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Pvs25

Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine

Submitted by patrick sampao on March 9, 2011 - 08:38
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Author(s): 
Takeshi Miyata., Tetsuya Harakuni., Takeshi Arakawa., et al.
Reference: 
Vaccine, Volume 29, Issue 15, 24 March 2011, Pages 2720-2726
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Contact email: 
tarakawa@comb.u-ryukyu.ac.jp

This study, the first preclinical evaluation of adenovirus-vectored malaria OSPs, implicates a potential inclusion of malaria transmission-blocking vaccine antigens in viral vector systems.

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Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission

Submitted by patrick sampao on August 11, 2010 - 13:30
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Author(s): 
Andrew M. Blagborough, Shigeto Yoshida, Jetsumon Sattabongkot, Takafumi Tsuboi, Robert E. Sinden
Reference: 
Vaccine, Volume 28, Issue 37, 23 August 2010, Pages 6014-6020
Access: 
Click here to go to the Journal
Contact email: 
andrew.blagborough@imperial.ac.uk

This study offers a novel tool for the development of malarial transmission-blocking vaccines against the sexual stages of the parasite, using the Baculovirus Dual Expression System that functions as both a subunit, and DNA based vaccine.

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