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Priority Paper Evaluation: How do malaria parasites activate dendritic cells?

Submitted by Kabogo on August 24, 2010 - 12:15
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Author(s): 
Tracey J Lamb, Michael P Schenk, Stephen M Todryk
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1167-1171
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The authors suggest that parasite DNA complexed with protein is the main trigger for activation of DCs in malaria-infected red blood cells.

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Cellular Immunology and Immune Regulation: Protein–DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

Submitted by Kabogo on April 8, 2010 - 13:14
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Author(s): 
Xianzhu Wu, Nagaraj M. Gowda, Sanjeev Kumar, and D. Channe Gowda
Reference: 
The Journal of Immunology, 2010, Volume 184, Issue 8 Pages 4338 -4348
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Contact email: 
gowda@psu.edu

Dendritic cells (DCs) play a crucial role in the development of protective immunity to malaria. However, it remains unclear how malaria parasites trigger immune responses in DCs.

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