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Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

Submitted by Kabogo on February 25, 2010 - 21:35
Tags:
Author(s): 
Matthias A. Fügi, Sergio Wittlin, Yuxiang Dong, and Jonathan L. Vennerstrom
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1042-1046, Volume 54, No. 3
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Contact email: 
jvenners@unmc.edu

Using combination experiments with cultured Plasmodium falciparum cells, we investigated the interactions of the nitroxide radical spin trap, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), and four of its analogs with artemisinin and the ozonide drug development candidate OZ277.

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