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Scientific Articles

Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

January 28, 2015 - 16:26 -- Open Access
Author(s): 
Mostafa A. Elfawal, Melissa J. Towler, Nicholas G. Reich, Pamela J. Weathers, Stephen M. Rich
Reference: 
PNAS January 20, 2015 vol. 112 no. 3 821-826

Pharmaceutical monotherapies against human malaria have proven effective, although ephemeral, owing to the inevitable evolution of resistant parasites.

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Not Open Access | Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion

January 28, 2015 - 16:25 -- NOT Open Access
Author(s): 
K. Sony Reddy, Emmanuel Amlabu, Alok K. Pandey, Pallabi Mitra, Virander S. Chauhan, and Deepak Gaur
Reference: 
PNAS January 27, 2015 vol. 112 no. 4 1179-1184

Erythrocyte invasion by Plasmodium falciparum merozoites is a highly intricate process in which Plasmodium falciparum reticulocyte binding-like homologous protein 5 (PfRH5) is an indispensable parasite ligand that binds with its erythrocyte receptor, Basigin.

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NOT Open Access | First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

January 28, 2015 - 16:21 -- NOT Open Access
Author(s): 
Shirin Bruderer, Noémie Hurst, Ruben de Kanter, Tommaso Miraval, Thomas Pfeifer, Yves Donazzolo, and Jasper Dingemanse
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 935-942

Emerging resistance to antimalarial agents raises the need for new drugs.

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Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

January 28, 2015 - 16:20 -- Open Access
Author(s): 
Suresh B. Lakshminarayana, Céline Freymond, Francesca Blasco, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 1200-1210

Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs.

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Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

January 28, 2015 - 16:19 -- Open Access
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Author(s): 
Nicholas A. Malmquist, Sandeep Sundriyal, Artur Scherf, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 950-959

Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites.

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NOT Open Access | Therapeutic Responses of Plasmodium vivax Malaria to Chloroquine and Primaquine Treatment in Northeastern Myanmar

January 28, 2015 - 16:17 -- NOT Open Access
Author(s): 
Lili Yuan, Ying Wang, Liwang Cui, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 1230-1235

Chloroquine-primaquine (CQ-PQ) continues to be the frontline therapy for radical cure of Plasmodium vivax malaria.

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Identification and Deconvolution of Cross-Resistance Signals from Antimalarial Compounds Using Multidrug-Resistant Plasmodium falciparum Strains

January 28, 2015 - 16:16 -- Open Access
Author(s): 
Monika Chugh, Christian Scheurer, Xavier C. Ding, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 1110-1118

Plasmodium falciparum, the most deadly agent of malaria, displays a wide variety of resistance mechanisms in the field.

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Plasmodium alveolins possess distinct but structurally and functionally related multi-repeat domains

January 28, 2015 - 16:15 -- Open Access
Author(s): 
Fatimah S. Al-Khattaf , Annie Z. Tremp & Johannes T. Dessens
Reference: 
Parasitology Research February 2015, Volume 114, Issue 2, pp 631-639

The invasive and motile life stages of malaria parasites (merozoite, ookinete and sporozoite) possess a distinctive cortical structure termed the pellicle.

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NOT Open Access | Laboratory evaluation of Indian medicinal plants as repellents against malaria, dengue, and filariasis vector mosquitoes

January 28, 2015 - 16:14 -- NOT Open Access
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Author(s): 
Marimuthu Govindarajan & Rajamohan Sivakumar
Reference: 
Parasitology Research, February 2015, Volume 114, Issue 2, pp 601-612

Mosquito-borne diseases have an economic impact, including loss in commercial and labor outputs, particularly in countries with tropical and subtropical climates; however, no part of the world is free from vector-borne diseases.

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The case for a rational genome-based vaccine against malaria

January 28, 2015 - 15:23 -- Open Access
Author(s): 
Carla Proietti and Denise L. Doolan
Reference: 
Front. Microbiol., 22 January 2015

 We advocate that development of an optimally efficacious malaria vaccine will need to improve on nature, and that this can be accomplished by rational vaccine design facilitated by mining genomic, proteomic and transcriptomic datasets in the context of relevant biological function.

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