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balancing selection

Open Access | Loss of balancing selection in the beta S globin locus

Submitted by Inga on February 7, 2010 - 14:10
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Author(s): 
Niven A Salih, Ayman A Hussain, Ibrahim A Elmugtaba, Abeir M Elzein, Ibrahim M Elhassan, Eltahir AG Khalil, Hani B Ishag, Hiba S Mohamed, Dominic Kwiatkowski and Muntaser E Ibrahim
Reference: 
BMC Medical Genetics 2010, 11:21
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Contact email: 
mibrahim@iend.org

Probably the best example of the rise and maintenance of balancing selection as an evolutionary trend is the role of S-haemoglobin (HbS - rs334) in protecting from malaria. Yet, the dynamics of such a process remains poorly understood, particularly in relation to different malaria transmission rates and the genetic background of the affected populations.

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The action of falciparum malaria on the human and chimpanzee genomes compared: Absence of evidence for a genomic signature of malaria at HBB and G6PD in three subspecies of chimpanzee

Submitted by patrick sampao on November 26, 2009 - 06:45
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Author(s): 
T.S. MacFie, E. Nerrienet, R.E. Bontrop, N.I. Mundy
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1248-1252, doi:10.1016/j.meegid.2009.06.025
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Contact email: 
nim21@cam.ac.uk

Here we investigate whether the genomic signatures of plasmodial infection found in humans are also present in chimpanzees.

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