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Comparative Analysis of Stage Specific Gene Regulation of Apicomplexan Parasites: Plasmodium falciparum and Toxoplasma gondii

Submitted by Kabogo on August 10, 2010 - 08:56
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Author(s): 
M. Gopalakrishnan, Anusha; Lopez-Estrano, Carlos
Reference: 
Infectious Disorders - Drug Targets, Volume 10, Number 4, August 2010, pp. 303-311(9)
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Apicomplexans comprise some of the most life threatening parasites infecting human and livestock and includes Plasmodium and Toxoplasma, the causative agents of malaria and toxoplasmosis respectively, in humans as well as Neospora caninum (abortion in livestock, neosporosis in dogs), Cryptosporidium (Diarrheal cryptosporidiosis and opportunistic infections in AIDS patients) and Eimeria (poultry coccidiosis).

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Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma

Submitted by Inga on October 25, 2009 - 15:19
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Author(s): 
G. Guy Bushkin et al.
Reference: 
Eukaryot. Cell. published 16 October 2009, 10.1128/EC.00197-09
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Contact email: 
jsamuels@bu.edu

We conclude that possible selection against N-glycans in protists with apicoplasts occurs by eliminating N-glycans (Theileria), reducing their length (Plasmodium), or by reducing the number of N-glycan sites (Toxoplasma). In addition, occupation of N-glycan sites is markedly reduced in apicoplast proteins versus some secretory proteins in both Plasmodium and Toxoplasma.

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