Reply to: Lessons from the successful national malaria campaign of Italy 1900-1962
Dear Dr Giancarlo,
You are correct. There was no miracle. (And Mussolini should not be given credit for any inspired thoughts on his part in the battle against malaria.) Italy in the 1920s was considered a centre for malaria research, and yet in 1924, the League of Nations Malaria Commission reported it still couldn't suggest 'any single plan for dealing with malaria which would certainly be permanently effective in actual practice'. But the Commission reported a year later, in 1925, after inspecting the antimalaria works in Palestine that others should follow the methods used there, and the people involved in Palestine with the antimalaria work were benefactors of the world (not just of the Palestine population). The result was that almost only Palestine/Israel (apart from North America and Europe) is shown as the only place in the world by 1970 as having eliminated malaria. The unique contribution made by Dr Kligler in 1922 in Palestine had been his emphasis on education. He stressed education was as important as destruction of the mosquito breeding sites (which breeding site destruction methods were different in every case according to the locality).
This emphasis on education is exportable for the benefit of malaria control in Africa, and Bill Jobin is correct to point out that several decades will be needed before real progress is achieved. But perhaps that is why the malaria professionals are too impatient in their search for the magic bullet, the quick fix, to realise or overlook the role that education plays in malaria elimination.
Reply to: Loop-Mediated Isothermal Amplification Method (LAMP): Low and Effective cost Novel Tool for Molecular Public Health
I have had trouble with negative control (no template)for a few month like others, at first was all OK with LAMP, but suddenly it wasn't work.
I have changed primer stock, betaine, dntp's, MgSO4, buffer, water (I use DNAse free). The mix is made in a different room to that I add the templated (with different pipet, too) I use filter tips.
To probe if I had primers contamination, I did a PCR with: just B3/F3, FIP/BIP and LB/FB primers and one mix with all primers (using Taq and its solutions, of course)with its negative control, respectively.. I realized all negative controls for each reaction were OK. Even the all primer mixed control was OK.
So I repeat the LAMP and again the same result the negative control is a lader pattern-like...will it be possible some LAMP reactive is contaminated?, but I change all a lot of time!..
And in this wall I have read that this problem seems to be comun.
Someone could fix it?
I'll be thankful if one of you could help me!
Reply to: Would anyone please explain why the example below is not being followed.
The Guidelines issued by Public Health England in the previous comment may be a bit indistinct, and so I am repeating the website https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/461295/2015.09.16_ACMP_guidelines_FINAL.pdf
These guidelines/report on the current state of malaria elimination seem to have changed little since the League of Nations Malaria Commisssion reported in 1924!!
Reply to: E-interview with Dr. Silas Majambere (Burundi, 1975)
Congratulations on your new position, Dr. Silas. At the 2013 Jerusalem conference, we were all impressed by your passion for improving larval control methods in Africa. And I am sure you will lend a great boost to the work of the Innovative Vector Control Consortium, based on your wide experience in Gambia, Zanzibar and elsewhere in Africa.......
Also I particularly appreciate your recognition in this e-interview that malaria is a disease of poverty and of the consequent unfavorable conditions of housing and health care. In that vein, I hope you will continue to explore the role of safe and healthy housing as a potential component in the program of the IVCC. As you showed in southern Tanzania, healthy housing - with intensive prevention of mosquito access through eaves, windows and doors - is a basic need for completely suppressing anopheline biting. Furthermore safe and health housing is a basic human need.
Congratulations from myself and from Judith, my wife.
Reply to: Open-source satellite enumeration to map households: planning and targeting indoor residual spraying for malaria
It is gratifying to see the mix of African and American malaria people who reported on this use of satellite imagery to improve the indoor spraying program against malaria in northern Zambia during the 2014 spray season. This is the way that a cadre of experienced African malaria people will be built. It is also noteworthy to see the speed with which this work was reported - from satellite enumeration of households to publication in just one year. Congratulations!--