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pathogenesis

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

Author(s): 
J. Brian de Souza, Julius C. R. Hafalla, Eleanor M. Riley and Kevin N. Couper
Reference: 
Parasitology, Volume 137, Issue 05, April 2010, pp 755-772
Contact email: 
kevin.couper@lshtm.ac.uk

Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.

Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment

Author(s): 
Katie R. Hughes, Giancarlo A. Biagini, Alister G. Craig
Reference: 
Molecular and Biochemical Parasitology, Volume 169, Issue 2, February 2010, Pages 71-78
Contact email: 
k.hughes@bio.gla.ac.uk

These findings show that cytoadherence, a potential pathogenic property of P. falciparum infected red blood cells, continues long after the parasite has been killed.

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