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Scientific Articles

NOT Open Access | Ferroquine and its derivatives: New generation of antimalarial agents

August 31, 2015 - 15:44 -- NOT Open Access
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Author(s): 
Waseem A. Wani, Ehtesham Jameel, Umair Baig, Syed Mumtazuddin, Lee Ting Hun
Reference: 
European Journal of Medicinal Chemistry, Volume 101, 28 August 2015, Pages 534–551

Malaria has been teasing human populations from a long time.

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NOT Open Access | Sexual development in Plasmodium parasites: knowing when it's time to commit

August 31, 2015 - 15:40 -- NOT Open Access
Author(s): 
Gabrielle A. Josling & Manuel Llinas
Reference: 
Nature Reviews Microbiology 13, 573–587 (2015)

Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan parasites of the genus Plasmodium.

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A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy

August 31, 2015 - 15:39 -- Open Access
Author(s): 
Harry Tagbor, Matthew Cairns, Brian Greenwood, et al.
Reference: 
PLoS ONE 10(8): e0132247

Despite low levels of resistance to SP in the study areas, ISTp-AL performed as well as IPTp-SP.

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Not Open Access | Screening of potential targets in Plasmodium falciparum using stage-specific metabolic network analysis

August 26, 2015 - 17:17 -- NOT Open Access
Author(s): 
Neel Dholakia, Pinakin Dhandhukia, Nilanjan Roy
Reference: 
dholakianeel@gmail.com

In this study, microarray data were analysed for differential expression and overlapped onto metabolic pathways to identify differentially regulated pathways essential for transition to successive erythrocytic stages. 

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Not Open Access | Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse

August 26, 2015 - 16:58 -- NOT Open Access
Author(s): 
Jessica T. Lin, Nicholas J. Hathaway, Jonathan J. Juliano, et al.
Reference: 
The Journal of Infectious Diseases Volume 212, Issue 6Pp. 999-1008

We applied amplicon deep sequencing to P. vivax isolates from 78 Cambodian volunteers, nearly one-third of whom suffered recurrence at a median of 68 days. Deep sequencing at a highly variable region of the P. vivax merozoite surface protein 1 gene revealed impressive diversity—generating 67 unique haplotypes and detecting on average 3.6 cocirculating parasite clones within individuals, compared to 2.1 clones detected by a combination of 3 microsatellite markers. 

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Patterns of Infection and Patterns of Evolution: How a Malaria Parasite Brought “Monkeys and Man” Closer Together in the 1960s

August 26, 2015 - 16:53 -- Open Access
Author(s): 
Rachel Mason Dentinger
Reference: 
Journal of the History of Biology, August 2015,

This paper follows Coatney’s team of parasitologists and their subjects: from the human to the nonhuman; from the American laboratory to the forests of Malaysia; and between the domains of medical research and natural history. In the course of this research, Coatney and his colleagues inverted Koch’s postulate, by which animal subjects are used to identify and understand human parasites. 

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Determinants of Adherence with Malaria Chemoprophylactic Drugs Used in a Traveler’s Health Clinic

August 26, 2015 - 16:37 -- Open Access
Author(s): 
Ibrahim Shady
Reference: 
Journal of Tropical Medicine, Volume 2015 (2015)

To detect the determinants of travelers’ adherence to malaria chemoprophylaxis. Methods. A prospective comparative study was conducted from January 2012 to July 2013 that included travelers (928 travelers) to malaria endemic countries who visited the THC. 

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Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

August 26, 2015 - 16:21 -- Open Access
Author(s): 
Sim Kheng, Sinoun Muth, Eva Christophe, et al.
Reference: 
BMC Medicine 2015, 13:203

This study was conducted to assess the tolerability of a primaquine regimen in Cambodian severely deficient G6PD variants to ascertain whether a weekly primaquine could be given without testing for G6PDd.

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Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice

August 26, 2015 - 15:59 -- Open Access
Author(s): 
Voravuth Somsak, Sukanya Chachiyo, Ubonwan Jaihan, and Somrudee Nakinchat
Reference: 
Journal of Tropical Medicine, Volume 2015 (2015), Article ID 961205, 5 pages

In this study, we investigated the protective effect of aqueous crude extract of Azadirachta indica (neem) leaves on renal injury induced by Plasmodium berghei ANKA infection in mice. 

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Karyotypic assignment of Sri Lankan Anopheles culicifacies species B and E does not correlate with cytochrome oxidase subunit I and microsatellite genotypes

August 26, 2015 - 07:32 -- Open Access
Author(s): 
Sinnathamby N. Surendran, Nathan Truelove, Devojit K. Sarma, Pavilupillai J. Jude, Ranjan Ramasamy, Kanapathy Gajapathy, Lalanthika B. S. Peiris, S. H. P. Parakrama Karunaratne and Catherine Walton
Reference: 
Parasites & Vectors 2015, 8:327

Detailed analysis with more microsatellite markers and assortative mating experiments are needed to establish the presence of the two genetically distinct populations and relate them to Y-chromosome morphology.

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