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Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity

Submitted by Kabogo on July 16, 2010 - 08:20
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Author(s): 
Theola Louie, C. Dean Goodman, Georgina A. Holloway, Geoffrey I. McFadden, Vanessa Mollard, Keith G. Watson
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 15, 1 August 2010, Pages 4611-4613
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Contact email: 
kwatson@wehi.edu.au

A series of dimeric 1,3-cyclohexanedione oxime ethers were synthesized and found to have significant antiplasmodial activity with IC50’s in the range 3–12 μM.

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