Reply to: Injectable artesunate: cure or killer?
Further to the memberblog of Irene Teis, June 27, 2014 "Injectable artesunate, cure or killer" where several cases of haemolytic anemia are describeb in Belgium, Netherlands, Japan, Germany a paper published in Malaria Journal (2014, Oct 11:13) describes a similar case in France. An Ivoirian female developed severe haemolytic anemia after treatment with parenteral artesunate. Further investigations evidenced drug-induced antibodies related to artesunate. It was concluded a drug-mediated autoimmune haemolytic anemia.
Reply to: Column: Malaria in Shakespeare’s land
In the 2nd world war era, locally transmitted vivax malaria was a problem even past the arctic circle, and certainly in Norway and Finland. The north dutch endemicity is mentioned by the comment.
Reply to: Brief histories of two contrasting strategies in the fight against malaria
While I think that characterizing the environmental approach as being ‘holistic’ is a bit exaggerated, I think Jobin’s observation that this stage preceded the specialist approach where malaria was controlled and is still being controlled in more developed countries is very useful. The link between malaria control and environmental sanitation, which on paper was present in the early years of WHO, never materialized, not only because the malariologists associated with the specialist approach expressed little interest in it but also because the environmentalists who should have been pushing the environmental approach to malaria control were largely ignorant of the long history of success with efforts that focused on controlling malaria carrying vectors.
I think that by promoting the environmental approach to precede that of the specialist approach makes not only good economic sense but it reduces the current tension between these two approaches. They should not be seen to be in opposition but complementary in a temporal sense – environment first, special control efforts to follow as soon as the first approach begins to demonstrate results.
Reply to: Another interesting case
I am a medical student aanelief that the maternity doctor/ (obs/gyn) should treat the woman because he is the most qualified to determine and help prevent a miscarriage and stillbirth. Based on the fact that gametocytes are present, merozoites may also be lurking so I would take blood samples to hopefully give give her a clear bill of health.
Reply to: Indoor residual spraying with microencapsulated DEET repellent (N, N-diethyl-m-toluamide) for control of Anopheles arabiensis and Culex quinquefasciatus
Attached paper opens the door for a new approach. For years pyrethroid was the only pesticide allowed by WHO for the impregnation of bednets. Initially we were made to believe it was a natural produce derived from flowers, but it is indeed a mass produced chemical. Pyrthroid resistance has shown up very early and nowadays leeds to the catastrophic failure of ITNs and LLINs (see attached PPT). As WHO opened the door for other impregnants for bednets in 2013 (WHO/HTM/NTD/WHOPES/2013.6) several trials have already been run with other insecticides, but all based on industrial products from the North. A perpetuation of colonialism. Africans should jump into this open door because there are many local plants which people use as repellents and insecticides. The number of peer reviewed papers on this topic is overwhelming. At this stage it is sufficient to quote Azadiracta indica, Cymbopogon citratus, Artemisia afra, Ocimum canum, Melia azaderach. It would render Africa independant from the massive import of pesticides and repellents from the North.