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hypoxanthine-guanine

Short Communication: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

Submitted by patrick sampao on July 19, 2010 - 10:31
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Author(s): 
Dianne T., Dana H., et al.
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 165-169
Access: 
Click here to go to the Journal
Contact email: 
luke.guddat@uq.edu.au

We have purified the recombinant Pv 6-oxopurine (PRTase) and compared its properties with the human and Pf enzymes. The Pv enzyme uses hypoxanthine and guanine with similar catalytic efficiency to the Pf enzyme but xanthine is not a substrate, hence we identify this enzyme as PvHGPRT.

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