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Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

Submitted by patrick sampao on April 19, 2010 - 14:17
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Author(s): 
Marjorie M., Rita T., et al.
Reference: 
Infection and Immunity, Vol. 78, No. 5 p. 2182-2188, May 2010
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Contact email: 
renia_laurent@immunol.a-star.edu.sg

Here, we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-CQ protocol.

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