“The years teach much that the days never knew” (Unknown source)
It has been puzzling why the architect of the start of the first successful national malaria-eradication campaign anywhere in the world, Dr I Kligler, should have been forgotten, and his work, until recently, almost unknown.
“The years teach much that the days never knew” (Unknown source)
Cambodia is moving towards eliminating malaria. According to the WHO World Malaria Report, less than 100 deaths were attributable to malaria in 2012 (World Malaria Report 2013).
In the 1970s, there were only about nine countries where dengue fever existed but now the number is closer to 60. As of 2010 dengue fever is believed to infect 50 to 100 million people worldwide per year with 1/2 million life-threatening infections There is no cure and no real treatment.
I am pleased to see that Pedro will take over the hard task that Rob Newman left. Rob was instrumental in bringing the Global Malaria Programme back to life, and now I would like to see it expand its influence. When one looks at the various malaria control operations in various countries and read the various blogs etc, it is apparent that there is a lack of coordination, and in most instances there are several agencies, donors, major players and national personalities operating.
About two years ago i met a friend who introduced me to the Bahai Faith, before then i had been a dormant Presbytarian. The ideals of the Bahai Faith have had so much impact in my life as a person. Anyhoo i came across this article, thought i would share it with you all.
At the 15th International Workshop on Clinical Pharmacology of HIV on May 19, 2014 at the University of Nebraska, FA Fehintola showed that nevirapine co-prescribed with artemether-lumefantrine may reduce the artemether concentration in blood by 70%.
A document in Scientific American (June 2014) describes the activities of MVV Medecines for Malaria Ventures, a « non profit » organization (association sans but lucratif) located at Geneva. It is surprising to learn that they sell Artesunate in monotherapy for intravenous injection at high doses ; in cooperation with WHO and Médecins sans Frontières.
- A global elimination plan, supported by international health bodies.
- Thorough costings and tools to support the business case.
- An approach that is positioned within a development framework.
- Core elimination advocacy messages.
- Provision of advocacy tools for partners.
- Extensive and effective community engagement.
- Strong partnerships
Dear friends & colleagues,
I am extremely honoured, proud, and happy to announce that I have been awarded a prestigious Vidi grant from the Netherlands Organisation for Scientific Research (NWO) to start my own independent malaria research lab in Nijmegen. Below follows a press release providing further details.
Why is there so little blogging about malaria from a local perspective? Those who live in regions of endemic malaria are not writing about it. As a result, it is hard to follow progress in combating malaria in a particular region. For example, I have an interest in malaria in western Kenya. However, it is difficult to know what programs are in place there, who is involved, what progress has been made. I am willing to bet that there is not a single blog anywhere where people living in an endemic region talk about malaria.
------------- Enquête sur le diagnostic du neuropaludisme--------------------
Nous sommes un groupe de médecins de l'université Duke aux États-Unis et de l'Université de Liverpool au Royaume-Uni. Notre objectif étant de mieux comprendre comment les médecins parviennent à poser un diagnostic de neuropaludisme, nous avons réalisé une enquête à ce sujet.
A group of French tourists, while crossing Africa by car, noticed that those drinking Artemisia annua tea where less attacked by the fierce mosquitoes of this continent than those relying on the standard pharmaceutical pills.
Wherever malaria has been eliminated, success was likely to have been based on the interplay of a series of mechanisms. In the United States it may have coincided with the advent of residual insecticides, but there were a variety of factors associated with the success. These were seasonal changes, environmental factors, political decisions that affected where people could live, the advent of improved treatments and increase in wealth and improvement of living standards. The same can be said of Italy and much of Europe in the early part of the 20th Century.
It all begins in 1952 with the work of the Liverpool School of Tropical Medicine (BG Maegraith et al, British Medical Journal, 1952, 1382-3). They found that in rats inoculated with Plasmodium berghei and living on a diet of milk there was a strong suppression of the growth of the parasites. This was valid for retail whole cow’s milk, reconstituted dried milk from different origins and human milk. Most rats on normal laboratory diet died in a few days.
The mode of action of quinine and chloroquine is almost exclusively based on the inhibition of the crystallization of heme into hemozoin, killing plasmodium in its own digestive rejects. In several papers M Akkawi from the Al Quds University in Palestine has shown that extracts of several medicinal plants : Salvia officinalis, Artemisia sieberi, Artemisia afra, Artemisia annua, Inula viscosa had similar effects, in some cases equivalent or better than chloroquine for the inhibition of beta-hematin (see literature references below).
In the April 2014 issue the magazine Rotary Contact from Belgium-Luxembourg duly recognized he efforts and results achieved by Rotarians from Ieper and Luxembourg in the promotion of Artemisia annua tea against malaria. Geert Flamang has launched plantations in Katanga and Pierre Lutgen has run clinical trials in several African countries which demonstrate an efficiency of >95%. These trials have allowed to show that the antimalarial potency can be increased by using the dried leaves in lieu of aqueous extracts, as powder in capsules or mixed with food.
I feel that we should start a conversation about coordination. I attended Malaria Day here in Baltimore last week, and one still hears people speaking as if all we have to do is send more nets to Africa! Africa is swimming in nets, in fact there are NO plans that one hears of to REPLACE (key word) expended of torn nets in anything but an ad hoc manner. Yet Anopheles funestus (resistant to pyrethoids) is appearing all over Eastern and Southern Africa.
It is World Malaria Day today (Friday 25 April), and to help raise awareness there are two new Special Collections available from The Cochrane Library - one for malaria diagnosis and treatment, and one for prevention and control.
A new open access Cochrane Review was released earlier this month by John Odaga et al. that may be of interest to Malaria World members:
Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings
Integrated Community Case Management (iCCM) is a strategy that enables those living beyond the reach of health facilities to access lifesaving treatments. It should be a national priority and an integral part of national health sector plans, a recent symposium in Ghana has concluded.
New operational research projects in malaria elimination will start this April, after being selected for funding through MESA. The MESA operational research portfolio includes: proof-of-concept of novel vector control and diagnostic tools, use of mapping technologies for surveillance and tailored response, and mobile phone applications for hard to reach populations. Urban, rural and forest settings are addressed. The projects are summarised here.
Recently, we at the Cochrane Infectious Diseases Group (CIDG) have published several systematic reviews of malaria interventions which may be of interest to Malaria World members. Each of the reviews are open access and are listed below:
• Mass drug administration for malaria
• Larvivorous fish for preventing malaria transmission
PSI is seeking an experienced, dynamic Deputy Director of its Malaria and Child Survival Department (MCSD) to oversee PSI’s rapidly expanding portfolio of MCS programs. PSI is one of the largest global health organizations and its malaria and child survival programs account for about half of its business.
Sir Ronald Ross discovered the seeds of malaria on the gut walls of a mosquito. What was the species? Was it An. stephensi or An. rossi? Has the riddle been already solved? Please share your thoughts.