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Scientific Articles

NOT Open Access | RNase silences Plasmodium antigens

July 21, 2014 - 16:36 -- NOT Open Access
Author(s): 
Christina Tobin Kåhrström
Reference: 
Nature Reviews Microbiology 12, 531, (2014)

Immune evasion by Plasmodium falciparum involves differential expression of var genes, which encode members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family that are expressed on the surface of infected erythrocytes;

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Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria

July 21, 2014 - 14:20 -- Open Access
Author(s): 
Prakash Srinivasan, Emmanuel Ekanem, Ababacar Diouf, Michelle L. Tonkin, Kazutoyo Miura, Martin J. Boulanger, Carole A. Long, David L. Narum, and Louis H. Miller
Reference: 
PNAS July 15, 2014 vol. 111 no. 28 10311-10316

An essential step in the invasion of red blood cells (RBCs) by Plasmodium falciparum (Pf) merozoites is the binding of rhoptry neck protein 2 (RON2) to the hydrophobic groove of apical membrane antigen 1 (AMA1), triggering junction formation between the apical end of the merozoite and the RBC surface to initiate invasion.

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NOT Open Access | Flow Cytometry-Based Analysis of Artemisinin-Resistant Plasmodium falciparum in the Ring-Stage Survival Assay

July 21, 2014 - 14:18 -- NOT Open Access
Author(s): 
Chanaki Amaratunga, Aaron T. Neal, and Rick M. Fairhurst
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4938-4940

The ring-stage survival assay (RSA) is a powerful tool for phenotyping artemisinin-resistant Plasmodium falciparum but requires experienced microscopists to count viable parasites among 10,000 erythrocytes in Giemsa-stained thin blood smears.

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NOT Open Access | Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro

July 21, 2014 - 14:16 -- NOT Open Access
Author(s): 
Chanaki Amaratunga, Benoit Witkowski, Dalin Dek, Vorleak Try, Nimol Khim, Olivo Miotto, Didier Ménard, and Rick M. Fairhurst
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4935-4937

Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life.

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NOT Open Access | Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum

July 21, 2014 - 12:51 -- NOT Open Access
Author(s): 
Nanhua Chen, Alexis N. LaCrue, Franka Teuscher, Norman C. Waters, Michelle L. Gatton, Dennis E. Kyle, and Qin Cheng
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4773-4781

Artemisinin (ART)-based combination therapy (ACT) is used as the first-line treatment of uncomplicated falciparum malaria worldwide.

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NOT Open Access | Radicicol Confers Mid-Schizont Arrest by Inhibiting Mitochondrial Replication in Plasmodium falciparum

July 21, 2014 - 12:49 -- NOT Open Access
Author(s): 
Sureshkumar Chalapareddy, Mrinal Kanti Bhattacharyya, Seema Mishra, and Sunanda Bhattacharyya
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4341-4352

Radicicol, an antifungal antibiotic, was previously identified as a compound having antimalarial activity.

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Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine

July 21, 2014 - 12:47 -- Open Access
Author(s): 
Alice C. Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R. Kamya, Shunmay Yeung, Sarah G. Staedke, Teun Bousema, and Chris Drakeley
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4971-4973

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test.

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NOT Open Access | Population Pharmacokinetics and Clinical Response for Artemether-Lumefantrine in Pregnant and Nonpregnant Women with Uncomplicated Plasmodium falciparum Malaria in Tanzania

July 16, 2014 - 07:57 -- NOT Open Access
Author(s): 
Dominic Mosha, Monia Guidi, Felista Mwingira, Salim Abdulla, Thomas Mercier, Laurent Arthur Decosterd, Chantal Csajka, and Blaise Genton
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4583-4592

Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated malaria in the second and third trimesters of pregnancy.

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NOT Open Access | Treatment of Murine Cerebral Malaria by Artemisone in Combination with Conventional Antimalarial Drugs: Antiplasmodial Effects and Immune Responses

July 16, 2014 - 07:55 -- NOT Open Access
Author(s): 
W. Armand Guiguemde, Nicholas H. Hunt, Jintao Guo, Annael Marciano, Richard K. Haynes, Julie Clark, R. Kiplin Guy, and Jacob Golenser
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4745-4754

The decreasing effectiveness of antimalarial therapy due to drug resistance necessitates constant efforts to develop new drugs.

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NOT Open Access | Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights from Computational Modeling and Clinical Case Reports

July 16, 2014 - 07:53 -- NOT Open Access
Tags: 
Author(s): 
Gilles Cottrell, Lise Musset, Véronique Hubert, Jacques Le Bras, Jérôme Clain, the Atovaquone-Proguanil Treatment Failure Study Group
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4504-4514

The usefulness of atovaquone-proguanil (AP) as an antimalarial treatment is compromised by the emergence of atovaquone resistance during therapy.

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