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Scientific Articles

Not Open Access | Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice

August 27, 2014 - 14:39 -- NOT Open Access
Author(s): 
Cailin Deal, Alejandro B. Balazs, Diego A. Espinosa, Fidel Zavala, David Baltimore, and Gary Ketner
Reference: 
PNAS August 26, 2014 vol. 111 no. 34 12528-12532

Malaria caused by Plasmodium falciparum kills nearly one million children each year and imposes crippling economic burdens on families and nations worldwide.

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NOT Open Access | Endoperoxide polyketides from a Chinese Plakortis simplex: Further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes

August 27, 2014 - 14:35 -- NOT Open Access
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Author(s): 
Giuseppina Chianese, Marco Persico, Caterina Fattorusso, et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 22, Issue 17, 1 September 2014, Pages 4572–4580

Chemical investigation of the organic extract obtained from the sponge Plakortis simplex collected in the South China Sea afforded five new polyketide endoperoxides (2 and 4–7), along with two known analogues (1 and 3).

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Increasing role of Anopheles funestus and Anopheles arabiensis in malaria transmission in the Kilombero Valley, Tanzania

August 27, 2014 - 14:33 -- Open Access
Author(s): 
Lwetoijera DW, Harris C, Kiware SS, Dongus S, Devine GJ, McCall PJ, Majambere S
Reference: 
Malaria Journal 2014, 13 :331 (24 August 2014)

The results indicate the continuing role of An. arabiensis and the increasing importance of An. funestus in malaria transmission, and pyrethroid resistance development in both species.

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Characterizing, controlling and eliminating residual malaria transmission

August 27, 2014 - 14:18 -- Open Access
Author(s): 
Killeen GF
Reference: 
Malaria Journal 2014, 13 :330 (23 August 2014)

Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) interventions can reduce malaria transmission by targeting mosquitoes when they feed upon sleeping humans and/or rest inside houses, livestock shelters or other man-made structures.

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NOT Open Access | 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

August 27, 2014 - 14:16 -- NOT Open Access
Author(s): 
Néstor M. Carballeira, Angela Gono Bwalya, Deniz Tasdemir, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 17, 1 September 2014, Pages 4151–4157

The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease.

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NOT Open Access | In search of next generation antimalarials

August 27, 2014 - 14:11 -- NOT Open Access
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Author(s): 
Sankar Chatterjee, Keiichi Tanabe, Edward A. Nodiff
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 17, 1 September 2014, Pages 4106–4109

Compounds 7–10 displayed potency without any apparent toxicity

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NOT Open Access | Characterization of the Rel2-regulated transcriptome and proteome of Anopheles stephensi identifies new anti-Plasmodium factors

August 27, 2014 - 14:09 -- NOT Open Access
Author(s): 
Andrew Pike, Alekhya Vadlamani, Simone L. Sandiford, Anthony Gacita, George Dimopoulos
Reference: 
Insect Biochemistry and Molecular Biology Volume 52, September 2014, Pages 82–93

Mosquitoes possess an innate immune system that is capable of limiting infection by a variety of pathogens, including the Plasmodium spp. parasites responsible for human malaria.

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Development and validation of climate and ecosystem-based early malaria epidemic prediction models in East Africa

August 27, 2014 - 14:05 -- Open Access
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Author(s): 
Githeko AK, Ogallo L, Lemnge M, Okia M, Ototo EN
Reference: 
Malaria Journal 2014, 13 :329 (22 August 2014)

The additive and multiplicative models were validated and were shown to be robust and with high climate-based, early epidemic predictive power.

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Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study

August 27, 2014 - 09:40 -- Open Access
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Author(s): 
Ndong IC, van Reenen M, Boakye DA, Mbacham WF, Grobler AF
Reference: 
Malaria Journal 2014, 13 :328 (22 August 2014)

The changes to the treatment guidelines appear to result in a declining trend as was observed between 2006 and 2008.

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In vitro antiplasmodial activity of cepharanthine

August 27, 2014 - 09:38 -- Open Access
Author(s): 
Desgrouas C, Chapus C, Desplans J, Travaille C, Pascual A, Baghdikian B, Ollivier E, Parzy D, Taudon N
Reference: 
Malaria Journal 2014, 13 :327 (22 August 2014)

The blockage at the ring stage by cepharanthine is described for the first time.

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