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Modeling of hemodynamics arising from malaria infection

Submitted by Inga on February 27, 2010 - 09:52
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Author(s): 
Yohsuke Imai, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi
Reference: 
Journal of Biomechanics, In Press, Corrected Proof, Available online 21 February 2010
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Contact email: 
yimai@pfsl.mech.tohoku.ac.jp

We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles.

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The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum.

Submitted by Kabogo on November 18, 2009 - 12:38
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Author(s): 
Ananias A. Escalante, David L. Smith, Yuseob Kim.
Reference: 
Trends in Parasitology, Volume 25, Issue 12, December 2009, Pages 557-563, doi:10.1016/j.pt.2009.09.008
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Contact email: 
Ananias.Escalante@asu.edu

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat.

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Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

Submitted by Inga on November 10, 2009 - 20:48
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Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746
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Contact email: 
sherrera@inmuno.org

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.
 

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