124-Trioxane

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity

Submitted by Kabogo on March 5, 2010 - 09:01

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Author(s):

Gemma L. Ellis, Richard Amewu, Charlotte Hall, Karen Rimmer, Steven A. Ward, Paul M. O’Neill

Reference:

Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1720-1724

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Contact email:

p.m.oneill01@liv.ac.uk

Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized.

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