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Open Access | Commentary: Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

Submitted by Kabogo on December 29, 2010 - 11:48
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Author(s): 
Sa JM, Twu O
Reference: 
Malaria Journal 2010, 9:374 (23 December 2010)
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Contact email: 
jsa@niaid.nih.gov

The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.

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Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

Submitted by Kabogo on August 18, 2010 - 12:48
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Author(s): 
Khalid Beshir, Colin J. Sutherland, Ioannis Merinopoulos, Naeem Durrani, Toby Leslie, Mark Rowland, and Rachel L. Hallett
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3714-3716, Vol. 54, No. 9
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Contact email: 
Rachel.Hallett@lshtm.ac.uk

Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa.

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