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murine model

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

Author(s): 
J. Brian de Souza, Julius C. R. Hafalla, Eleanor M. Riley and Kevin N. Couper
Reference: 
Parasitology, Volume 137, Issue 05, April 2010, pp 755-772
Contact email: 
kevin.couper@lshtm.ac.uk

Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.

Open Access | Algorithms to predict cerebral malaria in murine models using the SHIRPA protocol

Author(s): 
Yuri C Martins, Guilherme L Werneck, Leonardo JM Carvalho, Beatriz PT Silva, Bruno G Andrade, Tadeu M Souza, Diogo O Souza, Claudio T Daniel-Ribeiro
Reference: 
Malaria Journal 2010, 9:85 (24 March 2010)
Contact email: 
yuri@ioc.fiocruz.br

These algorithms work with data from a simple, inexpensive, reproducible and fast protocol. Most importantly, they can predict CM development very early, estimate time of death, and might be a valuable tool for research using CM murine models.

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