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Open Access | Glutathione Reductase-null Malaria Parasites Have Normal Blood Stage Growth but Arrest during Development in the Mosquito

Submitted by Kabogo on August 25, 2010 - 08:48
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Author(s): 
Rebecca Pastrana-Mena, Rhoel R. Dinglasan, Adelfa E. Serrano, et al
Reference: 
The Journal of Biological Chemistry, August 27, 2010, 285 27045-27056
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Contact email: 
adelfa.serrano@upr.edu

Malaria parasites contain a complete glutathione (GSH) redox system, and several enzymes of this system are considered potential targets for antimalarial drugs.

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Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

Submitted by patrick sampao on March 31, 2010 - 11:30
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Author(s): 
Joseph T. Bruder, Maureen E. Stefaniak, Noelle B. Patterson, Ping Chen, Svetlana Konovalova, Keith Limbach, Joseph J. Campo, Damodar Ettyreddy, Sheng Li, Filip Dubovsky, Thomas L. Richie, C. Richter King, Carole A. Long, Denise L. Doolan
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3201-3210
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Contact email: 
jbruder@genvec.com

These data highlight the importance of rational vaccine design and support the advancement of adenovector delivery technology for a malaria vaccine.

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Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

Submitted by Inga on March 15, 2010 - 13:55
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Author(s): 
Ahmed S. I. Aly, Megan J. Downie, Choukri Ben Mamoun and Stefan H. I. Kappe
Reference: 
Cellular Microbiology Early View
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Contact email: 
stefan.kappe@sbri.org

The study demonstrates that genetic manipulation provides a platform for the designed, complete attenuation of malaria parasite blood stages and suggests testing the safety and efficacy of P. falciparum NT1 knockout strains in humans.

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