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Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene

Submitted by patrick sampao on June 10, 2010 - 12:48
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Author(s): 
Nathalie W., Sébastien B., et al.
Reference: 
J. Antimicrob. Chemother., July 2010; 65: 1387 - 1394.
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bruno.pradines@free.fr

The aim of the study was to assess the in vitro potentiating effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in combination with mefloquine, chloroquine or monodesethylamodiaquine against Plasmodium falciparum and to evaluate whether the effects of atorvastatin could be associated with mutations or gene copy number in multidrug resistance (MDR)-like protein genes.

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Open Access | Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum

Submitted by patrick sampao on May 27, 2010 - 11:29
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Author(s): 
Parquet V, Henry M, Wurtz N, Dormoi J, Briolant S, Gil M, Baret E, Amalvict R, Rogier C, Pradines B
Reference: 
Malaria Journal 2010, 9:139 (25 May 2010)
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verogofio@hotmail.com

Genotypes and gene copy number were assessed for pfcrt, pfmdr1, pfmdr2, pfmrp genes. In addition, the number of DNNND, DDNHNDNHNN repeats in pfnhe-1 ms4760 and the ms4760 profile were determined for each strains of P. falciparum.

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Letter: Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin

Submitted by Kabogo on January 28, 2010 - 12:17
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Author(s): 
Hélène Savini, Jean Baptiste Souraud, Sébastien Briolant, Eric Baret, Rémy Amalvict, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 966-967, Vol. 54, No. 2
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No abstract available

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