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Scientific Articles

Impact of a training course on the quality of malaria diagnosis by microscopy in Angola

November 27, 2014 - 17:14 -- Open Access
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Author(s): 
Sofia Moura, Cláudia Fançony, Clara Mirante, Marcela Neves, Luís Bernardino, Filomeno Fortes, Maria do Rosário Sambo, Miguel Brito
Reference: 
Malaria Journal 2014, 13:437 (18 November 2014)

This study was implemented in laboratories from three hospitals in different provinces of Angola: Bengo, Benguela and Luanda. In each laboratory samples were collected before and after the training course (slide with thin and thick blood smears, a dried blood spot and a form).

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In vitro growth of Plasmodium falciparum in neonatal blood

November 27, 2014 - 17:10 -- Open Access
Author(s): 
Ulrich Sauerzopf, Yabo J Honkpehedji, Michael Ramharter, et al.
Reference: 
Malaria Journal 2014, 13:436 (18 November 2014)

These data challenge the concept of HbF serving as intrinsic inhibitor of P. falciparum growth in the first months of life. Erythrocytes containing HbF are equally permissive to P. falciparum growth in vitro.

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Net use, care and repair practices following a universal distribution campaign in Mali

November 27, 2014 - 17:03 -- Open Access
Author(s): 
Lori Leonard, Samba Diop, Seydou Doumbia, Aboubacar Sadou, Jules Mihigo, Hannah Koenker, Sara Berthe, April Monroe, Kathryn Bertram, Rachel Weber
Reference: 
Malaria Journal 2014, 13:435 (18 November 2014)

The study included 40 households, split evenly across the two regions. Forty interviews were conducted with household heads and 151 sleeping spaces were inventoried using the sleeping space questionnaire.

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Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach

November 27, 2014 - 16:57 -- Open Access
Author(s): 
Kevin W Kastner, Douglas A Shoue, Guillermina L Estiu, Julia Wolford, Megan F Fuerst, Lowell D Markley, Jesús A Izaguirre, Mary Ann McDowell
Reference: 
Malaria Journal 2014, 13:434 (18 November 2014)

Two Anopheles gambiae OARs were cloned, analysed and functionally characterized using a heterologous cell reporter system. Four antagonist- and four agonist-binding homology models were generated and virtually screened by docking against compounds obtained from the ZINC database.

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Comparison of detection methods to estimate asexual Plasmodium falciparum parasite prevalence and gametocyte carriage in a community survey in Tanzania

November 26, 2014 - 15:07 -- Open Access
Author(s): 
Felista Mwingira, Blaise Genton, Abdu-Noor M Kabanywanyi, Ingrid Felger
Reference: 
Malaria Journal 2014, 13:433 (18 November 2014)

This study aimed to evaluate the extent of missed infections via a community survey in Tanzania, using polymerase chain reaction (PCR) to detect P. falciparum parasites and gametocytes.

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The acceptability of intermittent screening and treatment versus intermittent preventive treatment during pregnancy: results from a qualitative study in Northern Ghana

November 26, 2014 - 15:02 -- Open Access
Author(s): 
Christopher Pell, Arantza Meñaca, Samuel Chatio, Abraham Hodgson, Harry Tagbor, Robert Pool
Reference: 
Malaria Journal 2014, 13:432 (18 November 2014)

Ten in-depth interviews were carried out with clinical trial staff. Observations were also made at the health facilities where the clinical trial took place.

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Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009–2013)

November 25, 2014 - 17:12 -- Open Access
Author(s): 
Abu N. Mohon, Mohammad S. Alam, Abebe G. Bayih, Asongna Folefoc, Dea Shahinas, Rashidul Haque, Dylan R Pillai
Reference: 
Malaria Journal 2014, 13:431 (18 November 2014)

This group undertook to evaluate if mutations seen in Cambodia have emerged in Bangladesh where ACT use is now standard for a decade.

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Therapeutic efficacy of artemether-lumefantrine on treatment of uncomplicated Plasmodium falciparum mono-infection in an area of high malaria transmission in Zambia

November 25, 2014 - 17:06 -- Open Access
Author(s): 
Busiku Hamainza, Freddie Masaninga, Hawela Moonga, Mulenga Mwenda, Pascalina Chanda-kapata, Victor Chalwe, Emmanuel Chanda, Mulakwa Kamuliwo, Olusegun Ayorinde Babaniyi
Reference: 
Malaria Journal 2014, 13:430 (17 November 2014)

This study assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL)(Coartem(R)) for the treatment of uncomplicated Plasmodium falciparum malaria in two sentinel high malaria transmission districts in the Eastern Province of Zambia in persons aged six months and above, excluding women aged 12 to 18 years.

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High-resolution melting analysis reveals low Plasmodium parasitaemia infections among microscopically negative febrile patients in western Kenya

November 25, 2014 - 17:02 -- Open Access
Author(s): 
Purity N Kipanga, David Omondi, Paul O Mireji, Patrick Sawa, Daniel K Masiga, Jandouwe Villinger
Reference: 
Malaria Journal 2014, 13:429 (15 November 2014)

This is the first study that employs low-parasitaemia Plasmodium diagnostics to quantify the prescription of anti-malarial drugs to both non-malaria febrile patients and patients with low-parasitaemia Plasmodium infections.

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The effect of intermittent preventive treatment on anti-malarial drug resistance spread in areas with population movement

November 25, 2014 - 16:54 -- Open Access
Author(s): 
Miranda I Teboh-Ewungkem, Jemal Mohammed-Awel, Frederick N Baliraine, Scott M Duke-Sylvester
Reference: 
Malaria Journal 2014, 13:428 (15 November 2014)

A theoretical framework, as presented here, is thus relevant as the role of IPTi on accelerating the spread of drug resistance can be isolated in individual populations and when the populations are interconnected and interact.

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