Indonesia

We conducted a prospective, inpatient fever study in malaria-endemic Papua, Indonesia to determine non-malaria fever etiologies.

P. vivax-associated coma is rare, occurring 23 times less frequently than that seen with falciparum malaria, and is associated with a high proportion of non-malarial causes and mixed infections using PCR.

Approximately 230 million people live in Indonesia. The country is also home to over 20 anopheline vectors of malaria which transmit all four of the species of Plasmodium that routinely infect humans.

The finding documents the presence of this mutant allele in Indonesia, and implies that selection pressure on the Anopheles population in this area has occurred. Further studies to determine the impact of the resistance allele on the efficacy of pyrethroids in control programmes are needed.

Information on significant malaria vectors associated with specific topography is useful for planning the mosquito control aspect of malaria management.

The new endoperoxyketal polyketides manadoperoxides A−D (2−5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic data and semisynthetic transformations.

The study will provide data on the effect of helminth infections on malaria. It will also give information on anthelminthic treatment efficacy and effectiveness and could help develop
evidence-based policymaking.

Clinical trial of the use of chloroquine for monoinfections of P.falciparum and P. vivax. Although a small study and almost 7 years old, the data provide clear evidence of high grade chloroquine resistance in western Indonesia, a long distance from the known hot spot on the Island of Papua.