Our Mission

We envision a world in which there is free and unrestricted access to information on malaria, independent of geographical locality or socio-economic status. No matter who you are, where you are, or what you do, access to information is the key to knowledge.
 
Knowledge empowers. Empowered people prevent and control malaria better.

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Open Access | Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1

Author(s): 
Pandey JP, Morais CG, Fontes CJ, Braga EM
Reference: 
Malaria Journal 2010, 9:229 (9 August 2010)
Contact email: 
pandeyj@musc.edu

Results presented here show that immunoglobulin GM allotypes contribute to the natural antibody responses to P. vivax malaria antigens. These findings have important implications for the effectiveness of vaccines containing PvAMA-1 or PvMSP1-19 antigens.

Open Access | Anopheles larval abundance and diversity in three rice agro-village complexes Mwea irrigation scheme, central Kenya

Author(s): 
Mwangangi JM, Shililu J, Muturi EJ, Muriu S, Jacob B, Kabiru EW, Mbogo CM, Githure J, Novak RJ
Reference: 
Malaria Journal 2010, 9:228 (9 August 2010)

These results suggest that agricultural practices have significant influence on mosquito species diversity and abundance and that certain habitat characteristics favor production of malaria vectors.

Open Access | Artemisone effective against murine cerebral malaria

Author(s): 
Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan H, Chan W, Barenholz Y, Haynes RK, Golenser J
Reference: 
Malaria Journal 2010, 9:227 (9 August 2010)
Contact email: 
jhwaknine@gmail.com

Altogether, the results support the use of artemisone for combined therapy of CM.

Open Access | Book review: Review of "A realistic strategy for fighting malaria in Africa" by William Jobin

Author(s): 
Bart GJ Knols
Reference: 
Parasites & Vectors 2010, 3:68
Contact email: 
bart@malariaworld.org

"Jobin’s book, however, serves as a contrasting wake-up call, and tries to shed light on what he claims to be ‘the mess we are currently making in Africa’. "

Quantitative Imaging of Human Red Blood Cells Infected with Plasmodium falciparum

Author(s): 
A Esposito, JB Choimet, JN Skepper, JM Mauritz, VL Lew, CF Kaminski, T Tiffert
Reference: 
Biophysical Journal, Volume 99, Issue 3, 953-960, 4 August 2010
Contact email: 
ae275@cam.ac.uk

During its 48 h asexual reproduction cycle, the malaria parasite Plasmodium falciparum ingests and digests hemoglobin in excess of its metabolic requirements and causes major changes in the homeostasis of the host red blood cell (RBC).

Arterolane, a New Synthetic Trioxolane for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Phase II, Multicenter, Randomized, Dose-Finding Clinical Trial

Author(s): 
N Valecha, S Looareesuwan, A Martensson, SM Abdulla, S Krudsood, N Tangpukdee, S Mohanty, SK Mishra, PK Tyagi, SK Sharma, J Moehrle, A Gautam, A Roy, JK Paliwal, M Kothari, N Saha, AP Dash, A örkman
Reference: 
Clinical Infectious Diseases 2010;51:000–000
Contact email: 
neenavalecha@gmail.com

Arterolane at daily doses of 100 and 200 mg is a rapidly acting, effective, and safe synthetic antimalarial drug, which may potentially represent an alternative to artemisinin derivatives in antimalarial combination therapy.

Fetal Immune Activation to Malaria Antigens Enhances Susceptibility to In Vitro HIV Infection in Cord Blood Mononuclear Cells

Author(s): 
K Steiner, L Myrie, I Malhotra, P Mungai, E Muchiri, A Dent, CL King
Reference: 
The Journal of Infectious Diseases 2010;202:000–000
Contact email: 
christopher.king@case.edu

Mother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) remains a significant cause of new HIV infections in many countries.

Open Access | Mosquito fauna and perspectives for integrated control of urban vector-mosquito populations in Southern Benin (West Africa)

Author(s): 
A Lingenfelser, K Rydzanicz, A Kaiser, N Becker
Reference: 
Ann Agric Environ Med 2010, 17, 49–57.
Contact email: 
kabs-gfs@t-online.de

This study aims at an integrated vector management (IVM) concept of implementing biological control agents against vector mosquito larvae as a cost-effective and scalable control strategy.

Comparative Analysis of Stage Specific Gene Regulation of Apicomplexan Parasites: Plasmodium falciparum and Toxoplasma gondii

Author(s): 
M. Gopalakrishnan, Anusha; Lopez-Estrano, Carlos
Reference: 
Infectious Disorders - Drug Targets, Volume 10, Number 4, August 2010, pp. 303-311(9)

Apicomplexans comprise some of the most life threatening parasites infecting human and livestock and includes Plasmodium and Toxoplasma, the causative agents of malaria and toxoplasmosis respectively, in humans as well as Neospora caninum (abortion in livestock, neosporosis in dogs), Cryptosporidium (Diarrheal cryptosporidiosis and opportunistic infections in AIDS patients) and Eimeria (poultry coccidiosis).

Synthesis, Structure-Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

Author(s): 
SJ Burgess, JX Kelly, S Shomloo, S Wittlin, R Brun, K Liebmann, DH Peyton
Reference: 
J. Med. Chem. August 4, 2010
Contact email: 
peytond@pdx.edu

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum

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