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Last week at MalariaWorld: Uganda's trial with MMS to cure malaria

May 16, 2013 - 21:30 -- Bart G.J. Knols

This week one of our subscribers notified MalariaWorld about a YouTube video from Uganda in which the Ugandan Red Cross experiments with MMS (Miracle Mineral Supplement). Take a look at the video here. It is quite amazing to see how this trial was performed, and it appears that the Red Cross of Uganda now claims that they had nothing to do with it...

Is Africa still being used as a play ground for testing dubious drugs on innocent people expecting proper treatment? In 2013? How is it possible that such 'trials' can proceed without the Ugandan health authorities demanding results from Phase 1 and 2 clinical trials? A search on PubMed reveals nothing on MMS as a cure for malaria. Have a look at the video and tell us what you think...

The 'Fake Drugs Kill' campaign is gaining momentum, slowly but surely. After sending out a special email message to all of our subscribers we saw a massive response and thank you for this. If you have signed, we're asking for a few more minutes and request that you use your social media channels and email to contact your network. We need every signature we can get to start tackling this horrible problem of fake drugs. You can help stop the illegal trade that kills innocent people by simply signing a petition. Where? On www.fakedrugskill.orgThis will take less than a minute of your time...

One more week for you to apply for positions with the World Health Organization in Cambodia. One on advocacy and communication, and the other position on monitoring and evaluation. Have a look here to read more about these exciting positions.

Enjoy this week's MalariaWorld - the MW team

Is artemisinic acid a precursor of artemisinin ?

May 4, 2013 - 16:38 -- Pierre Lutgen

Two competing chemotypes.

Already twenty years ago the possibility of two chemotypes for Artemisia annua had been suggested ( HJ Woerdenbag et al., Flavour and Fragrance Journal 8, 1993, 131-137) distinguishing between a Chinese and a Vietnamese chemotype, the former containing 0.17 artemisinin, the latter 1.0%.

D Fulzele et al. ( Phytotherapy Research , 5, 1991, 149-153) found that plants from Europe produced the highest level of artemisin and those from Lucknow produced the highest level of arteannuin-B.

Call for preliminary scientific data for “high risk” project proposals?

May 3, 2013 - 09:30 -- Sombroek HLI

Why not let MalariaWorld play a vital role in supporting ground breaking studies that often lack the preliminary ecological field data, required by traditional funders?
We, as dedicated scientists, can assemble a global bank of preliminary scientific field data for “high risk” project proposals to open new directions within malaria research. In doing so, young scientists are able to test creative ideas ahead of time and more experienced scientists are able to explore unexpected and promising observations or discoveries.

World Malaria Day

April 25, 2013 - 07:08 -- Andre Laas

Today, 25 April marks World Malaria Day.

It is a day to reflect back on the progress that has been made in combating malaria around the globe and to contemplate future directions for research and control efforts to curb the impact and spread of this fully preventable and treatable disease that affects millions of lives on a daily basis. Let’s spare a thought for the countless lives that have been lost to this disease, and for the millions of people whose lives are affected at this very moment. May 2013 see more victories than defeats in the global fight against Malaria!

World Malaria Day: Sign the petition against counterfeit malaria drugs

April 24, 2013 - 21:43 -- Bart G.J. Knols

Today is World Malaria Day, and we are proud to announce the start of the campaign 'Fake Drugs Kill', an initiative of the Dutch Malaria Foundation that also manages the MalariaWorld online platform.

As a malaria professional, you are probably aware of the unfolding tragedy with counterfeit drugs. Either completely fake (drugs containing nothing more than chalk, washing powder, or even brake fluid) or substandard (not containing enough active ingredient) or outdated drugs are flooding the African market on an ever-increasing scale.

Experts like Professors Paul Newton and Nick White have been ringing the alarm bells for years, but in spite of their efforts the problem is getting worse by the day. Read 'Phake', the excellent book on the subject by Roger Bate, and you will appreciate how serious the situation has become...

Guest Editorial: Progress toward malaria elimination: highlighting the need for new strategies

April 24, 2013 - 14:22 -- Bart G.J. Knols

This Guest Editorial was written by Sir Richard Feachem. Dr. Feachem, PhD, DSc(Med) is Director of the Global Health Group at the University of California, San Francisco. From 2002 to 2007, Sir Richard served as founding Executive Director of The Global Fund to Fight AIDS, Tuberculosis and Malaria and Under Secretary General of the United Nations.

Harvard's Jessica Cohen: 'Zanzibar gains could be erased in months'

April 10, 2013 - 20:50 -- Bart G.J. Knols
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Harvard University organised a mini-symposium on malaria on 5 April titled 'Defeating malaria, from the genes to the globe'. It was the first in a series examining global public health problems like malaria. Noteworthy in that regard are the views that were expressed during this symposium regarding the malaria situation on Zanzibar. Assistant Professor Jessica Cohen, who reportedly advised the government of Zanzibar on how to move forward with its fight against malaria made some pretty remarkable statements.

Cohen's predictions showed that malaria on Zanzibar could be eliminated in just 5 years if everyone on the island (more than a million people) would sleep under bednets. Moreover, she noted that if 'only' 65% of the population would use nets, it would take 22 years. The bad news followed: If usage rates drop to 50% she predicted an increase in prevalence to 5% in just 3 months, up from the 2% prevalence now. Worse, if it dropped to just 35%, malaria would strike back and prevalence would rise to 18% in just 3 months.

She concluded that 'these gains can be erased in months'...

Why is WHO opposed to an effective anti-malarial tea ?

April 6, 2013 - 08:14 -- Pierre Lutgen

The following article was published in SLATE Magazine on April 4 by Brendan Borrell. Our association IFBV-BELHERB from Luxembourg is glad to read that some independent voices recognize the merit of Artemisia annua herbal medicine and proud to see that through R&D at their universities Africans will find their own solutions in the fight against tropical diseases. Hereafter excerpts from the paper. The full text is available at www.slate.com/.../wormwood_tea_to_treat_malaria

NEW! Anonymous commenting...

April 5, 2013 - 07:54 -- Bart G.J. Knols

With many thousands of visitors to MalariaWorld each week, we wondered why only few of you ever comment on articles, blogs, forums, etc. After all, we hope that MalariaWorld becomes a '2-way' platform, where we not only provide you with professional information on malaria, but also like to have your input, thoughts, dreams, worries, etc.

Bare-bones genetic control for mosquitoes

April 4, 2013 - 14:43 -- Mark Benedict

It’s a useful reminder to consider what one must have for successful genetic control strains for mosquitoes. While the focus is often on effectors for specific population manipulations, there are other bits “under the hood” that, like an engine, can’t really be ignored. It’s easy to forget how necessary these are when concentrating on something novel. I’ll give you my bare-bones list of basic genetic control features that sooner or later, you simply must have.

New on MalariaWorld: Active member counter

April 3, 2013 - 17:56 -- Serge Christiaans
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A member counter has been placed on MalariaWorld, showing the number of active members who actually log-in to our platform. This is a dynamic counter, which means that every new account will add up immediately. The counter shows on the front page just below the large banners (see screenshot below). On other pages you'll find it just below the blue main menu bar.

If you have any suggestions or  comments please don't hesitate to contact the MalariaWorld Team.
Hope you enjoy it

A conversation with Dr. Bill Jobin: Managing Malaria with Engineering and Public Health interventions

April 1, 2013 - 20:40 -- Sophie Beauvais

Please join us this week, April 1-5, 2013, in a virtual expert panel to discuss current state and future configuration of anti-vector interventions designed to prevent malaria transmission through the suppression of anopheline mosquito vectors.

1950s strategy to control malaria on Zanzibar fails once more

March 29, 2013 - 09:55 -- Bart G.J. Knols

Four years ago, in 2009, I wrote an article for a Dutch newspaper (Bionieuws) with the title 'It is not yet time for a party on Zanzibar'. My article was a response to Tachi Yamada's blog on CNN 'Where have all the malaria patients gone?'. Yamada at that time was touring the spice island together with Ray Chambers and Margret Chan, and for sure their trip must have been pleasant and satisfying. After all, the renewed impetus (largely through the US Presidential Malaria Initiative) in malaria control was starting to pay off. Indoor residual spraying and massive distribution of LLINs yielded a spectacular decline in malaria prevalence. Yamada ends his commentary with a pretty strong statement...

ARTAVOL malaria prophylaxis on BBC

March 27, 2013 - 16:35 -- Pierre Lutgen

Uganda Science Festival . African approaches against tropical diseases.

Listen to Dr Patrick Ogwang on BBC World Service, London Focus on Africa (radio) on Mar 28 3.30-5-30PM

Dear Moussa. Thank you very much for the opportunity to discuss science in Africa. I strongly believe that Africa must set her science agenda if we are to benefit from science. Why? For the following reasons;

Ray Chambers: Saving The Lives Of 4 Million Children In 1,000 Days

March 27, 2013 - 10:52 -- Bart G.J. Knols

In a blog on LinkedIn yesterday, Ray Chambers, the Special Envoy for Malaria to UN Secretary General Ban Ki-moon, sent out a public statement titled 'Saving the lives of 4 million children in 1000 days'. Making reference to the fact that the Millennium Development Goals end by December 2015, Chambers still holds the conviction that we can bring malaria mortality down to zero by the end of 2015. He asserts that the key players to accomplish this are in place, that the solution is simple and not expensive, and that we should do this. It sounds great - and given the comments under his blog ('Inspiring', 'Absolutely will join in an effort to save children', 'Few things could be more important') Chambers will certainly reach the goal of drawing more attention to malaria. Indeed, if you're not familiar with the malaria world, than it simply sounds outrageous that the world has not succeeded in putting every soul under a net in endemic settings, that we have not eliminated malaria in the south just like we did in the north half a Century ago, and that evidence (ca. 1 million deaths averted) over the last decade has clearly shown that we CAN save many lives. But is this realistic?

Last week at MalariaWorld: 2 jobs + 1 event

March 14, 2013 - 21:03 -- Ingeborg van Schayk
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Are you looking for a new job in the field of malaria  or do you know someone who is? then this may interest you: There are 2 vacancies at the ACT consortium: (1) ACT Consortium Technical Communications Officer (closing date 22 March 2013), and (2)  ACT Consortium Policy Liaison Coordinator (closing date 20 March 2013).

PMI sharpens LLIN procurement policy

March 7, 2013 - 15:23 -- Bart G.J. Knols

Concern amongst the malaria community of the inadequacy of current equivalence evaluations for long-lasting insecticidal nets under the WHOPES evaluation scheme has been highlighted in a memo released by USAID/ PMI on 3rd March 2013 entitled “Revised long lasting insecticide treated net (LLIN) procurement specifications for the President’s Malaria Initiative (PMI) program”.
 
The memo states that “After a technical review, PMI has determined that the equivalency status based only on Phase 1 laboratory studies is insufficient to determine eligibility for PMI procurement because these studies do not determine how the LLIN product functions in the field where other factors come into play, particularly physical durability and long-term bioefficacy”.

Look at this before you start to work in the lab today...

March 4, 2013 - 08:25 -- Bart G.J. Knols

This morning I opened the newspaper and read about the breakthrough in science that we now have the complete biochemical 'routemap' of man, us. A few days ago I read an article about rats being capable of training other rats through electrical brain signals. Scientific developments are ongoing at an unprecedented speed - we live in exciting times.

Has America forgotten its heroes?

February 28, 2013 - 20:14 -- Bart G.J. Knols

 

This week I attended the 79th annual meeting of the American Mosquito Control Association (AMCA), which was held in Atlantic City, New Jersey, USA.
 
I was honoured to be invited to give a keynote lecture on the first day of the meeting, with the title 'If Gates gave you 10 million for mosquito research, what would you do with it?'. Steve Mulligan, vice president of the AMCA, in charge of the scientific programme of the meeting asked me to touch on the importance of 'out-of-the-box' science and the need that we have to come forward with radical and transformational new ideas to control vectors of disease.
 
One of my favorite subjects in that regard is to look at the past. Of where the world already eliminated malaria and what we can learn from this. That 800 million people now live in areas where there used to be malaria, but where people now put their kids to bed without having to worry about it anymore. And, may I humbly add to this: It was done without a vaccine…

Durban MIM2013 ready for early registration

February 25, 2013 - 13:12 -- Serge Christiaans
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Early registration

The 'early registration deadline' is July 31th. After this date the regular registration fees apply. Find more information about registration and fees here.

The registration includes a welcome event (Sunday, 6 October 2013), Access to all  conference sessions, Conference documentation, Tea coffee, and lunch. Please note that the registration fee does not include accommodation, airport transfers or any other social events.
 
An online registration form is available here.
 

Photo Contest - Malaria: The BIG Picture

February 17, 2013 - 21:32 -- Bart G.J. Knols

 

Malaria affects the lives of millions across the world. The Swiss Malaria Group* online photo contest seeks to highlight the realities of those living at risk of malaria and the work of those dedicated to changing that reality.
 
The contest is open to all. Send in your photos and captions that tell a story about malaria between 15 February and 24 March via the competition website, where you will find details of the three submission categories. The public will then vote to determine the finalists and a panel of expert judges will select the winners.

Six new ways to control malaria mosquitoes

February 14, 2013 - 07:32 -- Bart G.J. Knols

It is well known that creative thinking is affected by environmental variables. That's why researchers engage in 'off-site' events. Take them out of their comfort zone of the lab or office and miracles may happen.

I am in Pangani, Tanzania, as I write this. Sitting amongst the palm trees overlooking the Indian ocean at Emayani Beach Lodge run by my brother. Thinking back about last week, when we had a kick-off meeting with 14 scientists and entrepreneurs in Ifakara, hosted by the Ifakara Health Institute (IHI). Although this year marks my 20th anniversary of working with IHI, quite a few of us were new to IHI, new to Tanzania, or even new to Africa...

Is PCR genotyping of Plasmodium falciparum a reliable tool for monitoring drug resistance?

February 9, 2013 - 19:15 -- Pierre Lutgen

A recent press release from Wellcome Trust Sanger Institute raised a lot of concern. Based on a scientific paper published in Nature, 13 June 2012, it appears that a single infected person could harbour many genetically different Plasmodium falciparum parasites. The team from Oxford University found that these parasite populations easily swap DNA to create new forms.

This evidently raises the question how far PCR (polymer chain reaction genotyping) can distinguish between recrudescence (or treatment failure) and re-infection by new bites from anopheles mosquitoes.

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