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This study aimed to address this question. Methodology and Findings An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007.
Our results indicates that PvMSP3 is highly immunogenic in naturally exposed populations, where 78% of studied individuals present IgG immune response against the full-length recombinant protein (PVMSP3-FL) and IgG subclass profile was similar to all five recombinant proteins studied with a high predominance of IgG1 and IgG3.
These data help characterize the clinical profile of severe P. vivax malaria in Latin America.