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Home › Mechanisms of Resistance: Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

Mechanisms of Resistance: Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

Submitted by Kabogo on June 18, 2010 - 09:38
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Author(s): 
Benoit Witkowski, Marie-Laure Nicolau, Patrice Njomnang Soh, Xavier Iriart, Sandie Menard, Muriel Alvarez, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, and Antoine Berry
Reference: 
Antimicrobial Agents and Chemotherapy, July 2010, p. 3049-3051, Vol. 54, No. 7
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Contact email: 
berry.a@chu-toulouse.fr

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as possible.

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