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Genetic diversity of the Plasmodium vivax merozoite surface protein-5 locus from diverse geographic origins

Submitted by Kabogo on April 13, 2010 - 07:13
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Author(s): 
Chaturong Putaporntip, Rachanee Udomsangpetch, Urassaya Pattanawong, Liwang Cui, Somchai Jongwutiwes
Reference: 
Gene, Volume 456, Issues 1-2, 15 May 2010, Pages 24-35
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jongwutiwes@gmail.com

We have conducted a comprehensive analysis of PvMsp-5 by sequencing the entire gene of four parasite populations from northwestern Thailand (n = 73), southern Thailand (n = 53), Indonesia (n = 25) and Brazil (n = 24), and five isolates from other endemic areas. Results reveal that exon I exhibits a significantly higher level of nucleotide diversity at both synonymous and nonsynonymous sites than exon II (p < 0.01).

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Short Communication: Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia

Submitted by Kabogo on March 5, 2010 - 11:07
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Author(s): 
Judy Natalia Jiménez, Georges Snounou, Frank Letourneur, Laurent Rénia, Iván D. Vélez, Carlos E. Muskus
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 67-70
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georges.snounou@upmc.fr

Assessment of the genetic diversity of Plasmodium falciparum in 110 Colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the Andes shared the same Pfmsp1 block 2 MAD20-type allelic variant, despite showing high diversity for other genetical markers.

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Genetic diversity of Plasmodium falciparum in Bolifamba, on the slopes of Mount Cameroon: influence of MSP1 allelic variants on symptomatic malaria and anaemia

Submitted by Inga on February 26, 2010 - 15:43
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Author(s): 
Anong, D.N.; Nkuo-Akenji, T.; Fru-Cho, J.; Amambua-Ngwa, A.; Titanji, V.P.K.
Reference: 
Source: Annals of Tropical Medicine and Parasitology, Volume 104, Number 1, January 2010 , pp. 25-33(9)
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The influence of the genetic diversity of Plasmodium falciparum infection on the clinical presentation of human malaria was investigated in rural Bolifamba, Cameroon.

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Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP)

Submitted by Kabogo on February 26, 2010 - 11:35
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Author(s): 
Aarti Patil, Pamela Orjuela-Sánchez, Mônica da Silva-Nunes, Marcelo U. Ferreira
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 2, March 2010, Pages 298-303
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Contact email: 
muferrei@usp.br

To determine whether rearrangements of repeat motifs during mitotic DNA replication of parasites create significant CSP diversity under conditions of low effective meiotic recombination rates, we examined csp alleles from sympatric P. vivax isolates systematically sampled from an area of low malaria endemicity in Brazil over a period of 14 months.

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