Rhomboid proteases are clinically relevant membrane proteins that play a key role in various diseases. Using solid-state NMR spectroscopy, researchers have now been able to watch rhomboid proteases in a native lipid environment at work. The obtained dynamic images will be useful for the development of new medication for diseases such as Parkinson's and malaria.
Immune cells can be the body's defenders and foes at the same time.
Since its invention during the Second World War for soldiers stationed in countries where malaria transmission rates were high, researchers have worked to pinpoint precisely how DEET actually affects mosquitoes.
Despite humanity's best efforts to eradicate malaria, the disease struck more than 200 million people in 2017, according to the World Health Organization. Worse yet, the parasite that causes malaria is developing resistance to many antimalarial drugs, including the mainstay, chloroquine. Researchers are actively searching for new treatments, and now, a group have found that acaí berry extracts can reduce parasites in the blood and prolong the survival of infected mice.
Low-income urban neighborhoods not only have more mosquitoes, but they are larger-bodied, indicating that they could be more efficient at transmitting diseases. So reports investigating how socioeconomics influences mosquito-borne disease risk in Baltimore, Maryland.
A computational analysis has identified key regions in the United States where model-based predictions of mosquito species distribution could be improved.
For the first time ever, a professor has observed a crystallized iron product called hemozoin being made in mammals, with widespread implications for future research and treatment of blood disorders. Findings could be used to treat sickle cell disease and malaria patients, while opening up diverse research avenues across immunology, parasitology, neuroscience, microbiology, and even urology.
Nonhuman primates with clinically undetectable Plasmodium relapse infections still harbor parasitic gametocytes that may be infectious to mosquitoes, according to a new study.
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.
A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher's inspired hunch when the psoriasis drug discovery program came to a dead end. The candidate drug offers considerable potential for combating this infectious disease.
Mosquitoes are more likely to acquire the dengue virus when they feed on blood with low levels of iron, researchers report. Supplementing people's diets with iron in places where both iron deficiency anemia and dengue fever are a problem could potentially limit transmission of the disease, but there are risks.
The frigid waters of the Antarctic may yield a treatment for a deadly disease that affects populations in some of the hottest places on earth. Current medications for that scourge -- malaria -- are becoming less effective as drug resistance spreads. But researchers report that a peptide they isolated from an Antarctic sponge shows promise as a lead for new therapies.
Scientists have identified the regional character to Plasmodium falciparum across Africa. Malaria, infecting 219 million individuals in 2017, remains a threat to public health and regional stability. Human movement and the introduction of antimalarial drugs were drivers of this genetic diversity. Gene flow between sub-populations could spread resistance from one sub-population to the rest of the continent.
Researchers are exploring the relationship between microbial natural products and the gene clusters that enable their production. By learning to recognize what genes lead to what types of products, they hope to use genome sequencing to speed discovery of new natural products that may have key therapeutic properties.
Removing used needles does not reduce the spread of Hepatitis C virus -- instead, changing the ratio of infected to uninfected needles is critical, study finds.
Increased p53, the well-known tumor-suppressor protein, can predict whether malaria-infected children will develop fever or other symptoms, suggests a new study. The authors say the findings could lead to new strategies for dampening the harmful inflammatory responses associated with some infections and identifying individuals who might be at risk for such responses.
Researchers have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.
A new study shows that graphene sheets can block the signals mosquitoes use to identify a blood meal, potentially enabling a new chemical-free approach to mosquito bite prevention.
Targeting the mosquito population within a defined area is the primary way scientists and public health officials mitigate the spread of diseases caused by viruses like Zika, dengue fever, and West Nile. But researchers have discovered that evaluating how humans commute to and from an affected area, as well as their living habits, is key for successful mitigation planning.
Over the last 40 years, the Asian tiger mosquito, Aedes albopictus, has invaded every continent thanks to the transportation of its eggs via human trade and transportation. Researchers have now used the genomes of the mosquitoes to track the history of the invasion and expansion of the species through Albania, Italy, and Greece.