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Scientific Articles

Severe Malaria Not Responsive to Artemisinin Derivatives in Man Returning from Angola to Vietnam

May 20, 2015 - 15:52 -- Open Access
Author(s): 
Pascal Ringwald and Arjen M. Dondorp
Reference: 
Emerging Infectious Diseases , Volume 21, Number 7—July 2015

Thus, vigilant monitoring is pivotal, and it is therefore with great interest that we read the case report on a patient in Vietnam with severe P. falciparum malaria, acquired in Angola in 2013, that was not responsive to artesunate or several other antimalarial combinations

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Not Open Access | Early Effector Cells Survive the Contraction Phase in Malaria Infection and Generate Both Central and Effector Memory T Cells

May 20, 2015 - 15:35 -- NOT Open Access
Author(s): 
Michael M. Opata, Victor H. Carpio, Samad A. Ibitokou, Brian E. Dillon, Joshua M. Obiero and Robin Stephen
Reference: 
The Journal of Immunology June 1, 2015 vol. 194 no. 11 5346-5354

Using adoptive transfer, we show that only early Teff survive the contraction phase and generate the terminal late Teff subsets, whereas in uninfected recipients, they become both central and effector Tmem.

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Prescriber and patient-oriented behavioural interventions to improve use of malaria rapid diagnostic tests in Tanzania: facility-based cluster randomised trial

May 20, 2015 - 15:27 -- Open Access
Author(s): 
Bonnie Cundill, Hilda Mbakilwa, Hugh Reyburn, et al.
Reference: 
BMC Medicine 2015, 13:118

The primary outcome was the proportion of patients with a non-severe, non-malarial illness incorrectly prescribed a (recommended) antimalarial. Secondary outcomes investigated RDT uptake, adherence to results, and antibiotic prescribing.

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Not Open Access | A Simple Real-Time PCR and Amplicon Sequencing Method for Identification of Plasmodium Species in Human Whole Blood

May 20, 2015 - 15:12 -- NOT Open Access
Author(s): 
Lefterova MI, Budvytiene I, Sandlund J, Färnert A, Banaei N
Reference: 
J Clin Microbiol. 2015 May 13. pii: JCM.00542-15.

Here we describe a SYBR Green-based real-time PCR assay for Plasmodium species identification from whole blood, which uses a panel of reactions to detect species-specific non-18S rRNA gene targets.

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Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity

May 19, 2015 - 06:20 -- Open Access
Author(s): 
David J. Sullivan, Yi Liu, Bryan T. Mott, Nikola Kaludov, Martin N. Martinov
Reference: 
PLoS ONE 10(5): e0125593

Without quantum theory any understanding of molecular interactions is incomplete.

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NOT Open Access | Dendritic cells subsets mediated immune response during Plasmodium berghei ANKA and Plasmodium yoelii infection

May 19, 2015 - 06:15 -- NOT Open Access
Author(s): 
Tarun Keswani, Anirban Sengupta, Samrat Sarkar, Arindam Bhattacharyya
Reference: 
Cytokine, Volume 73, Issue 2, June 2015, Pages 198–206

The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood.

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Mechanisms of Stage-Transcending Protection Following Immunization of Mice with Late Liver Stage-Arresting Genetically Attenuated Malaria Parasites

May 19, 2015 - 05:47 -- Open Access
Author(s): 
Brandon K. Sack, Gladys J. Keitany, Ashley M. Vaughan, Jessica L. Miller, Ruobing Wang, Stefan H. I. Kappe
Reference: 
PLoS Pathog 11(5): e1004855

Malaria, caused by Plasmodium parasite infection, continues to be one of the leading causes of worldwide morbidity and mortality.

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Prospects for Malaria Elimination in Mesoamerica and Hispaniola

May 19, 2015 - 05:45 -- Open Access
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Author(s): 
Sócrates Herrera, Sergio Andrés Ochoa-Orozco, Iveth J. González, Lucrecia Peinado, Martha L. Quiñones, Myriam Arévalo-Herrera
Reference: 
PLoS Negl Trop Dis 9(5): e0003700

Malaria remains endemic in 21 countries of the American continent with an estimated 427,000 cases per year.

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NOT Open Access | A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

May 18, 2015 - 14:44 -- NOT Open Access
Author(s): 
Cristiano J. Macuamule, Erick T. Tjhin, Collins E. Jana, Leanne Barnard, Lizbé Koekemoer, Marianne de Villiers, Kevin J. Saliba, and Erick Strauss
Reference: 
Antimicrob. Agents Chemother. June 2015 vol. 59 no. 6 3666-3668

Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC50], ∼20 nM) similar to that of chloroquine.

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NOT Open Access | Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

May 18, 2015 - 14:31 -- NOT Open Access
Author(s): 
Amanda Hott, Debora Casandra, Kansas N. Sparks, Lindsay C. Morton, Geocel-Grace Castanares, Amanda Rutter, and Dennis E. Kyle
Reference: 
Antimicrob. Agents Chemother. June 2015 vol. 59 no. 6 3156-3167

Artemisinin derivatives are used in combination with other antimalarial drugs for treatment of multidrug-resistant malaria worldwide

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