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Scientific Articles

Decrease of larval and subsequent adult Anopheles sergentii populations following feeding of adult mosquitoes from Bacillus sphaericus-containing attractive sugar baits

April 25, 2015 - 10:27 -- Open Access
Author(s): 
Yosef Schlein and Günter C Müller
Reference: 
Parasites & Vectors 2015, 8:244

By the end of the study period, the larval population at the experimental site was six-fold smaller than the concurrent larval population at the control site. The ensuing adult An. sergentii population was also reduced to about 60% at the experimental site, while the adult mosquito population at the control site had increased 2.4 fold over the same time-frame.

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Long non-coding RNA discovery across the genus anopheles reveals conserved secondary structures within and beyond the Gambiae complex

April 25, 2015 - 10:23 -- Open Access
Author(s): 
Adam M Jenkins, Robert M Waterhouse and Marc AT Muskavitch
Reference: 
BMC Genomics 2015, 16:337

This study offers one of the first lncRNA secondary structure analyses in vector insects. Our description of lncRNAs in An. gambiae offers the most comprehensive genome-wide insights to date into lncRNAs in this vector mosquito, and defines a set of potential targets for the development of vector-based interventions that may further curb the human malaria burden in disease-endemic countries.

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NOT Open Access | Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells

April 24, 2015 - 09:23 -- NOT Open Access
Author(s): 
Michael R. Baldwin, Xuerong Li, Toshihiko Hanada, Shih-Chun Liu, and Athar H. Chishti
Reference: 
Blood: 125 (17), April 23, 2015

Plasmodium falciparum invasion of human red blood cells (RBCs) is an intricate process requiring a number of distinct ligand-receptor interactions at the merozoite-erythrocyte interface.

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NOT Open Access | The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides

April 24, 2015 - 09:21 -- NOT Open Access
Author(s): 
Leo Syrjänen, Marianne Kuuslahti, Martti Tolvanen, Daniela Vullo, Seppo Parkkila, Claudiu T. Supuran
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 10, 15 May 2015, Pages 2303–2309

A β-carbonic anhydrase (CA, EC 4.2.1.1) was cloned, purified and characterized from Anopheles gambiae, the mosquito species mainly involved in the transmission of malaria.

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NOT Open Access | Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme

April 24, 2015 - 09:20 -- NOT Open Access
Author(s): 
Adriana Fonseca Marques, Priscila S.F.C. Gomes, Pedro L. Oliveira, Philip J. Rosenthal, Pedro G. Pascutti, Luis Mauricio T.R. Lima
Reference: 
Archives of Biochemistry and Biophysics, Volume 573, 1 May 2015, Pages 92–99

During the erythrocytic cycle of Plasmodium falciparum malaria parasites break down host hemoglobin, resulting in the release of free heme (ferriprotoporphyrin IX).

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NOT Open Access | Recent Developments in Malaria Vaccinology

April 24, 2015 - 09:18 -- NOT Open Access
Author(s): 
Benedict R. Halbroth, Simon J. Draper
Reference: 
Advances in Parasitology, Volume 88, April 2015, Pages 1–49

The development of a highly effective malaria vaccine remains a key goal to aid in the control and eventual eradication of this devastating parasitic disease.

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The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment

April 24, 2015 - 09:16 -- Open Access
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Author(s): 
Betty A Maganda, Eliford Ngaimisi, Appolinary Kamuhabwa, Eleni Aklillu, Omary Minzi
Reference: 
Malaria Journal 2015, 14:179 (25 April 2015)

Co-treatment of AL with EFV-based ART but not NVP-based ART significantly reduces lumefantrine bioavailability and consequently total exposure.

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Re-imagining the control of malaria in tropical Africa during the early years of the World Health Organization

April 24, 2015 - 09:13 -- Open Access
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Author(s): 
Socrates Litsios
Reference: 
Malaria Journal 2015, 14:178 (24 April 2015)

This paper grew out of a meeting organized in October 2014 in London on ‘Re-imagining malaria’.

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Characterization of imported malaria, the largest threat to sustained malaria elimination from Sri Lanka

April 24, 2015 - 09:06 -- Open Access
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Author(s): 
Priyani Dharmawardena, Risintha G Premaratne, WM de AW Gunasekera, Mihirini Hewawitarane, Kamini Mendis, Deepika Fernando
Reference: 
Malaria Journal 2015, 14:177 (24 April 2015)

Sri Lanka has reached zero indigenous malaria cases in November 2012, two years before its targeted deadline for elimination.

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Plasmodium vivax malaria at households: spatial clustering and risk factors in a low endemicity urban area of the northwestern Peruvian coast

April 24, 2015 - 09:05 -- Open Access
Author(s): 
Angel Rosas-Aguirre, Oscar J Ponce, Gabriel Carrasco-Escobar, Niko Speybroeck, Juan Contreras-Mancilla, Dionicia Gamboa, Edwar Pozo, Sócrates Herrera, Alejandro Llanos-Cuentas
Reference: 
Malaria Journal 2015, 14:176 (24 April 2015)

Plasmodium vivax malaria incidence is highly heterogeneous in space and time in the urban study area with important geographical and housing risk factors associated with symptomatic episodes.

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