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Malarial mosquitoes completely controlled in experiments that mimic natural environments

Science Daily - July 29, 2021 - 16:21
Researchers have shown 'gene drive' technology, which spreads a genetic modification blocking female reproduction, works in natural-like settings.

New insights into immune responses to malaria

Science Daily - July 23, 2021 - 14:52
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.

Global warming may limit spread of dengue fever, new research finds

Science Daily - July 22, 2021 - 18:19
Infection with dengue virus makes mosquitoes more sensitive to warmer temperatures, according to new research. The team also found that infection with the bacterium Wolbachia, which has recently been used to control viral infections in mosquitoes, also increases the thermal sensitivity of the insects. The findings suggest that global warming could limit the spread of dengue fever but could also limit the effectiveness of Wolbachia as a biological control agent.

Blocking how the malaria parasite suppresses the immune response

Science Daily - July 21, 2021 - 14:23
The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.

Malaria and dengue predicted to affect billions more people

Science Daily - July 7, 2021 - 22:53
An estimated 8.4 billion people could be at risk from malaria and dengue by the end of the century if emissions keep rising at current levels, according to a new study.

Investigational malaria vaccine gives strong, lasting protection

Science Daily - June 30, 2021 - 15:53
Two U.S. Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedentedly high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites. The vaccine combines live parasites with either of two widely used antimalarial drugs -- an approach termed chemoprophylaxis vaccination. A Phase 2 clinical trial of the vaccine is now underway in Mali, a malaria-endemic country.

Antibodies help identify women protected from placental malaria

Science Daily - June 29, 2021 - 16:08
Six antibody characteristics could help scientists identify which pregnant women are at risk of placental malaria infections.

mRNA vaccine yields full protection against malaria in mice

Science Daily - June 18, 2021 - 13:17
Scientists developed an mRNA vaccine that protects against malaria in animal models. Malaria remains a large public health and economic burden worldwide as well as a danger to deployed Service Members. This vaccine uses mRNA accompanied by a lipid nanoparticle to prompt cells to code for circumsporozoite protein, which then triggers an immune response against malaria. The vaccine achieved high levels of protection in mice, encouraging further development for the novel platform.

'Mosquito smoothie' innovation boosts future malaria vaccine potential

Science Daily - June 17, 2021 - 17:38
A faster method for collecting pure malaria parasites from infected mosquitos could accelerate the development of new, more potent malaria vaccines.

Children with asymptomatic malaria a 'hidden risk' to disease control efforts

Science Daily - June 16, 2021 - 23:15
The role of people infected with malaria without showing symptoms presents a hidden risk to efforts to control the disease after they were found to be responsible for most infections in mosquitoes, according to a new study.

Easy, inexpensive, efficient: Researchers improve efficacy of new malaria drug

Science Daily - June 14, 2021 - 17:11
Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team has now pushed this a bit further. They have developed a very simple method for preparing the active ingredient that makes it easier to administer and store.

Parasites may accumulate in spleens of asymptomatic individuals infected with malaria

Science Daily - June 1, 2021 - 19:20
Malaria, a disease caused mainly by the parasites Plasmodium falciparum and Plasmodium vivax, is associated with over 400,000 deaths each year. Previously, the spleen was assumed to mostly play a role in parasite destruction, as it eliminates malaria parasites after antimalarial treatment. A new study suggests that in chronic P. vivax infections, malaria parasites survive and replicate via a previously undetected lifecycle within the spleen.

New CRISPR tools help contain mosquito disease transmission

Science Daily - May 28, 2021 - 18:48
Scientists have developed a genetics toolkit that helps pave the way to a gene drive designed to stop Culex mosquitoes from spreading disease. Much less studied than other genera, Culex mosquitoes spread devastating afflictions stemming from West Nile virus, Japanese encephalitis virus and the pathogen causing avian malaria.

Climate change makes West Nile virus outbreaks 'plausible' in UK

Science Daily - May 28, 2021 - 16:59
Climate change will make outbreaks of West Nile virus more likely in the UK within the next 20-30 years, a new study has found. A new scientific model shows the risk of the mosquito-borne pathogen spreading to the country will increase as temperatures rise.

Scientists design new drug compound to stop malaria in its tracks

Science Daily - May 12, 2021 - 18:35
Researchers have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

Natural immunity to malaria provides clues to potential therapies

Science Daily - May 3, 2021 - 13:35
Researchers have identified how natural human antibodies can block malaria parasites from entering red blood cells, potentially indicating how new protective therapies could be developed against this globally significant disease. The research provides greater insight into how antibodies block the entry of Plasmodium vivax malaria parasites into young red blood cells called reticulocytes. It builds on an earlier discovery that the P. vivax latches onto the transferrin receptor 1 (TfR1) to enter cells.

Malaria vaccine becomes first to achieve WHO-specified 75 percent efficacy goal

Science Daily - April 23, 2021 - 12:57
Researchers reported findings from a Phase IIb trial of a candidate malaria vaccine, R21/Matrix-M, which demonstrated high-level efficacy of 77 percent over 12 months of follow-up.

Certain gut microbes make mosquitoes more prone to carry malaria parasite

Science Daily - April 20, 2021 - 16:15
Dietary sugars and gut microbes play a key role in promoting malaria parasite infection in mosquitoes. Researchers have uncovered evidence that mosquitoes fed a sugar diet show an increased abundance of the bacterial species Asaia bogorensis, which enhances parasite infection by raising the gut pH level.

Simple genetic modification aims to stop mosquitoes spreading malaria

Science Daily - April 13, 2021 - 15:06
Altering a mosquito's gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria.

Mysteries of malaria infections deepen after human trial study

Science Daily - March 30, 2021 - 16:12
Scientists have discovered that tracking malaria as it develops in humans is a powerful way to detect how the malaria parasite causes a range of infection outcomes in its host. The study, found some remarkable differences in the way individuals respond to malaria and raises fresh questions in the quest to understand and defeat the deadly disease.


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