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Last week at MalariaWorld...

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Last week blog articles focused on bednets and male mosquito mating biology, besides mosquito olfaction and trap development.
 
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Open Access | Loss of balancing selection in the beta S globin locus

Author(s): 
Niven A Salih, Ayman A Hussain, Ibrahim A Elmugtaba, Abeir M Elzein, Ibrahim M Elhassan, Eltahir AG Khalil, Hani B Ishag, Hiba S Mohamed, Dominic Kwiatkowski and Muntaser E Ibrahim
Reference: 
BMC Medical Genetics 2010, 11:21
Contact email: 
mibrahim@iend.org

Probably the best example of the rise and maintenance of balancing selection as an evolutionary trend is the role of S-haemoglobin (HbS - rs334) in protecting from malaria. Yet, the dynamics of such a process remains poorly understood, particularly in relation to different malaria transmission rates and the genetic background of the affected populations.

An assessment of Lot Quality Assurance Sampling to evaluate malaria outcome indicators: extending malaria indicator surveys

Author(s): 
Caitlin Biedron, Marcello Pagano, Bethany L Hedt, Albert Kilian, Amy Ratcliffe, Samuel Mabunda, and Joseph J Valadez
Reference: 
Int. J. Epidemiol. 2010 39: 72-79
Contact email: 
pagano@hsph.harvard.edu

This article demonstrates the feasibility of integrating LQAS into multistage cluster sampling surveys and using these results to support a comprehensive national, regional and local programme M&E system.

Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

Author(s): 
Spencer C. Maughan, Maciej Pasternak, Christopher S. Cobbett, et al.
Reference: 
PNAS February 2, 2010 vol. 107 no. 5 2331-2336C
Contact email: 
smaughan@venrock.com

We conclude that these transporters play a significant role in regulating GSH levels and the redox potential of the cytosol.

Open Access | Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion

Author(s): 
Lubin Jiang, María José López-Barragán, Hongying Jiang, Jianbing Mu, Deepak Gaur, Keji Zhao, Gary Felsenfeld, and Louis H. Miller
Reference: 
PNAS February 2, 2010 vol. 107 no. 5 2224-2229
Contact email: 
ljiang@niaid.nih.gov

Our data indicate that the failure of Dd2 to express the sialic acid-independent invasion receptor gene RH4 is associated with the epigenetic silencing mark H3K9 trimethylation present throughout the cycle.

Assessment of the Impact of Climate Shifts on Malaria Transmission in the Sahel

Author(s): 
Arne Bomblies and Elfatih A. B. Eltahir
Reference: 
EcoHealth, Online First
Contact email: 
abomblie@uvm.edu

We seek to evaluate the impact of hypothetical climate change scenarios on malaria transmission in the Sahel by using a novel mechanistic, high spatial- and temporal-resolution coupled hydrology and agent-based entomology model.

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

Author(s): 
Devdutt Chaturvedi, Abhishek Goswami, Partha Pratim Saikia, Nabin C. Barua and Paruchuri G. Rao
Reference: 
Chem. Soc. Rev., 2010, 39, 435 - 454

It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

Commentary: Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?

Author(s): 
S Parikh and P J Rosenthal
Reference: 
Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162
Contact email: 
sparikh@medsfgh.ucsf.edu

We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.

Age-dependent association between IgG2 and IgG3 subclasses to Pf332-C231 antigen and protection from malaria and induction of protective antibodies by sub-patent malaria infections, in Daraweesh

Author(s): 
Hayder A. Giha, Amre Nasr, Nnaemeka C. Iriemenam, Halima A. Balogun, David Arnot, Thor G. Theanderf, Marita Troye-Blomberg, Klavs Berzins and Gehad ElGhazali
Reference: 
Vaccine, Volume 28, Issue 7, 17 February 2010, Pages 1732-1739
Contact email: 
gehaha2002@yahoo.com

In conclusion, this report suggests a protective effect for IgG subclasses to Pf332-C231 antigen against malaria.

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