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Mechanisms of Resistance: Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

Submitted by Kabogo on June 18, 2010 - 09:38
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Author(s): 
Benoit Witkowski, Marie-Laure Nicolau, Patrice Njomnang Soh, Xavier Iriart, Sandie Menard, Muriel Alvarez, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, and Antoine Berry
Reference: 
Antimicrobial Agents and Chemotherapy, July 2010, p. 3049-3051, Vol. 54, No. 7
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Contact email: 
berry.a@chu-toulouse.fr

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins.

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