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Efficacy and Effectiveness of Mefloquine and Artesunate Combination Therapy for Uncomplicated Plasmodium falciparum Malaria in the Peruvian Amazon

Submitted by patrick sampao on September 8, 2011 - 07:53
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Author(s): 
Alexandre Macedo de Oliveira, Jorge Chavez, Gabriel Ponce de Leon, Salomon Durand, Nancy Arrospide, Jacquelin Roberts, Cesar Cabezas and Wilmer Marquiño
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 3 573-578
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Contact email: 
acq7@cdc.gov

Our study shows that MQ + AS is highly efficacious in the Peruvian Amazon.

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Open Access | Plasmodium falciparum Genetic Diversity Maintained and Amplified Over 5 Years of a Low Transmission Endemic in the Peruvian Amazon

Submitted by patrick sampao on June 14, 2011 - 14:12
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Author(s): 
OraLee H. Branch, Patrick L. Sutton, Carmen Barnes, Juan Carlos Castro, Julie Hussin, Philip Awadalla and Gisely Hijar
Reference: 
Mol Biol Evol (2011) 28 (7): 1973-1986.
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Contact email: 
oralee.branch@nyumc.org

We examined parasite population structure and traced the parasite genetic diversity temporally and spatially. We genotyped infections over 5 years (2003–2007) using 14 microsatellite (MS) markers scattered across ten different chromosomes. Despite low transmission, there was considerable genetic diversity, which we compared with other geographic regions.

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On the validity of self-reports and indirect reports to ascertain malaria prevalence in settings of hypoendemicity

Submitted by patrick sampao on March 2, 2011 - 07:50
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Author(s): 
Mathieu Maheu-Giroux, Martín Casapía, Theresa W. Gyorkos
Reference: 
Social Science & Medicine, Volume 72, Issue 5, March 2011, Pages 635-640
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Contact email: 
theresa.gyorkos@mcgill.ca

The aim of our research was to determine the validity of self-report and indirect report in ascertaining malaria prevalence over six, eighteen and thirty-month time periods. Reports of malaria episodes collected through interviewer-administered questionnaires (193 self-reports, 614 indirect reports) were compared to microscopy-confirmed cases (principally Plasmodium vivax) registered at a government-run health post in the Peruvian Amazon.

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