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Defining the Role of Mutations in Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Gene Using an Episomal Plasmodium falciparum Transfection System

Submitted by Kabogo on August 18, 2010 - 13:05
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Author(s): 
Alyson M. Auliff, John H. Adams, Michael T. O'Neil, and Qin Cheng
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3927-3932, Vol. 54, No. 9
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Contact email: 
qin.cheng@defence.gov.au

Plasmodium vivax resistance to antifolates is prevalent throughout Australasia and is caused by point mutations within the parasite dihydrofolate reductase (DHFR)-thymidylate synthase. Several unique mutations have been reported in P. vivax DHFR, and their roles in resistance to classic and novel antifolates are not entirely clear due, in part, to the inability to culture P. vivax in vitro.

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Open Access | Plasmodium falciparum spermdine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

Submitted by patrick sampao on April 14, 2010 - 13:29
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Author(s): 
John VW B., Linda ., et al.
Reference: 
BMC Genomics 2010, Vol 11:235
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Contact email: 
jbecker@csir.co.za

This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. 

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