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Malaria eradication: Lessons from Israel and a tribute to Prof. Israel Kligler

April 13, 2014 - 17:49 -- J20 Jerusalem Conf
“Why has the Anti-Malarial work in Palestine been so successful?”
 
In 1925, the Malaria Commission of the League of Nations, after visiting Palestine, posed this question to itself. To which their written reply in 1925 was:
 
“In the first place, because evidence was available to prove that it was so. That is principally due to the thorough anti-malarial survey carried out everywhere before the work begun.”

Treatments in remote areas urgent to meet Millennium Development Goals

April 11, 2014 - 15:34 -- Debora Miranda

Integrated Community Case Management (iCCM) is a strategy that enables those living beyond the reach of health facilities to access lifesaving treatments. It should be a national priority and an integral part of national health sector plans, a recent symposium in Ghana has concluded.

New: MESA operational research grants start activities

April 10, 2014 - 22:15 -- MESA Alliance

New operational research projects in malaria elimination will start this April, after being selected for funding through MESA. The MESA operational research portfolio includes: proof-of-concept of novel vector control and diagnostic tools, use of mapping technologies for surveillance and tailored response, and mobile phone applications for hard to reach populations. Urban, rural and forest settings are addressed. The projects are summarised here.

Open access Cochrane Reviews of malaria interventions

April 8, 2014 - 15:42 -- Dee Walshe

Hello,

Recently, we at the Cochrane Infectious Diseases Group (CIDG) have published several systematic reviews of malaria interventions which may be of interest to Malaria World members. Each of the reviews are open access and are listed below:

• Mass drug administration for malaria

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008846.pub2/abstract

• Larvivorous fish for preventing malaria transmission

Are in vitro antimalarial assays a waste of time?

March 22, 2014 - 08:59 -- Pierre Lutgen

by Patrick Engeu Ogwang and Pierre Lutgen

Most of the assessments on the antimalarial efficacy of a molecule are made in vitro. In the case of plant material the first step is generally the extraction with an organic solvent. The extract is then lyophilized, frozen and stored for subsequent trials.

Malaria testing not a simple fix in the private sector

March 21, 2014 - 12:22 -- Debora Miranda

Drug shops offering quick diagnostic tests for malaria can improve treatment, but regulation by authorities is also needed, researchers warn.

Read the story and the article at: http://www.actconsortium.org/news.php/66/malaria-testing-not-a-simple-fix-in-the-private-sector

Malaria rapid diagnostic tests (RDTs) are simple tools to diagnose malaria accurately and can help health workers in remote locations to prescribe the correct treatment. But introducing RDTs into the private sector may have complex, unexpected consequences for patients.

Malaria testing not a simple fix in the private sector

March 21, 2014 - 12:21 -- Debora Miranda

Drug shops offering quick diagnostic tests for malaria can improve treatment, but regulation by authorities is also needed, researchers warn.

Read the story and the article at: http://www.actconsortium.org/news.php/66/malaria-testing-not-a-simple-fix-in-the-private-sector

Malaria rapid diagnostic tests (RDTs) are simple tools to diagnose malaria accurately and can help health workers in remote locations to prescribe the correct treatment. But introducing RDTs into the private sector may have complex, unexpected consequences for patients.

Last week at MalariaWorld: Sad news & more...

March 21, 2014 - 11:25 -- Last week at Ma...
With great sadness we have to inform you that on the 16th of March Ernst-Jan Scholte, 40 yrs, passed away. With E.J. we lose a dear colleague who was a pioneer in the use of entomopathogenic fungi for the control of mosquitoes. We have come to know E.J. as a passionate professional, a talented guitar player and a very gentle person. E.J. once was one of Bart’s students and stayed for some months with Bart and Inga during his internship in Kenya in 1998. Read Bart’s personal story about E.J. here. 
 
We wish his wife, Patrizia, and his two children, Sofia and Stefano, all the strength they need.

Do you see patients with cerebral malaria? ...Or know someone who does?

March 21, 2014 - 11:16 -- Lakshmi Swamy

If you care for patients with cerebral malaria or know someone who does, then we would appreciate your help in distributing this short survey.
Please use the following link to complete the survey: Cerebral Malaria Diagnosis Survey

I am an ophthalmologist with a background in malaria biology, and I am leading a survey study to understand how clinicians diagnose cerebral malaria.

Free International Innovation publication with special focus on malaria

March 20, 2014 - 18:00 -- MESA Alliance

International Innovation, has recently published an edition called 'Parasites of poverty: how international research is tackling the global threat of tropical disease'. In this edition there is a special focus on malaria: 'break the life cycle stop the spread."

In search of a postdoc position

March 19, 2014 - 15:07 -- Roy Faiman

Hello colleagues!
I'll be finishing a one-year postdoc at Cornell university.
My work here focused on behavioral assays on Aedes albopictus to try and improve our understanding of visual cues that aid the gravid females in locating and selecting an oviposition site.
As of July 1st I will available to begin a new position.
My masters and PhD work (Alon Warburg's lab, The Hebrew University of Jerusalem) involved sand fly ecology and control and leishmaniasis transmission dynamics in an emerging focus. My publications are available on line.

WHO really wants to end Malaria?

February 28, 2014 - 04:49 -- Satoko Noritake

It might be a primary mistake to employ chemicals to control Malaria, or it might be because of egoism in developed countries: people who want to sell their chemical products, who need money to operate their own institutions. I recently read a book “Neem can save the earth” written in Japanese. Neem extracts have a lot of possibility to be utilized in malaria control and agriculture.

Tea against ACT: David against Goliath

February 15, 2014 - 10:38 -- Irene Teis

This PhD thesis of A Sanner, Université de Nancy 1, clearly describes why Artemisia annua tea has no chance against the business of ACT pills and why WHO issued a veto on clinical trials with the herb. Full text on http://docnum.univ-lorraine.fr/public/SCDMED_T_2008_SANNER_ALEXANDRE.pdf

Imperfect tools applied to control malaria may still lead to remarkable results

February 9, 2014 - 20:31 -- MESA Alliance

'The science of malaria eradication' Keystone Symposia

Wednesday  Feb 5th

The third day at the Keystone Symposium on The Science of Malaria Eradication was an action packed day of exciting discussions on vaccines and tools to measure transmission, with an interlude to the Mayan ruins of Mayapan, where the malaria community rhetorically climbed the 'Mayan pyramids' of eradication.

If malaria elimination is a stable state, how do we get there?

February 6, 2014 - 17:52 -- MESA Alliance

'The science of malaria eradication' Keystone Symposia

Tuesday Feb 4th

The Keystone Symposium on The Science of Malaria Eradication entered its second day of activities with a focus on drug based strategies and health systems research in the elimination context. The evidence for use of single dose primaquine to clear P. falciparum infections, the new K-13 artemisinin resistance marker, and how clearing asymptomatic infections in children can improve cognition and reduce transmission all featured in the animated discussions.

Uric acid: emerging as key factor in malaria

February 6, 2014 - 17:09 -- Pierre Lutgen

Plasmodium falciparum-infected erythrocytes contain large quantities of uric acid precipitates. These precipitates are present in the parasitophorous vacuole, in the cytoplasm, not in the food vacuole of the parasite. Uric acid precipitates are highly inflammatory molecules that are considered a danger signal for innate immunity and are the causative agent of gout. Hypoxanthine is a metabolic precursor of uric acid and is essential for Plasmodium growth. It is transformed by the xanthine oxidase into xanthine the true precursor of uric acid.

'It always seems impossible until it is done' – Nelson Mandela

February 5, 2014 - 20:51 -- MESA Alliance

'The science of malaria eradication' Keystone Symposia
Monday Feb 3rd

From bioethical considerations, to mapping trends in malaria transmission with basic biology. From inspiring lessons in other eradication campaigns, to regulatory issues around tools which benefit populations, to novel genetic technologies which modify mosquitoes and the parasite life cycle. The first day of the Keystone Symposium on the science of malaria eradication set the scene for sharing and debating new discoveries and innovative approaches to malaria eradication.

Kick-off to the 'The science of malaria eradication' Keystone Symposia

February 3, 2014 - 21:05 -- MESA Alliance

Sunday Feb 2nd


'The science of malaria eradication' Keystone Symposia celebrated its first day of activities in Merida, Yucatan, with a workshop devoted to students and researchers from endemic countries that received a travel award to attend the meeting.  This workshop offered the opportunity to interact with a group of international experts that discussed the role of a dynamic biomedical research agenda, including aspects relating to therapeutics, vector biology and vaccines to interrupt transmission.

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of the September 2013 meeting

January 24, 2014 - 17:07 -- MESA Alliance
Tags: 

The Malaria Policy Advisory Committee to the World Health Organization held its fourth meeting in Geneva, Switzerland from 11 to 13 September, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting. MESA is partnering with Global Malaria Programme to disseminate the report.

Background reading Keystone Symposium The Science of Malaria Eradication, February 2-7, 2014 Mexico

January 22, 2014 - 17:06 -- MESA Alliance

Find the background reading for the Keystone Symposium here, for those long hours in the plane!

B. Fenton Hall and Anthony S. Fauci (2009)
The Journal of Infectious Diseases 2009;200:1639–43
 
malERA group: Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, et al. (2011)
PLoS Med 8(1): e1000406
 
Sibao Wang and Marcelo Jacobs-Lorena (2013)
Trends in Biotechnology, March 2013, Vol. 31, No. 3
 
Ashley J. Birkett, Vasee S. Moorthy, Christian Loucq, Chetan E. Chitnis and David C. Kaslow (2013)
Vaccine, Volume 31, Supplement 2, 18 April 2013, Pages B233–B243

Palestinians discover local plant with surprisingly strong antimalarial properties.

January 20, 2014 - 13:25 -- Pierre Lutgen

The research team from the Al Quds University has already shown that some plants from Palestine have a strong inhibitory effect on beta-hematin crystallisation. Salvia officinalis (M Akkawi et al., Malaria Journal, 2012, 11-Suppl,P3) and Artemisiasieberi from Palestine ( M Akkawi et al. Brit J Pharmacol Toxicol, accepted 2013). The therapeutic effect of quinine, chloroquine, amodiaquine is precisely based on hemozoin inhibition.

The digestive vacuole and malaria resistance ; the weakness of artesunate.

January 9, 2014 - 11:04 -- Pierre Lutgen

The diffusion of antimalarials into infected red blood cells has been studied by several authors. For example, three times more chloroquine accumulates in CQ sensitive strains than in the CQ resistant ones (KJ Saliba et al., Biochem Pharmacol. 1998, Aug 1 ;56, 313-20) Thediffusion of artemisinin into parasitized RBCs was found to be rapid, saturable, temperature dependent, irreversible. In contrast, simple passive diffusion of artemisinin was seen in nonparasitized RBCs.(N Vyas, Antimicro Ag Chemother, Jan 2002, 105-109).

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