parasitemia

In this study, we used a benchtop nuclear magnetic resonance (NMR) device to detect hemozoin. This device could be deployed in malaria-endemic settings.

Malaria infection leads to anemia in humans which generally occurs during the chronic phase of the infection.

It is considered that several glycoproteins on erythrocytes in mammalian species are involved in malaria parasite infection.

These results suggest that the quantitative and qualitative changes in the dendritic cell compartment are important for the pathogenesis of ECM.

The rapid, accurate diagnosis of Plasmodium spp. is essential for the effective control of malaria, especially in asymptomatic infections.

Our analysis showed that the capacity of innate responses to restrict initial parasite growth saturates with parasite dose and that experimentally enhanced innate immunity can affect parasite density indirectly via resource depletion.

Drawing on data from mice, they present a new statistical approach to analyzing how parasitemia changes over time and to quantifying and comparing the roles played by the immune system and the availability of red blood cells in regulating parasite numbers.

A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia.

Plasmodium yoelii is an excellent model for studying malaria pathogenesis that is often intractable to investigate using human parasites;

Recombinant Plasmodium falciparum merozoite surface protein 3 (PfMSP3F) and a 24-kDa fragment from its N terminus (MSP3N) that includes the essential conserved domain, which elicits the maximum antibody (Ab)-dependent cellular inhibition (ADCI), were expressed as soluble proteins in Escherichia coli. Both proteins were found to be stable in both soluble and lyophilized forms.