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Home › Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Submitted by Kabogo on March 5, 2010 - 09:10
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Author(s): 
Lin Zhou, André Alker, Jonathan L. Vennerstrom et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1555-1558
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Contact email: 
jvenners@unmc.edu

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

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