The polio vaccination was discovered in 1952, announced to world in 1955. A global effort to eradicate polio, led by the World Health Organization, UNICEF, and The Rotary Foundation, began in 1988. Using today, December 9, 2013 as a starting point, how long would it take to eradicate malaria worldwide?
Acoustic Larvicide is a technique where mosquito larvae are killed by rupturing their internal air bladders with acoustic energy. Their air bladders are resonant and therefore susceptible to acoustic energy in the octave from 18 kilohertz to 30 kilohertz. When sound at these frequencies with sufficient energy is put in the water the mosquito larvae instantly die.
This company, New Mountain Innovations appears to be the leader of this idea. Larvasonic.com
A recent paper (Anti-Plasmodial Polyvalent Interactions in Artemisia annua L. Aqueous Extract - Possible Synergistic and Resistance Mechanisms J J Suberu et al., PLoS ONE, November 2013 8 |11) opens the way for new antimalarial therapies. It gives an answer to several questions which had not been addressed properly in the scientific literature. The paper studied the additive, synergistic or antagonistic effect of several constituants of Artemisia annua. It confirms clearly that the aqueous extract of Artemisia annua is 3x as potent as pure artemisinin.
Sumitomo Chemical, Olyset Net maker, was accused of bribery.
The article “Cambodia investigates Sumitomo Chemical subsidiary in bribery case” was found in the Asahi .
Is this just the tip of iceberg?
On 6 November 2013, WHO/ PAHO honoured initiatives from three malaria-endemic countries with the ‘Malaria Champions of the Americas Awards’. The Malaria Champions of the Americas awards were given to Colombia (Colombia Malaria Project), the Dominican Republic (National Center for Control of Tropical Diseases), and Brazil (Secretariat of Health of the State of Acre). The Malaria Champions of the Americas was launched in 2008 to identify, celebrate and inspire excellence in efforts to fight the disease.
Scientific Organizers: Pedro L. Alonso, Chetan E. Chitnis and Lee Hall
The plasmodium parasite needs cholesterol for survival and multiplication. The replicative capacity of plasmodium liver forms is remarkable, achieving the fastest growth rates known.
We are very excited to be connecting with you through MalariaWorld. The Malaria Eradication Scientific Alliance – MESA - will feature the ever growing evidence base in malaria elimination, from science, to lessons learned, and policy.
In commemoration of Malaria Day in the Americas 2013
The Pan American Health Organization,
The Pan American Health and Education Foundation, and
The Center for Global Health at The George Washington University
Cordially invite you to attend the
Malaria in the Americas Forum 2013:
Haemolytic, hepatotoxic, cytotoxic, neurotoxic, cardiotoxic, genotoxic, ototoxic, embryotoxic, spleenotoxic, hemolytic, atherosclerosis, immunodepressive effects of chemical artemisinine derivatives (ACTs) at high doses.
Some recent research, mostly in relation with the resistance to ACT pills and/or artesunate injections, has highlighted serious secundary health effects at the doses prescribed by WHO.
Date: February 2-7, 2014
Location: Mérida, Yucatán, México
Scientific Organizers: Pedro L. Alonso, Chetan E. Chitnis and Lee Hall
Organized in collaboration with MESA – Malaria Eradication Scientific Alliance
Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. Click for the Program and more information .
Artemisia ketone is the major constituent of essential oil of many artemisia plants, often up to 60 %. A lot of research work has been devoted to other constituents like artemisinin, scopoletine, limonene, eucalyptol, borneol, luteolin, eupatin, casticin, but artemisia ketone is completely absent in the scientific literature. The molecule had been discovered in Artemisia annua in 1938 ( WA Jacobs et al., Annual Review of Biochemistry 7,1-193) but then fell into oblivion.
I am a civil engineer with experience in drainage and flood control. Drainage and flood control infrastructure can be an important part of integrated pest management as a means for larval source management.
Unfortunately, the related drainage infrastructure for a diked area typically has a number of drawbacks: 1) during dry periods, the drainage system for the low-lying land protected by the dike will inevitably include areas of stagnant water; 2) the lowered water table will cause the land to subside - which will make gravity drainage more difficult and produce more stagnant water; and 3) wetland environments will be severely degraded, harming flora and fauna.
Diked areas adjacent to tidally-influence watercourses can use tidal water level variations to significantly reduce stagnant water in the drainage system; reduce subsidence; and enhance wetlands.
Click on Read More for a paper I wrote which was published the August edition of Outlooks on Pest Management.
For a copy of the entire article in pdf format including photos, please contact me via e-mail at email@example.com.
Recent results obtained at the AlQuds University in partnership with IFBV-BELHERB from Luxembourg show that freshly prepared infusion of Artemisia annua is stronger than chloroquine in the inhibition of beta-hematin (hemozoin) formation. In the infected erythrocyte the malaria parasite generates large quantities of toxic heme which it has to render innocuous by polymerizing it into hemozoin. The mechanism of quinine and all its derivates, chloroquine, amodiaquine operates by inhibiting this hemozoin crystallization.
I was asked by a friend, who is not a malaria scientist (in fact, not a scientist at all) to imagine the following situation:
You were chosen by a malaria endemic country to direct their fight against the disease. The government of the country tells you they will adopt three strategies to fight it, solely based on your recommendations. What would those be?
My name is Mercè and I'm from Barcelona, Spain.
I'm a veterinarian with a tropical medicine master's degree and I work mostly on malaria diagnosis.
Over the past years I have been working in Africa, training laboratory technicians in diagnosis of tropical diseases, especially malaria.
I have also worked with health ministries in the implementation of quality control programs and monitoring of malaria diagnosis.
I have been working as a consultant with various organizations and I am currently looking for work.
A paradigm change
It was always believed that resistance is provoked by antimalarial drugs; they cause plasmodium to evolve and become tougher. Consequently it was important to kill the last parasite to avoid recrudescence. But Andrew Read (Conference Evolution, Utah, June 21-25 2013) finds that in a weakened immune system parasites multiply to extremely high densities. This pool of parasites contains a larger number of mutants, upping the chances of some having greater virulence potential.
No sane African, with due knowledge of history, should try to eradicate Mosquitoes and Malaria, unless they have a sound alternative to defend the continent.
Authors: Constant Kansango Tchandema and Pierre Lutgen
G6DP (glucose-6-phospate dehydrogenase) deficiency is a genetic disease which may lead to hemolysis.
WE are astonished that only 50 of the 7917 malaria experts on www.malariaworld.org have an opinion on synthetic artemisinin production and the impact this may have on farmers in poor countries. Somebody sent us yesterday the blog “Why Synthetic Artemisinin Is Still a Bad Idea “ from Jim Thomas of the ETC Group. Hereafter a few excerpts which deserve consideration
A recent paper (K van Acker, J Plaizier, Malaria Journal, 2012-11 Suppl.1) confirms the concern raised by previous publications: “Stability of artemisinin derivatives has so far only been partially investigated and it is unclear how much this contributes to the reports of bad quality or substandard antimalarials” One of the conclusions of this study is that” Artesunate and amodiaquine can only be used in a fixed dose combination if they are physically separated”.
To all MalariaWorld readers, does anyone know of ANY country that has been certified malaria-free by WHO and where the eradication campaign has been managed or controlled by an outside agency. If yes, please state the country when replying.
It would help a great deal if MalariaWorld readers would reply or comment so that I would know this blog has at least been read or considered. Please don't remain silent. Silence can lead to the equivalent of misinformation in this case.
Either a 'No' or a 'Yes + country' will suffice.
I wish to consider the situations prevailing in those countries where within the last 90 years, malaria had previously been endemic but which countries have since been certified by WHO as malaria-free. In particular, I wish to examine generally whether or not the methods of eradication were initiated/directed/managed/controlled on a daily basis by persons of that country OR by persons from outside agencies.
Sad to see all the usual suspects of funding delays, cutbacks, security concerns, and poor ITN lifespans colliding:
Can anyone on the ground in Madagascar comment? When is the main transmission season, etc?
Who can tell me where I can find good LLIM mosquitonets for a good price.
We need about 2500 nets for 19 villages in Malawi.
If I do nou buy in Malawi, do we have to pay a certain tax and VAT importing in Malawi?
Thank you for your help.
Cris van Beek
Ritas kleine Schritte in Malawi (small steps)
The Makerere University at Kampala has been able to demonstrate over the recent years that the regular consumption of Artemisia annua tea may lead to a strong preventive effect against malaria. ( PE Ogwang et al., Trop J Pharmac Res, 2012,13:3, 445-453; PE Ogwang et al., Brit J Pharmac Res 201, 1 :4, 124.132). This research effort sponsored by government of Uganda and Carnegie corporation USA, has led to the development of drug called Artavol® which is now available in pharmacies in Uganda. This product contains ingredients from three medicinal herbs.
I was wondering if any of your friends has sent you this link and asked you why we don't want the MMS miracle to be spread around... I'm still confused, not knowing if I should laugh or cry. But I'm inclined to cry...
Two competing chemotypes.
Already twenty years ago the possibility of two chemotypes for Artemisia annua had been suggested ( HJ Woerdenbag et al., Flavour and Fragrance Journal 8, 1993, 131-137) distinguishing between a Chinese and a Vietnamese chemotype, the former containing 0.17 artemisinin, the latter 1.0%.
D Fulzele et al. ( Phytotherapy Research , 5, 1991, 149-153) found that plants from Europe produced the highest level of artemisin and those from Lucknow produced the highest level of arteannuin-B.