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antimalarial drug

Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain

Author(s): 
Denis Zofou, Mathieu Tene, Pierre Tane & Vincent P. K. Titanji
Reference: 
Parasitology Research, Volume 110, Number 2, 539-544,
Contact email: 
zofden@yahoo.com

MalariaWorldFor decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation.

Open Access | Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications

Author(s): 
Mubjer RA, Adeel AA, Chance ML, Hassan AA
Reference: 
Malaria Journal 2011, 10:245 (21 August 2011)
Contact email: 
reemmubjer@yahoo.co.uk

This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen.

Open Access | Resistance-mediating polymorphisms of Plasmodium falciparum among isolates from children with severe malaria in kumasi, ghana

Author(s): 
Abruquah H, Bio F, Tay S, Lawson B.
Reference: 
Ghana Medical Journal, Volume 44, Number 2
Contact email: 
bioy97@yahoo.co.uk

The study affirms Pfcrt as a better chloroquine resistance marker.

In Vivo and In Vitro Efficacy of Chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia

Author(s): 
H. Siswantoro, B. Russell, A. Ratcliff, B. Prasetyorini, F. Chalfein, J. Marfurt, E. Kenangalem, M. Wuwung, K. A. Piera, E. P. Ebsworth, N. M. Anstey, E. Tjitra, and R. N. Price
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 197-202, Vol. 55, No. 1
Contact email: 
rprice@menzies.edu.au

Reports of potential drug-resistant strains of Plasmodium malariae in western Indonesia raise concerns that chloroquine resistance may be emerging in P. malariae and P. ovale.

Imported Malaria in Finland 1995 to 2008: An Overview of Surveillance, Travel Trends, and Antimalarial Drug Sales (pages 400–404)

Author(s): 
Sandra Guedes, Heli Siikamki, Anu Kantele and Outi Lyytikinen
Reference: 
Journal of Travel Medicine, Volume 17, Issue 6, pages 400–404, November/December 2010
Contact email: 
guedesandra@gmail.com

More efforts should be focused on disseminating pre-travel advice to immigrants planning to visit friends and relatives and travelers on self-organized trips.

Open Access | Identification and Characterization of a Liver Stage-Specific Promoter Region of the Malaria Parasite Plasmodium

Author(s): 
Susanne Helm, Christine Lehmann, Andreas Nagel, Rebecca R. Stanway, Sebastian Horstmann, Manuel Llinas, Volker T. Heussler
Reference: 
PLoS ONE 5(10): e13653
Contact email: 
heussler@bni-hamburg.de

During the blood meal of a Plasmodium-infected mosquito, 10 to 100 parasites are inoculated into the skin and a proportion of these migrate via the bloodstream to the liver where they infect hepatocytes.

Letter: Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin

Author(s): 
Hélène Savini, Jean Baptiste Souraud, Sébastien Briolant, Eric Baret, Rémy Amalvict, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 966-967, Vol. 54, No. 2

No abstract available

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

Author(s): 
Ian A. Graham, Katrin Besser, Dianna Bowles et al.
Reference: 
Science 15 January 2010: Vol. 327. no. 5963, pp. 328 - 331
Contact email: 
iag1@york.ac.uk

Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding.

Open Access | Communication: Synthesis and Evaluation of Hybrid Bis-cationic Salts as Antimalarial Drugs

Author(s): 
Stéphanie Ortial, Séverine Denoyelle, Sharon Wein, Olivier Berger, Thierry Durand, Roger Escale, Alain Pellet, Henri Vial, Yen Vo-Hoang
Reference: 
ChemMedChem : Volume 5, Issue 1, Date: January 4, 2010, Pages: 52-55

Resistance is futile: A new series of hybrid bis-cations has been synthesized as potent antimalarial agents.

Research Highlight : Antimalarial drugs : Ozonides to the rescue

Author(s): 
Richard White
Reference: 
Nature Chemistry (4 December 2009)

No Abstract Available

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