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anti-malarial

New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

Author(s): 
Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba, Nobutoshi Murakami
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 5, 1 March 2010, Pages 1520-1523
Contact email: 
murakami@phs.osaka-u.ac.jp

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation.

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

Author(s): 
Devdutt Chaturvedi, Abhishek Goswami, Partha Pratim Saikia, Nabin C. Barua and Paruchuri G. Rao
Reference: 
Chem. Soc. Rev., 2010, 39, 435 - 454

It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

Open Access | IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria

Author(s): 
Piyatida Tangteerawatana, Hedvig Perlmann, Masashi Hayano, Thareerat Kalambaheti, Marita Troye-Blomberg, Srisin Khusmith
Reference: 
Malaria Journal 2009, 8:286 (10 December 2009)
Contact email: 
tmskm@mahidol.ac.th

The results suggest that IL4-590C or T alleles participated differently in the regulation of anti-malarial antibody isotype profiles in primary and secondary malaria infection and, therefore, could play an important role in alteration of malaria severity.

Monitor: A new approach for developing anti-malarial agents

Author(s): 
Michael A. Walker
Reference: 
Drug Discovery Today, Volume 14, Issues 19-20, October 2009, Pages 999-1000 doi:10.1016/j.drudis.2009.06.006
Contact email: 
michael.a.walker@bms.com

No abstract available. 

Bioassay-guided fractionation and in vivo antiplasmodial effect of fractions of chloroform extract of Artemisia maciverae Linn

Author(s): 
A.C. Ene, S.E. Atawodi, D.A. Ameh, G.I. Ndukwe, H.O. Kwanashie
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 288-294,doi:10.1016/j.actatropica.2009.08.016
Contact email: 
atawodi_se@yahoo.com

In the search for new plant-derived anti-malarial compounds, chromatographic fractions of chloroform extract of whole plants of Artemisia maciverae were tested in vivo using chloroquine resistant and chloroquine sensitive Plasmodium berghei NK 65 infected Swiss albino mice.

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