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Scientific Articles

High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays

October 30, 2014 - 16:50 -- Open Access
Author(s): 
Regis W Tiendrebeogo, Bright Adu, Susheel K Singh, Daniel Dodoo, Morten H Dziegiel, Benjamin Mordmüller, Issa Nébié, Sodiomon B Sirima, Michael Christiansen, Michael Theisen
Reference: 
Malaria Journal 2014, 13:412 (20 October 2014)

Here, a high-throughput, three-parameter (tri-colour) flow cytometry technique based on mitotracker red dye, the nucleic acid dye coriphosphine O (CPO) and the leucocyte marker CD45 for enumerating live parasites in bioassays was developed.

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Detection of mixed infection level of Plasmodium falciparum and Plasmodium vivax by SYBR Green I-based real-time PCR in North Gondar, north-west Ethiopia

October 30, 2014 - 16:46 -- Open Access
Author(s): 
Addimas Tajebe, Gabriel Magoma, Mulugeta Aemero, Francis Kimani
Reference: 
Malaria Journal 2014, 13:411 (18 October 2014)

The study was conducted in seven health centres from North Gondar, north-west Ethiopia. The data of all febrile patients, who attended the outpatient department for malaria diagnosis, from October to December 2013, was recorded.

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Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1alpha1 using ELISA and a magnetic bead-based duplex assay (MAGPIX(R)-Luminex) in a Senegalese meso-endemic community

October 30, 2014 - 16:42 -- Open Access
Author(s): 
Ronald Perraut, Vincent Richard, Marie-Louise Varela, Jean-François Trape, Micheline Guillotte, Adama Tall, Aissatou Toure, Cheikh Sokhna, Inès Vigan-Womas, Odile Mercereau-Puijalon
Reference: 
Malaria Journal 2014, 13:410 (17 October 2014)

Use of multiplex assays is a convenient approach to monitor the antibody response against multiple antigens, but to integrate multiplex assay-derived data with datasets, generated previously using ELISA, comparative studies are needed. This work compares antibody responses to two P. falciparum antigens monitored using both technologies.

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Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model

October 30, 2014 - 16:40 -- Open Access
Author(s): 
Susan Fracisco, Paktiya Teja-isavadharm, Montip Gettayacamin, Jonathan Berman, Qigui Li, Victor Melendez, David Saunders, Lisa Xie, Colin Ohrt
Reference: 
Malaria Journal 2014, 13:409 (17 October 2014)

cis-mirinicamycin and trans-mirinicamycin were evaluated as prophylaxis against early liver stages of Plasmodium berghei in mice and as antirelapse hypnozoiticides against Plasmodium cynomolgi in the Rhesus monkey (Macaca mulatta).

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Nationwide assessment of insecticide susceptibility in Anopheles gambiae populations from Zimbabwe

October 30, 2014 - 16:37 -- Open Access
Author(s): 
Nzira Lukwa, Shadreck Sande, Aramu Makuwaza, Tonderai Chiwade, Martin Netsa, Kwame Asamoa, Gonzalo Vazquez-Prokopec, Richard Reithinger, Jacob Williams
Reference: 
Malaria Journal 2014, 13:408 (17 October 2014)

This study reports results of the first nation-wide assessment of insecticide susceptibility in wild populations of Anopheles gambiae sensu lato (s.l.) in Zimbabwe, and provides a comprehensive review of the insecticide resistance status of An. gambiae s.l. in southern African countries.

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Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model

October 30, 2014 - 16:34 -- Open Access
Author(s): 
Catherine Mullié, Nicolas Taudon, Camille Degrouas, Alexia Jonet, Aurélie Pascual, Patrice Agnamey, Pascal Sonnet
Reference: 
Malaria Journal 2014, 13:407 (16 October 2014)

The results obtained make those two (S)-amino-alcohol quinoline derivatives good candidates for the development of new artemisinin-based combination therapy (ACT), hopefully with fewer neurologic side effects than those currently marketed ACT, including MQ.

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Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands

October 30, 2014 - 16:31 -- Open Access
Author(s): 
Karryn J Gresty, Karen-Ann Gray, Albino Bobogare, George Taleo, Jeffrey Hii, Lyndes Wini, Qin Cheng, Norman C Waters
Reference: 
Malaria Journal 2014, 13:406 (15 October 2014)

This study aims to provide baseline data on molecular markers (pfcrt and pfmdr1), along with the origins of pfcrt, prior to the introduction of AL.

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Clinical malaria case definition and malaria attributable fraction in the highlands of western Kenya

October 30, 2014 - 16:29 -- Open Access
Author(s): 
Yaw A Afrane, Guofa Zhou, Andrew K Githeko, Guiyun Yan
Reference: 
Malaria Journal 2014, 13:405 (15 October 2014)

To evaluate the effectiveness of malaria interventions, age-specific case definitions of clinical malaria needs to be determined. Cases of clinical malaria through active case surveillance were quantified in a highland area in Kenya and defined clinical malaria for different age groups.

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A descriptive study of 16 severe Plasmodium vivax cases from three municipalities of Colombia between 2009 and 2013

October 30, 2014 - 16:26 -- Open Access
Author(s): 
Anthony T O’Brien, Jesica F Ramírez, Sandra P Martínez
Reference: 
Malaria Journal 2014, 13:404 (15 October 2014)

The following questions derived from this study could be the basis for future research: 1) Does the time to consultation have an impact on the number of days hospitalized and how cases progress during hospitalization.

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The performance evaluation of a urine malaria test (UMT) kit for the diagnosis of malaria in individuals with fever in south-east Nigeria: cross-sectional analytical study

October 30, 2014 - 16:24 -- Open Access
Author(s): 
Tagbo Oguonu, Elvis Shu, Bertilla U Ezeonwu, Bao Lige, Anne Derrick, Rich E Umeh, Eddy Agbo
Reference: 
Malaria Journal 2014, 13:403 (15 October 2014)

This was an observational study in which a urine-based malaria test kit was used in malaria diagnosis in a normal field setting. Two hundred and three individuals who presented with fever (≥37.5°C) at seven outpatient clinics in Enugu State during periods of high and low transmission seasons in Southeastern Nigeria were enrolled.

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