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Gabon

Open Access | Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses

Author(s): 
Sicuri E, Biao P, Hutton G, Tediosi F, Menendez C, Lell B, Kremsner P, Conteh L, Grobusch MP
Reference: 
Malaria Journal 2011, 10:305 (17 October 2011)
Contact email: 
elisa.sicuri@cresib.cat

MalariaWorldMigration implies great challenges in the organization of health interventions that require repeat visits in Gabon.

Open Access | A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon

Author(s): 
Frank M, Lehners N, Mayengue PI, Gabor J, Dal-Bianco M, Kombila DU, Mombo Ngoma G, Supan C, Lell B, Ntoumi F, Grobusch MP, Dietz K, Kremsner PG
Reference: 
Malaria Journal 2011, 10:304 (17 October 2011)

MalariaWorldFour years after the withdrawal of CQ from national treatment guidelines the prevalence of the mutant pfcrt allele remains at 97%.

Open Access | A Randomized Controlled Phase Ib Trial of the Malaria Vaccine Candidate GMZ2 in African Children

Author(s): 
Sabine Bélard, Saadou Issifou, Benjamin Mordmüller, et al.
Reference: 
PLoS ONE 6(7): e22525

Both 30 µg as well as 100 µg intramuscular GMZ2 are immunogenic, well tolerated, and safe in young, malaria-exposed Gabonese children.

Open Access | Assessment of LED fluorescence microscopy for the diagnosis of Plasmodium falciparum infections in Gabon

Author(s): 
Lenz D, Kremsner PG, Lell B, Biallas B, Boettcher M, Mordmuller B, Adegnika AA
Reference: 
Malaria Journal 2011, 10:194 (18 July 2011)
Contact email: 
lenz.dominic@gmail.com

ledFM is a reliable, accurate, fast and inexpensive tool for daily routine malaria diagnosis and may be used as a point of care diagnostic tool.

Open Access | High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

Author(s): 
Ghyslain Mombo-Ngoma, Sunny Oyakhirome, Rosalynn Ord, Julian J Gabor, Katja C Greutelaers, Katharina Profanter, Benedikt Greutelaers, Florian Kurth, Bertrand Lell, Juergen FJ Kun, Saadou Issifou, Cally Roper, Peter G Kremsner, Martin P Grobusch
Reference: 
Malaria Journal 2011, 10:123 (14 May 2011)

There is a high prevalence of dhfr triple mutant with some dhps point mutations in Gabon, in line with treatment failures observed, and molecular markers of SP resistance should be closely monitored.

Open Access | Induction of Plasmodium falciparum-Specific CD4+ T Cells and Memory B Cells in Gabonese Children Vaccinated with RTS,S/AS01E and RTS,S/AS02D

Author(s): 
Selidji T. Agnandji, Rolf Fendel, Benjamin Mordmüller, et al.
Reference: 
PLoS ONE 6(4): e18559
Contact email: 
agnandjis@yahoo.fr

The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies.

In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon

Author(s): 
Jana Held, Shahid A. Soomro, Peter G. Kremsner, F. Herwig Jansen, Benjamin Mordmüller
Reference: 
International Journal of Antimicrobial Agents Volume 37, Issue 5, May 2011, Pages 485-488

Nowadays, artemisinins are the mainstay of malaria treatment, but initial indications of resistance against clinically used derivatives are present.

Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine

Author(s): 
Jean Bernard Lekana-Douki.,Sylvatrie Danne Dinzouna Boutamba., Fousseyni S. Toure-Ndouo., et al.
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 512-517
Contact email: 
Lekana_jb@yahoo.fr

These findings show a substantial benefice of artemether–lumefantrine and artesunate–mefloquine and of new control measures.

Open Access | Prevalence of Plasmodium falciparum infection in asymptomatic rural Gabonese populations

Author(s): 
Nkoghe D, Akue J, Gonzalez J, Leroy EM
Reference: 
Malaria Journal 2011, 10:33 (9 February 2011)
Contact email: 
dnkoghe@hotmail.com

Plasmodium falciparum carriage remains high among adults in rural Gabon. Control measures must be adapted to the region and ecosystem. Routine treatment of asymptomatic individuals should be considered.

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Author(s): 
Jean Bernard Lekana-Douki., Jean Bernard Bongui., Maryvonne Kombila., et al.
Reference: 
Journal of Ethnopharmacology, Volume 133, Issue 3, 16 February 2011, Pages 1103-1108

As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon.

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