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Open Access | Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

Submitted by Kabogo on June 4, 2010 - 07:58
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Author(s): 
Selina E. R. Bopp, Vandana Ramachandran, Kerstin Henson, Angelina Luzader, Merle Lindstrom, Muriel Spooner, Brian M. Steffy, Oscar Suzuki, Chris Janse, Andrew P. Waters, Yingyao Zhou, Tim Wiltshire, Elizabeth A. Winzeler
Reference: 
PLoS ONE 5(5): e10903.
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Click here to go to the full article
Contact email: 
selina@scripps.edu

The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection.

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Investigation of reproductive toxicity of piperaquine in mice

Submitted by Kabogo on March 26, 2010 - 16:48
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Author(s): 
Kevin T. Batty, Brioni R. Moore, Verity Stirling, Kenneth F. Ilett, Madhu Page-Sharp, Keith B. Shilkin, Ivo Mueller, Stephen J. Rogerson, Harin A. Karunajeewa, Timothy M.E. Davis
Reference: 
Reproductive Toxicology, Volume 29, Issue 2, April 2010, Pages 206-213
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Contact email: 
Kevin.Batty@curtin.edu.au

Although we found no significant PQ toxicity, clinical data are lacking and monitoring of women and their infants for biochemical and haematological adverse effects is recommended when PQ is used in pregnancy.

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