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antigenic variation

The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types

Submitted by Kabogo on March 5, 2010 - 08:59
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Author(s): 
Letusa Albrecht, Catarina Castiñeiras, Bruna O. Carvalho, Simone Ladeia-Andrade, Natal Santos da Silva, Erika H.E. Hoffmann, Rosimeire C. dalla Martha, Fabio T.M. Costa, Gerhard Wunderlich
Reference: 
Gene, Volume 453, Issues 1-2, 15 March 2010, Pages 37-44
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Contact email: 
gwunder@usp.br

The frequently observed mild outcomes of falciparum malaria in many places of the Amazon area prompted us to ask whether a globally restricted variant (var) gene repertoire is present in currently circulating and older isolates of this area.

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Var gene transcription dynamics in Plasmodium falciparum patient isolates

Submitted by Kabogo on February 11, 2010 - 09:06
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Author(s): 
Karin Blomqvist, Johan Normarka, Daniel Nilsson, Ulf Ribacke, Judy Orikiriza, Petter Trillkott, Justus Byarugaba, Thomas G. Egwang, Fred Kironde, Björn Andersson and Mats Wahlgren
Reference: 
Molecular and Biochemical Parasitology, Volume 170, Issue 2, April 2010, Pages 74-83
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Contact email: 
mats.wahlgren@ki.se

The work presented here suggests that trophozoite pRBC is likely to be the optimal source of RNA for predicting the translated var gene species.

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