Our CTO and Co-founder David Mendels answers our most commonly asked question.
Our CTO and Co-founder David Mendels answers our most commonly asked question.
The paper « Efficacy of a Novel Sublingual Spray Formulation of Artemether in African Children with Plasmodium falciparum Malaria » (Daryl Bendel et al.,Antimicrob. Agents Chemother. November 2015 vol. 59 no. 11 6930-6938) which was posted recently on www,malariaworld.org raises this important question. The clinical trials were run by an Australian pharmaceutical company in Burkina Faso, Rwanda and Ghana
In view of the tragedy, the barbarity and shocking loss of life in Syria, I felt this may be a timely reminder about how malaria elimination was, and could still be, a huge inspiration to all mankind and an aid towards a calmer and more peaceful world.
Countries known to have ebola are avoided by tourists because people die of it, and recently this disease has been given much media attention.
Charlwood JD, Wilkes TJ. Studies on the age composition of Anopheles darlingi Root from Brazil. Bulletin of Entomological Research, 1979 67, 337-342.
Working on Anopheles darling with the great Tony Wilkes – perhaps best person that I know, and, apart from Gillies, certainly the best field entomologist that I have known. An enormous influence on yours truly, not just in terms of entomology and how to approach field work but how to approach life.
Would anyone please explain why the example below of a successful method of malaria elimination is not being followed elsewhere?
When IBM dominated the computer world in the 1970s, an expression arose ‘No-one was ever fired for buying IBM’, even though competitors’ machines may have been more suitable for the task. Has a similar attitude now arisen towards bednets by those considering malaria elimination? Is the default position with regard to malaria elimination ‘No-one ever gets fired for buying mosquito bednets’? By 1970, Malaria was eliminated in North America and Europe. Were bednets extensively used there?
The quest for the anti-malaria ‘silver-bullet’/’magic-bullet’ drug or vaccine. Has this confused, distracted, mesmerised or misled the practical (cf theoretical lab-based) anti-malaria scientists?
Google’s definition of ‘Silver Bullet’ includes “ A simple remedy or a quick solution for a difficult problem”. Simple. Quick. And its definition of ‘Magic Bullet’ includes “A drug or treatment that cures a disease quickly and easily without producing bad effects”. Quickly. Easily.
Tomnod has teamed up with the University of California San Francisco's Malaria Elimination Initiative to develop a population map of Swaziland to assist in planning and implementing malaria elimination activities.
Tomnod uses DigitalGlobe satellite imagery to engage online volunteers to scan small portions of a large area. The volunteers scan the imagery and mark locations of interest to that particular survey. In this case the survey is looking for villages across Swaziland. When buildings are spotted by a volunteer in a polygon, that polygon is marked.
On 7th August 2012, Bart Knols brought to our attention a lecture by Margaret Heffernan entitled ‘Dare to Disagree’, and which can be seen at http://www.malariaworld.org/blog/margaret-heffernan-must-see-all-mw-subscribers . Margaret Heffernan spoke amongst other things about a scientist, Alice Stewart, who, in the 1950s, investigated and demonstrated the incidence of childhood cancer and its connection with the practice of X-raying pregnant women.
LLIN, new products and the impact of/ on insecticide resistance
In the past 15 years malaria mortality and morbidity rates have been halved. This owes not least to insecticide based interventions and in particular the Long Lasting Insecticidal Net (LLIN). In recent years increased findings of insecticide resistance have caused serious concerns whether these advances are threatened, although how much and how to respond remain topics for discussion.
This article will focus on the improved likelihood of a successful outcome where malaria elimination is conducted by scientists who live in the affected area. The blog by Alvaro Pemartin of 22nd January 2015 entitled "Column: Public health concerns (too) far away from home. Who cares?" is both instructive and fascinating. He showed statistics that revealed the global burden of swine flu, avian flu and ebola is far lower than the losses caused by malaria. He demonstrated that the media seems to overlook this point.
As is seen from the picture below, the national malaria elimination campaign, begun in 1922 in Palestine, clearly worked.
For different aspects of this campaign generally, see Aspects of the malaria elimination .
But in particular, for what was so unique that made this malaria elimination so durable, see Durability .
Many low and middle-income communities still lack affordable and scalable solutions for their priority health needs. We are aiming to improve generation of new ideas and technological innovation by early-career researchers in Africa, specifically in the health sector. As a step in the process, we wish to conduct an analysis of expert opinion on best strategies for encouraging these early-career scientists so that they can better identify priority health problems in their communities, and generate new ideas to address these problems.
We've had a good start to the new year here at the Cochrane Infectious Diseases Group (https://cidg.cochrane.org/), with one new Cochrane Review and one new Cochrane Protocol published, which may be of interest to Malaria World members.
2015, Issue 1 (Cochrane Reviews and Protocols published 1 to 31 January 2015):
New Cochrane Review: Intermittent preventive antimalarial treatment for children with anaemia (Athuman M, Kabanywanyi AM, Rohwer AC)
I had written on this topic sometime ago. My present research on dams and malaria in Africa triggered me to invoke some more thoughts (http://www.malariajournal.com/content/14/1/339). Several dams are under construction in sub-Saharan Africa. According to FAO database, some 118 dams are currently under construction while several more are planned. My analysis indicated that over half (57%) of these dams are located in areas with unstable/seasonal malaria. Previous studies indicated that dams in unstable semi-arid areas intensify malaria transmission.
The competitive product Artequick which the Chinese launched against Coartem and Coarsucam is now confronted by resistance like any other monotherapy. A letter to the editor by DL Saunders et al., in NEJM July 2014 describes the dihydroartemisinin-piperaquine failure in Cambodia. The drug was adopted as first line treatment in this country in 2010. Three years later the efficacy has decreased from 92% to 64%. At 72 hours 56% of patients still had persistent parasitemia.
As this year is the centenary of the start of World War 1, perhaps readers may be interested to see how malaria may have changed the outcome of the war had the Turkish army managed to hang on after the last battle in 1918, as the British Army collapsed from malaria two weeks after that battle. See http://www.eradication-of-malaria.com/ww1-malaria.html This may be used to serve as a reminder to those who choose to ignore the disease and treat it casually.
Osana is a small, all natural anti mosquito soap. You simply wash with this bar of soap to keep mosqito away.
We are passionate about providing a non toxic solution to protect people naturally, as well as creating a sustainable product with no negative side effects.
Several recently published Cochrane Reviews from the Cochrane Infectious Diseases Group may of interest to Malaria World members:
Artemether for severe malaria (new review) http://ow.ly/CEOQi
Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment (updated review) http://ow.ly/CEPri
“The years teach much that the days never knew” (Unknown source)
I am pleased to see that Pedro will take over the hard task that Rob Newman left. Rob was instrumental in bringing the Global Malaria Programme back to life, and now I would like to see it expand its influence. When one looks at the various malaria control operations in various countries and read the various blogs etc, it is apparent that there is a lack of coordination, and in most instances there are several agencies, donors, major players and national personalities operating.
About two years ago i met a friend who introduced me to the Bahai Faith, before then i had been a dormant Presbytarian. The ideals of the Bahai Faith have had so much impact in my life as a person. Anyhoo i came across this article, thought i would share it with you all.
A document in Scientific American (June 2014) describes the activities of MVV Medecines for Malaria Ventures, a « non profit » organization (association sans but lucratif) located at Geneva. It is surprising to learn that they sell Artesunate in monotherapy for intravenous injection at high doses ; in cooperation with WHO and Médecins sans Frontières.
Dear friends & colleagues,
I am extremely honoured, proud, and happy to announce that I have been awarded a prestigious Vidi grant from the Netherlands Organisation for Scientific Research (NWO) to start my own independent malaria research lab in Nijmegen. Below follows a press release providing further details.
Why is there so little blogging about malaria from a local perspective? Those who live in regions of endemic malaria are not writing about it. As a result, it is hard to follow progress in combating malaria in a particular region. For example, I have an interest in malaria in western Kenya. However, it is difficult to know what programs are in place there, who is involved, what progress has been made. I am willing to bet that there is not a single blog anywhere where people living in an endemic region talk about malaria.
------------- Enquête sur le diagnostic du neuropaludisme--------------------
Nous sommes un groupe de médecins de l'université Duke aux États-Unis et de l'Université de Liverpool au Royaume-Uni. Notre objectif étant de mieux comprendre comment les médecins parviennent à poser un diagnostic de neuropaludisme, nous avons réalisé une enquête à ce sujet.
Wherever malaria has been eliminated, success was likely to have been based on the interplay of a series of mechanisms. In the United States it may have coincided with the advent of residual insecticides, but there were a variety of factors associated with the success. These were seasonal changes, environmental factors, political decisions that affected where people could live, the advent of improved treatments and increase in wealth and improvement of living standards. The same can be said of Italy and much of Europe in the early part of the 20th Century.