• 5999 malaria professionals are enjoying the free benefits of MalariaWorld today
Home › sulfadoxine-pyrimethamine

sulfadoxine-pyrimethamine

Five Years of Large-Scale dhfr and dhps Mutation Surveillance Following the Phased Implementation of Artesunate Plus Sulfadoxine-Pyrimethamine in Maputo Province, Southern Mozambique

Submitted by patrick sampao on May 4, 2010 - 14:10
Tags:
Author(s): 
Jaishree Raman, Francesca Little, Cally Roper, Immo Kleinschmidt, Yasmin Cassam, Rajendra Maharaj, and Karen I. Barnes
Reference: 
Am J Trop Med Hyg, May 2010; 82: 788 - 794.
Access: 
Click here to go to the Journal
Contact email: 
jaishree.raman@mrc.ac.za

The high "quintuple" mutation prevalence suggests a limited useful therapeutic lifespan of AS-SP for treating uncomplicated malaria, and may curb efficacy of SP-monotherapy for intermittent preventive treatment in Mozambique.

_____________________________________________________________

Commentary: Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?

Submitted by Inga on February 5, 2010 - 16:41
Tags:
Author(s): 
S Parikh and P J Rosenthal
Reference: 
Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162
Access: 
Click here to go to the journal
Contact email: 
sparikh@medsfgh.ucsf.edu

We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.

_____________________________________________________________

The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum.

Submitted by Kabogo on November 18, 2009 - 12:38
Tags:
Author(s): 
Ananias A. Escalante, David L. Smith, Yuseob Kim.
Reference: 
Trends in Parasitology, Volume 25, Issue 12, December 2009, Pages 557-563, doi:10.1016/j.pt.2009.09.008
Access: 
Restricted
Contact email: 
Ananias.Escalante@asu.edu

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat.

_____________________________________________________________

Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

Submitted by Inga on November 13, 2009 - 10:24
Tags:
Author(s): 
John J Aponte et al.
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1533-1542
Access: 
Restricted
Contact email: 
marcel.tanner@unibas.ch

Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.

_____________________________________________________________
Syndicate content