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intermittent preventive treatment

Open Access | Malaria Prevention with IPTp during Pregnancy Reduces Neonatal Mortality

Submitted by Inga on March 12, 2010 - 15:32
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Author(s): 
Clara Menéndez, Azucena Bardají, Betuel Sigauque, Sergi Sanz, John J. Aponte, Samuel Mabunda, Pedro L. Alonso
Reference: 
PLoS ONE 5(2): e9438
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Contact email: 
menendez@clinic.ub.es

In the global context of a reduction of under-five mortality, neonatal mortality is an increasingly relevant component of this mortality. Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association.

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Open Access | Duration of Protection Against Clinical Malaria Provided by Three Regimens of Intermittent Preventive Treatment in Tanzanian Infants

Submitted by Inga on March 12, 2010 - 14:58
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Author(s): 
Matthew Cairns, Roly Gosling, Ilona Carneiro, Samwel Gesase, Jacklin F. Mosha, Ramadhan Hashim, Harparkash Kaur, Martha Lemnge, Frank W. Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(3): e9467
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Contact email: 
matthew.cairns@lshtm.ac.uk

Intermittent preventive treatment in infants (IPTi) is a new malaria control tool. This study investigated how protection against malaria given by SP, chlorproguanil-dapsone (CD) and mefloquine (MQ), varied with time since administration of IPTi.

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Commentary: Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?

Submitted by Inga on February 5, 2010 - 16:41
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Author(s): 
S Parikh and P J Rosenthal
Reference: 
Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162
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sparikh@medsfgh.ucsf.edu

We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.

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Open Access | Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control

Submitted by Inga on December 23, 2009 - 10:41
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Author(s): 
Collins K Ahorlu, Kwadwo A Koram, Atsu K Seakey, Mitchell G Weiss
Reference: 
Malaria Journal 2009, 8:292 (11 December 2009)
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Contact email: 
cahorlu@noguchi.mimcom.org

This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness in the home in reducing the parasite prevalence and malaria morbidity in young children in a coastal village in Ghana.

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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial

Submitted by Inga on November 27, 2009 - 14:30
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Author(s): 
Roly Gosling , Samwel Gesase, Jacklin Mosha, Ilona Carneiro, Ramadhan Hashim, Martha Lemnge, Frank Mosha , Brian Greenwood, Daniel Chandramohan
Reference: 
The Lancet, Volume 374, Issue 9700, Pages 1521 - 1532, 31 October 2009, doi:10.1016/S0140-6736(09)60997-1
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Contact email: 
Roly.Gosling@gmail.com

Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.

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Society Meeting Paper: Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants

Submitted by Kabogo on November 26, 2009 - 07:26
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Author(s): 
Matthew Cairns, Roly Gosling, Samwel Gesase, Jacklin Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1199-1201, doi:10.1016/j.trstmh.2009.06.007
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Contact email: 
matthew.cairns@lshtm.ac.uk

Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective drug for IPTi.

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Intermittent preventive treatment of malaria in pregnancy (IPTp): participation of community-directed distributors of ivermectin for onchocerciasis improves IPTp access in Ugandan rural communities

Submitted by Kabogo on November 26, 2009 - 06:58
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Author(s): 
Richard Ndyomugyenyi, Ephraim Tukesiga, James Katamanywa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1221-1228, doi:10.1016/j.trstmh.2009.03.006
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Contact email: 
richardndyomugyenyi@yahoo.com

Access and compliance to sulfadoxine–pyrimethamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) when delivered by community-directed drug distributors (CDDs) of ivermectin for onchocerciasis control (intervention arm) and through delivery of SP–IPTp during antenatal care visit (control arm) was investigated in western Uganda.

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Comment: Intermittent preventive treatment of malaria in infancy

Submitted by Inga on November 13, 2009 - 10:40
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Author(s): 
Rose McGready
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1478-1480
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Open access
Contact email: 
rose@shoklo-unit.com

Looking to the future, and hoping that current downward trends in malaria are sustained, we need to evaluate the newly introduced antimalarials (piperaquine and pyronaridine look promising12) as well as mefloquine to assess whether and when is the best time to give IPT.

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Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

Submitted by Inga on November 13, 2009 - 10:24
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Author(s): 
John J Aponte et al.
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1533-1542
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Contact email: 
marcel.tanner@unibas.ch

Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.

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