Our Mission

We envision a world in which there is free and unrestricted access to information on malaria, independent of geographical locality or socio-economic status. No matter who you are, where you are, or what you do, access to information is the key to knowledge.
 
Knowledge empowers. Empowered people prevent and control malaria better.

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Plasmodium falciparum immunodetection in bone remains of members of the Renaissance Medici family (Florence, Italy, sixteenth century)

Author(s): 
Gino Fornaciari, Valentina Giuffra, Ezio Ferroglio, Sarah Gino, Raffaella Bianucci
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 9, September 2010, Pages 583-587
Contact email: 
g.fornaciari@med.unipi.it

Our findings provide the first modern laboratory evidence of the presence of P. falciparum ancient proteins in the skeletal remains of four members of the Medici family. We confirm the clinical diagnosis of the court physicians, using modern methods.

Open Access | Examining appropriate diagnosis and treatment of malaria: availability and use of rapid diagnostic tests and artemisinin-based combination therapy in public and private health facilities in south east Nigeria

Author(s): 
Uzochukwu BS, Chiegboka LO, Enwereuzo C, Nwosu U, Okorafor D, Onwujekwe OE, Uguru NP, Sibeudu FT, Ezeoke OP
Reference: 
BMC Public Health 2010, 10:486 (16 August 2010)
Contact email: 
bscuzochukwu@yahoo.com

The study was undertaken in Enugu state, southeast Nigeria in March 2009. Data was collected from heads of 74 public and private health facilities on the availability and use of RDTs and ACTs. Also, the availability of RDTs and the types of ACTs that were available in the facilities were documented.

A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice

Author(s): 
Fernanda G., Daniel Y., et al
Reference: 
Vaccine, Volume 28, Issue 38, 31 August 2010, Pages 6183-6190
Contact email: 
isoares@usp.br

These results demonstrate that a recombinant protein containing PvAMA-1 DII is immunogenic when administered in different adjuvant formulations, and indicate that this region of the AMA-1 protein should continue to be evaluated as part of a subunit vaccine against vivax malaria.

Open Access | Malaria risk in Corsica, former hot spot of malaria in France

Author(s): 
Toty C, Barre H, Le Goff G, Larget-Thiery I, Rahola N, Couret D, Fontenille D
Reference: 
Malaria Journal 2010, 9:231 (12 August 2010)
Contact email: 
celine.toty@ird.fr

The prevalence of Plasmodium falciparum and Plasmodium vivax malaria was very high in Corsica just before the Second World War. The last outbreak was in 1972 and the most recent indigenous case was in 2006.

Open Access | Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria

Author(s): 
Essuman VA, Ntim-Amponsah CT, Astrup BS, Adjei GO, Kurtzhals JA, Ndanu TA, Goka B
Reference: 
Malaria Journal 2010, 9:232 (12 August 2010)
Contact email: 
vadessuman@yahoo.com

This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children.

Open Access | Synergy in Efficacy of Fungal Entomopathogens and Permethrin against West African Insecticide-Resistant Anopheles gambiae Mosquitoes

Author(s): 
Marit Farenhorst, Bart G. J. Knols, Matthew B. Thomas, Annabel F. V. Howard, Willem Takken, Mark Rowland, Raphael N’Guessan
Reference: 
PLoS ONE 5(8): e12081
Contact email: 
marit.farenhorst@wur.nl

Combining fungi and permethrin induced a higher impact on mosquito survival than the use of these control agents alone.

Open Access | Detection of mixed Plasmodium falciparum & P. vivax infections by nested-PCR in Pakistan, Iran & Afghanistan

Author(s): 
Sedigheh Zakeri, Qutbuddin Kakar, Faezeh Ghasemi, Ahmad Raeisi, Waqar Butt, Najibullah Safi, Mandana Afsharpad, Muhammad Suleiman Memon, Saber Gholizadeh, Masoud Salehi, Hoda Atta, Ghasem Zamani, Navid Dinparast Djadid
Reference: 
Indian J Med Res 132, July 2010, pp 31-35
Contact email: 
zakeris@yahoo.com

The present data suggest the need for improving microscopy diagnosis method and the clinician should also have careful clinical observation, along with the reports on Giemsa-stained thick blood films, particularly in summer time when P. vivax is predominant.

Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission

Author(s): 
Andrew M. Blagborough, Shigeto Yoshida, Jetsumon Sattabongkot, Takafumi Tsuboi, Robert E. Sinden
Reference: 
Vaccine, Volume 28, Issue 37, 23 August 2010, Pages 6014-6020

This study offers a novel tool for the development of malarial transmission-blocking vaccines against the sexual stages of the parasite, using the Baculovirus Dual Expression System that functions as both a subunit, and DNA based vaccine.

Open Access | Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies

Author(s): 
Jamie T. Griffin, T. Deirdre Hollingsworth, Lucy C. Okell, Thomas S. Churcher, Michael White, Wes Hinsley, Teun Bousema, Chris J. Drakeley, Neil M. Ferguson, María-Gloria Basáñez, Azra C. Ghani
Reference: 
PLoS Med 7(8): e1000324
Contact email: 
a.ghani@imperial.ac.uk

Interventions using current tools can result in major reductions in P. falciparum malaria transmission and the associated disease burden in Africa.

Open Access | Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

Author(s): 
Michelle J. Boyle, Danny W. Wilson, Jack S. Richards, David T. Riglar, Kevin K. A. Tetteh, David J. Conway, Stuart A. Ralph,Jake Baum, James G. Beeson
Reference: 
PNAS 2010 Vol 107 No 32 14378-14383
Contact email: 
beeson@wehi.edu.au

During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs.

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