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Scientific Articles

Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti

September 30, 2014 - 09:00 -- Open Access
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Author(s): 
von Fricken ME, Weppelmann TA, Lam B, Eaton WT, Schick L, Masse R, Beau De Rochars MV, Existe A, Larkin J, Okech BA
Reference: 
Malaria Journal 2014, 13 :361 (14 September 2014)

These findings suggest that despite the absence of sustained malaria control efforts in Haiti, transmission has remained relatively low over multiple decades.

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A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

September 30, 2014 - 08:59 -- Open Access
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Author(s): 
F. Joel Leong, Ruobing Li, Jay Prakash Jain, Gilbert Lefèvre, Baldur Magnusson, Thierry T. Diagana, and Peter Pertel
Reference: 
Antimicrob. Agents Chemother. October 2014 vol. 58 no. 10 6209-6214

This first-in-human randomized, double-blind, placebo-controlled, ascending-single and -multiple oral dose study was designed to evaluate the safety, tolerability, and pharmacokinetics in healthy volunteers of KAE609 (cipargamin; formerly NITD609), a spiroindolone now in trials for malaria treatment.

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Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

September 29, 2014 - 16:39 -- Open Access
Author(s): 
Raquel González , Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
Reference: 
PLoS Med 11(9): e1001733

The study arms were: (1) SP, (2) single dose MQ (15 mg/kg), and (3) split-dose MQ in the context of long lasting insecticide treated nets. There was no difference on low birth weight prevalence (primary study outcome) between groups (360/2,778 [13.0%]) for MQ group and 177/1,398 (12.7%) for SP group; risk ratio [RR], 1.02 (95% CI 0.86–1.22; p = 0.80 in the ITT analysis).

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Malaria Prevention during Pregnancy—Is There a Next Step Forward?

September 29, 2014 - 16:34 -- Open Access
Author(s): 
Richard W. Steketee
Reference: 
PLoS Med 11(9): e1001734

This burden of malaria during pregnancy was first described in the scientific literature in 1935 [1] and further elucidated through studies in the 1950s to 1980s [2]; the specific additional burden in HIV-infected women was described in the 1990s as the HIV epidemic spread widely .

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Insecticide-treated net wall hangings for malaria vector control: an experimental hut study in north-eastern Tanzania

September 25, 2014 - 12:57 -- Open Access
Author(s): 
Ngufor C, Tungu P, Malima R, Kirby M, Kisinza W, Rowland M
Reference: 
Malaria Journal 2014, 13 :366 (17 September 2014)

To determine the optimum level of wall coverage required, NWH were tested on ceiling only, two walls, four walls, or four walls plus ceiling. Comparison was made with deltamethrin-treated NWH on two walls.

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Impairment of executive function in Kenyan children exposed to severe falciparum malaria with neurological involvement

September 25, 2014 - 12:43 -- Open Access
Author(s): 
Kariuki SM, Abubakar A, Newton CR, Kihara M
Reference: 
Malaria Journal 2014, 13 :365 (16 September 2014)

Linear regression was used to determine the association between neurological phenotypes of severe malaria and executive function performance scores, accounting for potential confounders.

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Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali

September 25, 2014 - 12:40 -- Open Access
Author(s): 
Coulibaly D, Travassos MA, Thera MA, et al.
Reference: 
Malaria Journal 2014, 13 :374 (19 September 2014)

To document malaria incidence, a cohort of 400 children aged 0 to 14 years was followed for three to four years up to July 2013. Monthly cross-sectional surveys were done to measure the prevalence of malaria infection and anaemia.

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Detection of Plasmodium knowlesi DNA in the urine and faeces of a Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection

September 25, 2014 - 12:37 -- Open Access
Author(s): 
Kawai S, Sato M, Kato-Hayashi N, Kishi H, Huffman MA, Maeno Y, Culleton R, Nakazawa S
Reference: 
Malaria Journal 2014, 13 :373 (19 September 2014)

Urine and faeces were obtained from a Plasmodium knowlesi infected-Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection. P. knowlesi DNA (PkDNA) extracted from urine and faeces were monitored by nested PCR targeting the P. knowlesi specific cytochrome b (cytb) gene.

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Analysis of polymorphisms in Plasmodium falciparum genes related to drug resistance: a survey over four decades under different treatment policies in Brazil

September 25, 2014 - 12:29 -- Open Access
Author(s): 
Inoue J, Lopes D, do Rosário V, Machado M, Hristov AD, Lima GF, Costa-Nascimento MJ, Segurado AC, Di Santi SM
Reference: 
Malaria Journal 2014, 13 :372 (19 September 2014)

The analysis of pfmdr1 copy number showed amplification in 37.3% in period 1 and in 42% in period 2. Mutations in pfdhfr were shown as follows: 51I in all samples in period 1 and in 81.2% in period 2; 59R in 6.4% in period 2. The pfdhfr 108N and the pfdhps 437G were seen in all samples along time; the pfdhps 540E in 93.7% in period 1 and in 75% in period 2.

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Novel approaches to risk stratification to support malaria elimination: an example from Cambodia

September 25, 2014 - 12:17 -- Open Access
Author(s): 
Cox J, Sovannaroth S, Dy Soley L, Ngor P, Mellor S, Roca-Feltrer A
Reference: 
Malaria Journal 2014, 13 :371 (19 September 2014)

This paper explores the utility of routine malaria surveillance data for the stratification of malaria risk in Cambodia, where the target is malaria elimination by 2025.

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