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Open Access | Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

Submitted by Kabogo on July 30, 2010 - 15:17
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Author(s): 
Jorge F.S. Ferreira, Devanand L. Luthria, Tomikazu Sasaki, Arne Heyerick
Reference: 
Molecules 2010, Vol 15 Issue 5, P 3135-3170
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Click here to go to the full article
Contact email: 
Jorge.Ferreira@ars.usda.gov

Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin.Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate.

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

Submitted by Kabogo on April 7, 2010 - 11:00
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Author(s): 
James Chadwick, Michael Jones, Amy E. Mercer, Paul A. Stocks, Stephen A. Ward, B. Kevin Park, Paul M. O’Neill
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 7, 1 April 2010, Pages 2586-2597
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Click here to go to the Journal
Contact email: 
p.m.oneill01@liv.ac.uk

A series of artemisinin–spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared.

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