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Science Daily

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Malaria research. Read the latest medical research on malaria, including new control methods and malaria treatments.
Updated: 1 hour 42 min ago

Genetic variation not an obstacle to gene drive strategy to control mosquitoes

April 16, 2020 - 19:18
New research from entomologists clears a potential obstacle to using CRISPR-Cas9 'gene drive' technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.

Low-cost imaging system poised to provide automatic mosquito tracking

April 15, 2020 - 21:14
Mosquito-transmitted diseases such as malaria, dengue and yellow fever are responsible for hundreds of thousands of deaths every year. A new low-cost imaging system could make it easier to track mosquito species that carry disease, enabling a more timely and targeted response.

Deadliest malaria strain protects itself from the immune system

April 13, 2020 - 17:28
The parasite causing the most severe form of human malaria uses proteins to make red blood cells sticky, making it harder for the immune system to destroy it and leading to potentially fatal blood clots. New research has identified how the parasite may control this process.

Stuttering DNA orchestrates the start of the mosquito's life

April 9, 2020 - 14:03
There are large parts of the DNA that are not used for making proteins. This is called 'junk DNA', because its function remained unclear for a long time. However, a certain type of junk DNA that is found in mosquitoes and which repeats itself dozens of times, known as 'satellite DNA', has now been shown to play an essential role in the early development of mosquito embryos.

Experimental anti-malarial drug shows promise in first clinical trial

April 8, 2020 - 16:55
Malaria is a leading killer of children worldwide, and new drugs are needed. New research reports encouraging early clinical results with a new compound.

Is your coffee contributing to malaria risk?

March 9, 2020 - 13:30
Researchers estimate 20% of the malaria risk in deforestation hot spots is driven by the international trade of exports including: coffee, timber, soybean, cocoa, wood products, palm oil, tobacco, beef and cotton. The results of the study can be used for more demand-side approaches to mitigating malaria incidence by focusing on regulating malaria-impacted global supply chains.

Novel compound sparks new malaria treatment hope

March 4, 2020 - 19:15
A novel class of antimalarial compounds that can effectively kill malaria parasites has been developed. In preclinical testing, the compounds were effective against different species of malaria parasites, including the deadly Plasmodium falciparum, and at multiple stages of the parasite lifecycle. The compounds could overcome existing issues of parasite drug resistance. The researchers hope that drugs based on these early compounds will soon enter phase 1 clinical trials.

How malaria detects and shields itself from approaching immune cells

February 18, 2020 - 17:43
Malaria parasites can sense a molecule produced by approaching immune cells and then use it to protect themselves from destruction, according to new findings.

Eco-friendly way to stop mosquitoes

February 13, 2020 - 14:07
An innovative -- and inexpensive -- technique targets mosquito larvae where they live.

How the malaria parasite grows and multiplies

February 11, 2020 - 17:15
Scientists have made a major breakthrough in understanding how the parasite that causes malaria is able to multiply at such an alarming rate, which could be a vital clue in discovering how it has evolved, and how it can be stopped. For the first time, scientists have shown how certain molecules play an essential role in the rapid reproduction of parasite cells, which cause this deadly disease.

Discovery paves path forward in the fight against the deadliest form of malaria

February 8, 2020 - 14:43
Scientists have identified a key molecule involved in the development of cerebral malaria, a deadly form of the tropical disease. The study identifies a potential drug target and way forward toward alleviating this condition for which few targeted treatments are available.

A roadblock for disease-causing parasites

February 3, 2020 - 20:12
Thread-like parasitic worms cause millions of cases of canine heartworm each year, and more than 100 million cases of lymphatic filariasis, also known as elephantiasis, in humans. New research shows that ramping up the immune response of mosquitoes blocked their ability to transmit these harmful parasites.

Scientists discover how malaria parasites import sugar

January 29, 2020 - 18:15
Researchers have established how sugar is taken up by the malaria parasite, a discovery with the potential to improve the development of antimalarial drugs.

TP53 gene variant in people of African descent linked to iron overload, may improve malaria response

January 24, 2020 - 12:39
A rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial infections, along with markers of iron overload in African Americans. Macrophage iron accumulation disrupts their function, resulting in more severe bacterial infections.

Engineered capillaries model traffic in tiny blood vessels

January 23, 2020 - 20:25
3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.

A Zika vaccine could save suffering and costs

January 23, 2020 - 18:41
A new study found that routinely giving the Zika vaccine to women of childbearing age could save money if the risk of Zika is around that of other mosquito-borne diseases like dengue and chikungunya.

Mosquitoes are drawn to flowers as much as people -- and now scientists know why

January 22, 2020 - 13:05
Despite their reputation as blood-suckers, mosquitoes actually spent most of their time drinking nectar from flowers. Scientists have identified the chemical cues in flowers that stimulate mosquitoes' sense of smell and draw them in. Their findings show how cues from flowers can stimulate the mosquito brain as much as a warm-blooded host -- information that could help develop less toxic repellents and better traps.

Molecular understanding of drug interactions suggests pathway to better malaria treatments

January 15, 2020 - 21:40
Researchers have for the first time demonstrated what happens at the molecular level when two compounds known to inhibit crystal growth were combined, yielding new insights into malaria treatments and, more broadly, improving the process of drug development.

New study reveals the origin of complex malaria infections

January 8, 2020 - 21:03
New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease.

A new breakthrough in developing effective antimalarial drugs

December 31, 2019 - 16:18
Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular DNA methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparum parasites.