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Host Response and Inflammation: Neutralization of Malaria Glycosylphosphatidylinositol In Vitro by Serum IgG from Malaria-Exposed Individuals

Submitted by patrick sampao on August 18, 2010 - 14:28
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Author(s): 
Brian de Souza J., Manohursingh R., et al
Reference: 
Infect. Immun., Sep 2010; 78: 3920 - 3929.
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Contact email: 
Brian.deSouza@lshtm.ac.uk

In conclusion, we have established an in vitro assay to test the toxin-neutralizing activities of antimalarial antibodies and have shown that anti-GPI antibodies from malaria-immune individuals are able to neutralize GPI-induced macrophage activation; however, the clinical relevance of anti-GPI antibodies remains to be proven, given that malarial schizonts contain other proinflammatory moieties, in addition to GPI.

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