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Open Access | Intermittent Preventive Treatment for Malaria in Papua New Guinean Infants Exposed to Plasmodium falciparum and P. vivax: A Randomized Controlled Trial

Submitted by patrick sampao on March 30, 2012 - 12:34
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Author(s): 
Nicolas Senn, Patricia Rarau, Ivo Mueller, et al.
Reference: 
PLoS Med 9(3): e1001195.
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ivomueller@fastmail.fm

MalariaWorldIn this study, 1,121 Papua New Guinean infants were enrolled into a three-arm placebo-controlled randomized trial and assigned to sulfadoxine-pyrimethamine (SP) (25 mg/kg and 1.25 mg/kg) plus amodiaquine (AQ) (10 mg/kg, 3 d, n = 374), SP plus artesunate (AS) (4 mg/kg, 3 d, n = 374), or placebo (n = 373), given at 3, 6, 9 and 12 mo. Both participants and study teams were blinded to treatment allocation.

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Rapid Diagnostic Test–Based Management of Malaria: An Effectiveness Study in Papua New Guinean Infants With Plasmodium falciparum and Plasmodium vivax Malaria

Submitted by patrick sampao on February 10, 2012 - 14:34
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Author(s): 
Nicolas Senn, Patricia Rarau, Doris Manong, Mary Salib, Peter Siba, Leanne J. Robinson, John Reeder, Stephen Rogerson, Ivo Mueller and Blaise Genton
Reference: 
Clinical Infectious Diseases, Volume 54, Issue 5 Pp. 644-651.
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Contact email: 
nicolas.senn@gmail.com

MalariaWorldWe evaluated the safety of withholding antimalarial drugs from young Papua New Guinean children with negative RDT results in areas with high levels of both Plasmodium falciparum and P. vivax infections.

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Minimal Association of Common Red Blood Cell Polymorphisms with Plasmodium falciparum Infection and Uncomplicated Malaria in Papua New Guinean School Children

Submitted by patrick sampao on October 4, 2010 - 11:57
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Author(s): 
Enmoore L., Livingstone T., et al.
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 828 - 833.
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Contact email: 
enmoorelin@yahoo.com

In a cohort of children 5–14 years of age the effect of +-thalassemia, SAO (SLC4A127), CR1 polymorphisms, and Gerbich negativity (GYPCex3) on risk of P. falciparum infections and uncomplicated illness were evaluated.

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