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Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes

Submitted by Kabogo on February 13, 2010 - 11:49
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Author(s): 
Himanshu Atheaya, Shabana I. Khan, Ritu Mamgain and Diwan S. Rawat
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 4, 15 February 2008, Pages 1446-1449
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dsrawat@chemistry.du.ac.in

Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H2O2/TFE in presence of MeReO3 as a catalyst.

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Brief report: HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro

Submitted by Inga on January 14, 2010 - 11:06
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Author(s): 
Lokesh C. Mishra, Amit Bhattacharya, Manish Sharma, AND Virendra K. Bhasin
Reference: 
Am J Trop Med Hyg 2010;82 148-150
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virendrabhasin@hotmail.com

Most malaria endemic regions are co-infested with HIV infection. 

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Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

Submitted by Inga on December 7, 2009 - 11:51
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Author(s): 
Pedro A. Moura, John B. Dame, and David A. Fidock
Reference: 
Antimicrob. Agents Chemother. 2009;53 4968-4978
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df2260@columbia.edu

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites.

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