Our Mission

We envision a world in which there is free and unrestricted access to information on malaria, independent of geographical locality or socio-economic status. No matter who you are, where you are, or what you do, access to information is the key to knowledge.
 
Knowledge empowers. Empowered people prevent and control malaria better.

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Last week at MalariaWorld...Another postdoc position, more on fake drugs...and more.

This week we're listing another exciting position, this time with the Pasteur Institute in French Guyana. The postoc will work on the resistance mechanism of P. falciparum on antimalarials. To read more about this position, click here.
 
Please remember also to check out the positions for field work in Senegal through Colorado University. Read more here.
 
This week disturbing figures in terms of global malaria mortality were published in The Lancet. We thought we were down to 655 thousand in 2010, but now we have a figure of 1,24 million! Read more here.
 
This week an interesting Guest Editorial from Dr. Lotte van Dijk, on counterfeit drugs. Read her story here. Read also an interesting response from Dr. Bert Nanninga on this issue here.
 
And then a thought-provoking expert blog from Mark Benedict, who comments on a publication by Dr. Christophe Boete. On how we as scientists engage with the general public. Read his story here.
 
Much more this week - find out.
 
Enjoy this week's MalariaWorld - the MW team.

Global malaria mortality between 1980 and 2010: a systematic analysis

Author(s): 
Christopher JL Murray, Lisa C Rosenfeld, Stephen S Lim, Kathryn G Andrews, Kyle J Foreman, Diana Haring, Nancy Fullman, Mohsen Naghavi, Rafael Lozano, Alan D Lopez
Reference: 
The Lancet, Volume 379, Issue 9814, 4–10 February 2012, Pages 413-431
Contact email: 
cjlm@u.washington.edu

MalariaWorldOur findings show that the malaria mortality burden is larger than previously estimated, especially in adults.

Short Report: Different Patterns of pfcrt and pfmdr1 Polymorphisms in P. falciparum Isolates from Nigeria and Brazil: The Potential Role of Antimalarial Drug Selection Pressure

Author(s): 
Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, et al.
Reference: 
Am J Trop Med Hyg 2012 86:211-213
Contact email: 
christianhappi@hotmail.com

MalariaWorldWe provide first evidence of emergence of the CVMNT haplotype in West Africa. The high prevalence of pfcrt CVIET and SVMNT haplotypes in Nigeria and Brazil, respectively, is indicative of different selective pressure by chloroquine and amodiaquine.

Open Access | Editorial: How Do We Best Diagnose Malaria in Africa?

Author(s): 
Philip J. Rosenthal
Reference: 
Am J Trop Med Hyg 2012 86:192-193
Contact email: 
prosenthal@medsfgh.ucsf.edu

MalariaWorldIn this regard, the advent of rapid diagnostic tests (RDTs) for malaria is an important advance. Multiple immunochromatographic tests, incorporating a number of different parasite antigens and produced by many different manufacturers, are now available.

Predictors of Acute Bacterial Meningitis in Children from a Malaria-Endemic Area of Papua New Guinea

Author(s): 
Moses Laman, Laurens Manning, Timothy M. E. Davis, et al.
Reference: 
Am J Trop Med Hyg 2012 86:240-245
Contact email: 
tdavis@cyllene.uwa.edu.au

MalariaWorldPredictors of acute bacterial meningitis (ABM) were assessed in 554 children in Papua New Guinea 0.2–10 years of age who were hospitalized with culture-proven meningitis, probable meningitis, or non-meningitic illness investigated by lumbar puncture.

Job: Postdoctoral Fellow: Malaria resistance research

Deadline for applications: April 30, 2012 (position open until filled)
Organisation: Institut Pasteur de la Guyane
Location: Cayenne, French Guiana

4
Average: 4 (1 vote)

False-Negative Rapid Diagnostic Tests for Malaria and Deletion of the Histidine-Rich Repeat Region of the hrp2 Gene

Author(s): 
Ousmane A. Koita, Ogobara K. Doumbo, Donald J. Krogstad, et al.
Reference: 
Am J Trop Med Hyg 2012 86:194-198
Contact email: 
krogstad@tulane.edu

MalariaWorldThe importance of these observations is likely to increase as malaria control improves, because lower MOIs are associated with false-negative RDTs and false-negative RDTs are more frequent in persons with asymptomatic infections. These findings suggest that the use of HRP2-based RDTs should be reconsidered.

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar

Author(s): 
Arsène Ratsimbasoa, Harintsoa Ravony, Didier Ménard, et al.
Reference: 
Am J Trop Med Hyg 2012 86:203-210

MalariaWorldThis study provides comprehensive data concerning the clinical cure rate obtained with artesunate-amodiaquine and evidence supporting the scaling up of home management of malaria.

Open Access | Performance of Two Malaria Rapid Diagnostic Tests in Febrile Adult Patients with and without Human Immunodeficiency Virus-1 Infection in Blantyre, Malawi

Author(s): 
Jobiba Chinkhumba, Monica Nyanda, Jacek Skarbinski and Don P. Mathanga
Reference: 
Am J Trop Med Hyg 2012 86:199-202
Contact email: 
jchinkhumba@mac.medcol.mw

MalariaWorldThe performance of two histidine-rich protein type-2–based malaria rapid diagnostic tests (mRDTs) was examined in a rural area with a high prevalence of malaria and human immunodeficiency virus type-1 (HIV-1) infection in 113 and 445 febrile patients ≥ 15 years of age with and without HIV-1 infection, respectively.

Open Access | Lack of Decline in Childhood Malaria, Malawi, 2001–2010

Author(s): 
Arantxa Roca-Feltrer, Collins J. Kwizombe, Robert S. Heyderman, et al.
Reference: 
Emerging Infectious Diseases, Volume 18, Number 2—February 2012
Contact email: 
arfeltrer@mlw.medcol.mw

MalariaWorldWe examined health facility data for children seen as outpatients and parasitemia-positive children hospitalized with cerebral malaria in a large national hospital.

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