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anti-malarial

Development and Optimization of a Novel 384-Well Anti-Malarial Imaging Assay Validated for High-Throughput Screening

Author(s): 
Sandra Duffy and Vicky M. Avery
Reference: 
Am J Trop Med Hyg 2012 86:84-92
Contact email: 
sandra.duffy@griffith.edu.au

MalariaWorldWe have developed a 384-well, high-throughput imaging assay for the detection of new anti-malarial compounds, which was initially validated by screening a marine natural product library, and subsequently used to screen more than 3 million data points from a variety of compound sources.

Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay

Author(s): 
Rajendran C. Gopalan, Esra Emerce, Colin W. Wright, Bensu Karahalil, Ali E. Karakaya, Diana Anderson
Reference: 
Toxicology Letters, Volume 207, Issue 3, 15 December 2011, Pages 322-325
Contact email: 
D.Anderson1@bradford.ac.uk

MalariaWorldIn the context of antimalarial drug development, the data suggest that all cryptolepine compounds and in particular 2,7-dibromocryptolepine cause DNA damage and therefore may not be suitable for pre clinical development as antimalarial agents.

Open Access | Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation

Author(s): 
David J Sullivan Jr, Nikola Kaludov and Martin N Martinov
Reference: 
Malaria Journal 2011, 10:274
Contact email: 
dsulliva@jhsph.edu

A set of innovative algorithms is used for the fast calculation and interpretation of electron-density attributes of molecular structures at the quantum level for rapid discovery of prospective pharmaceuticals.

Open Access | Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

Author(s): 
Carter N, Pamba A, Duparc S, Waitumbi JN
Reference: 
Malaria Journal 2011, 10:241 (17 August 2011)
Contact email: 
nick.s.carter@gsk.com

Study participants, aged >1 year, with microscopically confirmed uncomplicated Plasmodium falciparum malaria, and haemoglobin 70 g/L or haematocrit 25%, were recruited into two clinical trials conducted in six African countries (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, Mali).

In vitro Anti-Malarial Drug Susceptibility of Temperate Plasmodium vivax from Central China

Author(s): 
Feng Lu,Qi Gao, Kesinee Chotivanich, Hui Xia, Jun Cao, Rachanee Udomsangpetch, Liwang Cui and Jetsumon Sattabongkot
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 2 197-201
Contact email: 
jetsumon@hotmail.com

During 2005–2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique.

Apical Membrane Antigen 1 as an Anti-Malarial Drug Target

Author(s): 
A. MacRaild, Christopher; F. Anders, Robin; Foley, Michael; S. Norton, Raymond
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 16, August 2011 , pp. 2039-2047(9)
Contact email: 
ray.norton@monash.edu

Here we review both the structural details and functional significance of interactions at the hydrophobic cleft of AMA1, and argue that this feature of the protein represents an excellent target for the development of drugs that would block host cell invasion by malarial parasites.

Open Access | Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Author(s): 
Zofou D, Kowa TK, Wabo HK, Ngemenya MN, Tane P, Titanji VP
Reference: 
Malaria Journal 2011, 10:167 (17 June 2011)
Contact email: 
zofden@yahoo.com

These findings justify the use of H. lanceolatum stem bark as anti-malarial by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new drug candidates or phytomedicines for malaria.

Open Access | Quantum dots: a new tool for anti-malarial drug assays

Author(s): 
Min-Je Ku, Fernando M Dossin, Youngseon Choi, Carolina B Moraes, Jiyoung Ryu, Rita Song, Lucio H Freitas-Junior
Reference: 
Malaria Journal 2011, 10:118 (9 May 2011)
Contact email: 
kuminje@ip-korea.org

This new assay can offer a rapid and robust platform to screen novel classes of anti-malarial drugs.

Open Access | In vitro and in vivo assessment of the anti-malarial activity of Caesalpinia pluviosa and analysis of its active fractions

Author(s): 
Ana Carolina AV Kayano, Stefanie CP Lopes, Fernanda G Bueno, Elaine C Cabral, Wanessa CS Neiras, Lucy M Yamauchi, Mary A Foglio, Marcos N Eberlin, Joao Carlos P Mello, Fabio T Costa
Reference: 
Malaria Journal 2011, 10:112 (2 May 2011)
Contact email: 
carolavk@gmail.com

The findings show that the F4 fraction of C. pluviosa exhibits anti-malarial activity in vitro at non-toxic concentrations, which was potentiated in the presence of artesunate.

Review: The State of the Art in Anti-Malarial Drug Discovery and Development

Author(s): 
N. Burrows, Jeremy; Chibale, Kelly; N.C. Wells, Timothy
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 10, May 2011 , pp. 1226-1254(29)
Contact email: 
burrowsj@mmv.org

This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches being developed as a contribution towards the malaria eradication agenda.

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