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Scientific Articles

Exploring immunological mechanisms of the whole sporozoite vaccination against P. falciparum malaria

July 31, 2015 - 17:17 -- Open Access
Author(s): 
Annie X.Y. Mo, John Pesce, B. Fenton Hall
Reference: 
Vaccine, Volume 33, Issue 25, 9 June 2015, Pages 2851-2857

The workshop discussed the current understanding of host immune responses to whole malaria sporozoite inoculation, identified gaps in knowledge, resources to facilitate progress, and applicable new technologies and approaches to accelerate immunologic and vaccinologic studies and biomarker identification. 

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Not Open Access | Assessing the economic benefits of vaccines based on the health investment life course framework: A review of a broader approach to evaluate malaria vaccination

July 31, 2015 - 17:12 -- NOT Open Access
Author(s): 
Dagna Constenla
Reference: 
Vaccine, Volume 33, Issue 13, 24 March 2015, Pages 1527-1540

We describe a framework that measures the impact of a health policy decision on government accounts over many generations. The methodological issues emerging from this approach are illustrated with an example from a recently completed health investment life course analysis of malaria vaccination in Ghana.

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The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro

July 31, 2015 - 17:04 -- Open Access
Author(s): 
K.A. Sala, H. Nishiura, L.M. Upton, S.E. Zakutansky, M.J. Delves, M. Iyori, M. Mizutani, R.E. Sinden, S. Yoshida, A.M. Blagborough
Reference: 
Vaccine, Volume 33, Issue 3, 9 January 2015, Pages 437-445

Here we describe the design and evaluation of a potential TBV (BDES-PbPSOP12) targeting Plasmodium berghei PSOP12 based on the baculovirus dual expression system (BDES), enabling expression of antigens on the surface of viral particles and within infected mammalian cells. 

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Not Open Access | Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization

July 31, 2015 - 17:01 -- NOT Open Access
Author(s): 
Mayumi Tachibana, Nantavadee Suwanabun, Takafumi Tsuboi, et al.
Reference: 
Vaccine, Volume 33, Issue 16, 15 April 2015, Pages 1901-1908

 Herein we investigated whether targeting Pvs48/45 and Pvs47 can inhibit parasite transmission to mosquitoes, using P. vivax isolates obtained in Thailand. Mouse antisera directed against the products from plasmids expressing Pvs48/45 and Pvs47 detected proteins of approximately 45- and 40-kDa, respectively, in the P. vivax gametocyte lysate, by Western blot analysis under non-reducing conditions. 

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Multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants per genome can bind IgM via Fcμ

July 31, 2015 - 16:08 -- Open Access
Author(s): 
Anine Jeppesen, Sisse Bolm Ditlev, Vladyslav Soroka, Liz Stevenson, Louise Turner, Ron Dzikowski, Lars Hviid, and Lea Barfod
Reference: 
Infect. Immun

Our study provides new evidence regarding Fc-dependent binding of IgM to PfEMP1, which appears to be a common and multifunctional phenotype.

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Not Open Access | Design of a Phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine

July 31, 2015 - 16:02 -- NOT Open Access
Author(s): 
Isabelle Delrieu, Didier Leboulleux, Karen Ivinson, Bradford D. Gessner
Reference: 
Vaccine, Volume 33, Issue 13, 24 March 2015, Pages 1518-1526

Sample size estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist.

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Not Open Access | Induction of CD8+ T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine

July 31, 2015 - 15:53 -- NOT Open Access
Author(s): 
Frances E. Pearson, Conor O’Mahony, Anne C. Moore, Adrian V.S. Hill
Reference: 
Vaccine, Volume 33, Issue 28, 22 June 2015, Pages 3248-3255

Here, we aimed to investigate immunity induced by the recombinant simian adenovirus-vectored vaccine ChAd63.ME-TRAP; currently undergoing clinical assessment as a candidate malaria vaccine, when delivered percutaneously by silicon microneedle arrays. 

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The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?

July 31, 2015 - 15:16 -- Open Access
Author(s): 
Patrick M Lelliott, Brendan J McMorran, Simon J Foote, Gaetan Burgio
Reference: 
Malaria Journal 2015, 14:289 (29 July 2015)

As parasites, Plasmodium species depend upon their host for survival.

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Genetic variation of pfhrp2 in Plasmodium falciparum isolates from Yemen and the performance of HRP2-based malaria rapid diagnostic test

July 28, 2015 - 14:37 -- Open Access
Author(s): 
Atroosh W, Al-Mekhlafi H, Surin J, et al.
Reference: 
Parasites & Vectors 2015, 8 :388 (22 July 2015)

The present study provides data on the genetic variation within the pfhrp2 gene, and its potential impact on the PfHRP2-based RDTs commonly used in Yemen. 

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Not Open Access | Fitness of artemisinin-resistant Plasmodium falciparum in vitro

July 28, 2015 - 14:33 -- NOT Open Access
Author(s): 
Amanda Hott, Matthew S. Tucker, Debora Casandra, Kansas Sparks and Dennis E. Kyle
Reference: 
J. Antimicrob. Chemother. (2015)

We experimentally demonstrate for the first time that artemisinin resistance provides a fitness advantage that is selected for with infrequent exposure to drug, but is lost in the absence of exposure to artemisinin drugs. 

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