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Scientific Articles

Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

March 30, 2015 - 17:26 -- Open Access
Author(s): 
Carlos Escobar, Sara Pateira, Elsa Lobo, Lis Lobo, Rosa Teodosio, Fernanda Dias, Natercia Fernandes, Ana Paula Arez, Luis Varandas, Fatima Nogueira
Reference: 
PLoS ONE 10(3): e0119215

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem.

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NOT Open Access | Splenic abscess: Plasmodium vivax with secondary Escherichia coli infection

March 30, 2015 - 17:23 -- NOT Open Access
Author(s): 
Laxmikant Ramkumarsingh Tomar, Ranjith Rajendran, Santosh Kumar Pandey, and Amitesh Aggarwal
Reference: 
Trop Doct April 2015 vol. 45 no. 2 143-145

Splenic abscess is a rare clinical entity as described in literature.

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NOT Open Access | Complicated malaria: A rare presentation of Plasmodium ovale

March 30, 2015 - 17:21 -- NOT Open Access
Author(s): 
Laxmikant Ramkumarsingh Tomar, Subhash Giri, Nitesh Kumar Bauddh, and Rajat Jhamb
Reference: 
Trop Doct April 2015 vol. 45 no. 2 140-142

Malaria has emerged as a major public health problem worldwide.

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Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design

March 30, 2015 - 17:19 -- Open Access
Author(s): 
Edwin Chen, Nichole D. Salinas, Francis B. Ntumngia, John H. Adams, Niraj H. Tolia
Reference: 
PLoS Negl Trop Dis 9(3): e0003644

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes.

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NOT Open Access | New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential

March 30, 2015 - 17:16 -- NOT Open Access
Author(s): 
Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Michal Kohout, Matthias Gehringer, Stefan Laufer, Mario Pink, Simone Schmitz-Spanke, Christina Strube, Annette Kaiser
Reference: 
Amino Acids, February 2015, 26 Feb 2015

Deoxyhypusine hydroxylase (DOHH) is a dinuclear iron enzyme required for hydroxylation of the aminobutyl side chain of deoxyhypusine in eukaryotic translation initiation factor 5A (eIF-5A), the second step in hypusine biosynthesis.

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NOT Open Access | Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite

March 26, 2015 - 10:25 -- NOT Open Access
Author(s): 
Anil K. Singh, Vinoth Rajendran, Akansha Pant, Prahlad C. Ghosh, Neelu Singh, N. Latha, Sandeep Garg, Kailash C. Pandey, Brajendra K. Singh, Brijesh Rathi
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 8, 15 April 2015, Pages 1817–1827

Phthalimides functionalized with cyclic amines were synthesized, characterized and screened for their in vitro antimalarial efficacy against Plasmodium falciparum (Pf3D7).

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Factors Associated with Malaria Parasitemia, Anemia and Serological Responses in a Spectrum of Epidemiological Settings in Uganda

March 26, 2015 - 10:23 -- Open Access
Author(s): 
Adoke Yeka, Joaniter Nankabirwa, Arthur Mpimbaza, Ruth Kigozi, Emmanuel Arinaitwe, Chris Drakeley, Bryan Greenhouse, Moses R. Kamya, Grant Dorsey, Sarah G. Staedke
Reference: 
PLoS ONE 10(3): e0118901

Anemia was predominant in young children and parasitemia peaked by 11 years across 3 sites with varied transmission intensity.

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Iron Prevents the Development of Experimental Cerebral Malaria by Attenuating CXCR3-Mediated T Cell Chemotaxis

March 26, 2015 - 10:22 -- Open Access
Author(s): 
Kristin M. Van Den Ham, Marina Tiemi Shio, Anthony Rainone, Sylvie Fournier, Connie M. Krawczyk, Martin Olivier
Reference: 
PLoS ONE 10(3): e0118451

Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection.

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NOT Open Access | Ritonavir-boosted indinavir but not lopinavir inhibits erythrocytic stage Plasmodium knowlesi malaria in rhesus macaques

March 25, 2015 - 15:50 -- NOT Open Access
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Author(s): 
Li Qin, Limei Qin, Wanwan Xu, Siting Zhao, Xiaoping Chen
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 7, 1 April 2015, Pages 1538–1540

The inhibitive activities of the human immunodeficiency virus protease inhibitors ritonavir (RTV) boosted indinavir (IDV) and RTV boosted lopinavir (LPV) for erythrocytic stage malaria were evaluated in rhesus macaques

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NOT Open Access | Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies

March 25, 2015 - 15:49 -- NOT Open Access
Author(s): 
Zhong-Ke Yao, Priscilla M. Krai, Emilio F. Merino, Morgan E. Simpson, Carla Slebodnick, Maria Belen Cassera, Paul R. Carlier
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 7, 1 April 2015, Pages 1515–1519

Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) pathway used by the parasite is not present in humans.

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