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Open Access | Editorial: How Do We Best Diagnose Malaria in Africa?

Author(s): 
Philip J. Rosenthal
Reference: 
Am J Trop Med Hyg 2012 86:192-193
Contact email: 
prosenthal@medsfgh.ucsf.edu

MalariaWorldIn this regard, the advent of rapid diagnostic tests (RDTs) for malaria is an important advance. Multiple immunochromatographic tests, incorporating a number of different parasite antigens and produced by many different manufacturers, are now available.

Open Access | Diversity of Plasmodium falciparum Chloroquine Resistance Transporter (pfcrt) Exon 2 Haplotypes in the Pacific from 1959 to 1979

Author(s): 
Chim W. Chan, Rita Spathis, Dana M. Reiff, Stacy E. McGrath, Ralph M. Garruto, J. Koji Lum
Reference: 
PLoS ONE 7(1): e30213
Contact email: 
aramidus44@gmail.com

MalariaWorldNearly one million deaths are attributed to malaria every year.

Open Access | Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure

Author(s): 
Mallick PK, Joshi H, Valecha N, Sharma SK, Eapen A, Bhatt RM, Srivastava HC, Sutton PL, Dash AP, Bhasin VK
Reference: 
Malaria Journal 2012, 11:16 (11 January 2012)
Contact email: 
pkmmrc@gmail.com

MalariaWorldThe wild type pfcrt gene is linked to chloroquine sensitivity; however, presence of mutation cannot explain the therapeutic efficacy of CQ in the current scenario of chloroquine resistance.

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

Author(s): 
Eugénie Aimée Madiesse Kemgne, Wilfred Fon Mbacham, Fabrice Fekam Boyom, Paul Henri Amvam Zollo, Etienne Tsamo & Philip J. Rosenthal
Reference: 
Parasitology Research, Volume 110, Number 1, 109-117

MalariaWorldAnnonaceae species, Uvariopsis congolana (leaf, stem), Polyalthia oliveri (stem bark), and Enantia chlorantha (stem, stem bark) with yields ranging from 0.33% to 4.60%.

Open Access | Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum

Author(s): 
Poyomtip T, Suwandittakul N, Sitthichot N, Khositnithikul R, Tan-ariya P, Mungthin M
Reference: 
Malaria Journal 2012, 11:7 (5 January 2012)
Contact email: 
teera_075@hotmail.com

MalariaWorldData from the present study put doubt regarding the pfnhe-1 gene as to whether it could be used as the suitable marker for QN resistance in Thailand.

Open Access | Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America

Author(s): 
Jovel IT, Mejia RE, Banegas E, Piedade R, Alger J, Fontecha G, Ferrreira PE, Veiga MI, Enamorado IG, Bjorkman A, Ursing J
Reference: 
Malaria Journal 2011, 10:376 (19 December 2011)
Contact email: 
irina.jovel@ki.se

MalariaWorldThe results indicate that P. falciparum from Honduras remain sensitive to chloroquine and sulphadoxine-pyrimethamine.

Open Access | Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites

Author(s): 
Ploemen I, Behet M, Nganou-Makamdop K, van Gemert G, Bijker E, Hermsen C, Sauerwein R
Reference: 
Malaria Journal 2011, 10:350 (9 December 2011)
Contact email: 
I.ploemen@ncmls.ru.nl

MalariaWorldPbGFP-Luccon parasites are a straightforward and valuable tool for comprehension of the biological and immunological principles underlying protection against malaria.

Inhibitory Activity of Ferroquine, versus Chloroquine, against Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I In Vitro Assay.

Author(s): 
Eyase FL, Akala HM, Johnson JD, Walsh DS.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):984-8.
Contact email: 
douglas.walsh@afrims.org

MalariaWorldThese findings support the notion that FQ could be useful in treating persons with P. falciparum malaria.

Open Access | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

Author(s): 
Ouattara A, Doumbo S, Saye R, Beavogui AH, Traore B, Djimde A, Niangly A, Kayentao K, Diallo M, Doumbo OK, Thera MA
Reference: 
Malaria Journal 2011, 10:345 (24 November 2011)
Contact email: 
amed@icermali.org

MalariaWorldOptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics.

Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections

Author(s): 
Cátia Ramalhete, Filipa P. da Cruz, Dinora Lopes, Silva Mulhovo, Virgílio E. Rosário, Miguel Prudêncio, Maria-José U. Ferreira
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 24, 15 December 2011, Pages 7474-7481
Contact email: 
mjuferreira@ff.ul.pt

MalariaWorldBioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-d-glucopyranoside (3) and kuguaglycoside A (4).

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