−1; in comparison, insect tyrosinase oxidized dopa with a catalytic efficiency of 201 min−1 mM−1.

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