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Open Access | In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Submitted by Kabogo on October 13, 2011 - 07:26
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Author(s): 
Becker JV, van der Merwe MM, Van Brummelen AC, Pillay P, Crampton BG, Mmutlane EM, Parkinson C, van Heerden FR, Crouch NR, Smith PJ, Mancama DT, Maharaj VJ
Reference: 
Malaria Journal 2011, 10:295 (11 October 2011)
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jbecker@csir.co.za

MalariaWorldThe novel mode of action of dehydrobrachylaenolide, detected during these studies, will play an ongoing role in advancing anti- plasmodial drug discovery efforts.

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Seaweeds as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India

Submitted by Kabogo on June 23, 2011 - 06:51
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Author(s): 
Sundaram Ravikumar, Samuel Jacob Inbaneson and Palavesam Suganthi
Reference: 
Parasitology Research, Volume 109, Number 1, 47-52
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Contact email: 
Ravibiotech201321@gmail.com

The problems of resistant lines of Plasmodium falciparum are escalating.

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Modulation of cerebral malaria by fasudil and other immune-modifying compounds

Submitted by Kabogo on April 22, 2010 - 12:06
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Author(s): 
Judith H. Waknine-Grinberg, James A. McQuillan, Nicholas Hunt, Hagai Ginsburg, Jacob Golenser
Reference: 
Experimental Parasitology, Volume 125, Issue 2, June 2010, Pages 141-146
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Contact email: 
golenser@md.huji.ac.il

Malaria continues to cause millions of deaths annually. No specific effective treatment has yet been found for cerebral malaria, one of the most severe complications of the disease.

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