By the end of the study period, the larval population at the experimental site was six-fold smaller than the concurrent larval population at the control site. The ensuing adult An. sergentii population was also reduced to about 60% at the experimental site, while the adult mosquito population at the control site had increased 2.4 fold over the same time-frame.
This study offers one of the first lncRNA secondary structure analyses in vector insects. Our description of lncRNAs in An. gambiae offers the most comprehensive genome-wide insights to date into lncRNAs in this vector mosquito, and defines a set of potential targets for the development of vector-based interventions that may further curb the human malaria burden in disease-endemic countries.
Plasmodium falciparum invasion of human red blood cells (RBCs) is an intricate process requiring a number of distinct ligand-receptor interactions at the merozoite-erythrocyte interface.
A β-carbonic anhydrase (CA, EC 188.8.131.52) was cloned, purified and characterized from Anopheles gambiae, the mosquito species mainly involved in the transmission of malaria.
During the erythrocytic cycle of Plasmodium falciparum malaria parasites break down host hemoglobin, resulting in the release of free heme (ferriprotoporphyrin IX).
The development of a highly effective malaria vaccine remains a key goal to aid in the control and eventual eradication of this devastating parasitic disease.
Co-treatment of AL with EFV-based ART but not NVP-based ART significantly reduces lumefantrine bioavailability and consequently total exposure.
This paper grew out of a meeting organized in October 2014 in London on ‘Re-imagining malaria’.
Sri Lanka has reached zero indigenous malaria cases in November 2012, two years before its targeted deadline for elimination.
Plasmodium vivax malaria incidence is highly heterogeneous in space and time in the urban study area with important geographical and housing risk factors associated with symptomatic episodes.