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antimalarial reversed chloroquine

Synthesis, Structure-Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

Submitted by Kabogo on August 10, 2010 - 08:20
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Author(s): 
SJ Burgess, JX Kelly, S Shomloo, S Wittlin, R Brun, K Liebmann, DH Peyton
Reference: 
J. Med. Chem. August 4, 2010
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Contact email: 
peytond@pdx.edu

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum

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