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Scientific Articles

Angiopoietin-2 and Angiopoietin-2/Angiopoietin-1 Ratio as Indicators of Potential Severity of Plasmodium vivax Malaria in Patients with Thrombocytopenia

October 16, 2014 - 12:20 -- Open Access
Author(s): 
Luciano Teixeira Gomes, Eduardo Rodrigues Alves-Junior, Clebson Rodrigues-Jesus, Andreia Ferreira Nery, Thamires Oliveira Gasquez-Martin, Cor Jesus Fontes
Reference: 
PLoS ONE 9(10): e109246

This study showed that patients with predictors of worst-case prognoses for P. vivax malaria have lower Ang-1 and higher Ang-2 serum levels (and higher values for the Ang-2/Ang-1 ratio) than controls.

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Benefit of Insecticide-Treated Nets, Curtains and Screening on Vector Borne Diseases, Excluding Malaria: A Systematic Review and Meta-analysis

October 16, 2014 - 12:19 -- Open Access
Author(s): 
Anne L. Wilson, Ramesh C. Dhiman, Uriel Kitron, Thomas W. Scott, Henk van den Berg, Steven W. Lindsay
Reference: 
PLoS Negl Trop Dis 8(10): e3228

There are likely to be considerable collateral benefits of ITN roll out on cutaneous leishmaniasis where this disease is co-endemic with malaria.

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A Full-Length Plasmodium falciparum Recombinant Circumsporozoite Protein Expressed by Pseudomonas fluorescens Platform as a Malaria Vaccine Candidate

October 16, 2014 - 12:17 -- Open Access
Author(s): 
Amy R. Noe, Diego Espinosa, Gabriel M. Gutierrez, et al.
Reference: 
PLoS ONE 9(9): e107764

The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein, which forms a dense coat on the sporozoite's surface.

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Malaria in school-age children in Africa: an increasingly important challenge

October 16, 2014 - 12:15 -- Open Access
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Author(s): 
Joaniter Nankabirwa, Simon J. Brooker, Sian E. Clarke, Deepika Fernando, Caroline W. Gitonga, David Schellenberg and Brian Greenwood
Reference: 
Tropical Medicine & International Health, Volume 19, Issue 11, pages 1294–1309, November 2014

School-age children have attracted relatively little attention as a group in need of special measures to protect them against malaria.

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Not Open Access | Case-management of malaria in children attending an outpatient clinic in southwest Nigeria

October 15, 2014 - 19:06 -- NOT Open Access
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Author(s): 
Iwelunmor J, Belue R, Nwosa I, Adedokun A, Airhihenbuwa CO
Reference: 
Int Q Community Health Educ. 2013;34(3):255-67

This study examined the case-management of malaria in 135 febrile children attending an outpatient clinic in southwest Nigeria. Specifically, we examined the degree of concordance between physician's diagnosis of malaria, maternal perceptions of child febrile illness, and the results of malaria rapid diagnostic tests.

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Future Climate Data from RCP 4.5 and Occurrence of Malaria in Korea

October 15, 2014 - 19:04 -- Open Access
Author(s): 
Janwon Kwak, Huiseong Noh, Soojun Kim, Vijay P. Singh, Seung Jin Hong, Duckgil Kim, Keonhaeng Lee, Narae Kang and Hung Soo Kim
Reference: 
Int. J. Environ. Res. Public Health 2014, 11(10), 10587-10605

The objective of this study is to quantify the effect of climatic factors on the occurrence of malaria in Korea and construct a malaria occurrence model for predicting the future trend of malaria under the influence of climate change.

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Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

October 14, 2014 - 15:52 -- Open Access
Author(s): 
Frank Kloprogge, Vincent Jullien, Patrice Piola, Mehul Dhorda, Sulaiman Muwanga, François Nosten, Nicholas P. J. Day, Nicholas J. White, Philippe J. Guerin and Joel Tarning
Reference: 
J. Antimicrob. Chemother. (2014) 69 (11): 3033-3040.

The aim of this study was to investigate the pharmacokinetic properties of oral quinine in pregnant women with uncomplicated malaria in Uganda using a population approach.

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Environmental management through sluice gated bed-dam: a revived strategy for the control of Anopheles fluviatilis breeding in streams

October 14, 2014 - 15:30 -- Open Access
Author(s): 
Sahu SS, Gunasekaran K, Jambulingam P.
Reference: 
Indian J Med Res. 2014 Aug;140(2):296-301.

In this context, the present study highlights the environmental control of breeding of Anopheles fluviatilis, the primary malaria vector, through water management in a natural stream in Koraput district, Odisha, India.

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The roles and influence of actors in the uptake of evidence: the case of malaria treatment policy change in Uganda

October 14, 2014 - 15:24 -- Open Access
Author(s): 
Juliet Nabyonga-Orem, Miriam Nanyunja, Bruno Marchal, Bart Criel and Freddie Ssengooba
Reference: 
Implementation Science 2014, 9:150

Our results showed a diverse group of stakeholders who played multiple roles, with varying levels of support and influence on the uptake of evidence in the malaria treatment policy change.

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Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial

October 10, 2014 - 17:47 -- Open Access
Author(s): 
Susanne H Hodgson, Prateek Choudhary, Simon J Draper, et al.
Reference: 
Molecular Therapy , 30 September 2014

Here we report on a phase 1a clinical trial using the AMA1 antigen from the blood-stage Plasmodium falciparum malaria parasite delivered either as recombinant protein formulated with Alhydrogel adjuvant with and without CPG 7909, or using recombinant vectored vaccines—chimpanzee adenovirus ChAd63 and the orthopoxvirus MVA.

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