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Transcriptomic Profiling of the Saccharomyces cerevisiae Response to Quinine Reveals a Glucose Limitation Response Attributable to Drug-Induced Inhibition of Glucose Uptake

Submitted by patrick sampao on November 18, 2009 - 12:43
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Author(s): 
Sandra C. dos Santos, Sandra Tenreiro, Margarida Palma,Jorg Becker, and Isabel Sá-Correia.
Reference: 
Antimicrobial Agents and Chemotherapy, December 2009, p. 5213-5223, Vol. 53, No. 12, doi:10.1128/AAC.00794-09
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Contact email: 
isacorreia@ist.utl.pt

Quinine has been employed in the treatment of malaria for centuries and is still used against severe Plasmodium falciparum malaria. However, its interactions with the parasite remain poorly understood and subject to debate. In this study, we used the Saccharomyces cerevisiae eukaryotic model to better understand quinine's mode of action and the mechanisms underlying the cell response to the drug.

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