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Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay

Submitted by Kabogo on August 18, 2010 - 13:09
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Author(s): 
Edinson Lucumi, Claire Darling, Doron C. Greenbaum, et al
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3597-3604, Vol. 54, No. 9
Access: 
Click here to go to the Journal
Contact email: 
dorong@upenn.edu

Malaria is a global health problem that causes significant mortality and morbidity, with more than 1 million deaths per year caused by Plasmodium falciparum. Most antimalarial drugs face decreased efficacy due to the emergence of resistant parasites, which necessitates the discovery of new drugs.

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